TMF Attenuates Cognitive Impairment and Neuroinflammation by Inhibiting the MAPK/NF-κB Pathway in Alzheimer’s Disease: A Multi-Omics Analysis

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(2), P. 74 - 74

Published: Feb. 7, 2025

The rising prevalence of Alzheimer's disease (AD) underscores the urgent need for novel therapeutic agents derived from natural sources. Among flavonoids, 3',4',5,7-tetramethoxyflavone (TMF), a structural analog luteolin, has gained attention its favorable pharmacokinetics and potential neuroprotective properties. Despite significant effects TMF, efficacy mechanism action in AD remain unclear. This study explored TMF's pharmacological models, highlighting ability to improve memory cognitive deficits APP/PS1 mice. TMF reduced Aβ plaques, NFTs formation, glial activation while suppressing neuroinflammation through MAPK/NF-κB pathway. Further analysis LPS-induced BV2 cells revealed reduce microglial activation. These findings highlight anti-neuroinflammatory activity suggesting as treatment AD.

Language: Английский

Integrating network pharmacology and multi-omics to explore the potentiating effect and mechanism of Shenlingcao oral liquid on cisplatin chemotherapy in Lewis lung cancer mice

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119843 - 119843

Published: April 1, 2025

Language: Английский