Mechanical properties of stenosed coronary arterial walls with slip velocity

Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(2)

Published: Feb. 1, 2025

In the present manuscript, a detailed exploration of non-Newtonian blood flow along an elastic, stenosed branched coronary artery is undertaken. The study involves coupling laminar model with solid mechanics to achieve fluid–structure interaction through arbitrary Lagrangian–Eulerian approach. characteristics fluid flow, including velocity, pressure, and wall shear stress are examined in relation elastic properties arterial wall. changes several biomechanical parameters, such as principal strain, deformation gradient, Cauchy–Green tensor, Von Mises intima layer, highlight areas vulnerable endothelial dysfunction. upper branch bifurcation observed carry only around 10% total resulting formation recirculation zones at junction where oscillatory elevated. Flow separation noticed point on opposite stream experiencing increased pressure 1.79% that neighborhood. displacement profiles indicate 37.5% rise lower decrease throat stenosis decreasing profile downstream. peak reached inlet, outlet branches experiences relatively low values. results suggest pre-stenotic region upstream more susceptible undergoing dysfunction across walls confining higher probability.

Language: Английский

Neuromodulation of Cerebral Blood Flow: A Physiological Mechanism and Methodological Review of Neurovascular Coupling

Bioengineering, Journal Year: 2025, Volume and Issue: 12(5), P. 442 - 442

Published: April 23, 2025

Neurovascular coupling (NVC) refers to the dynamic regulation of cerebral blood flow via neuronal activity, a mechanism crucial for maintaining normal brain function. This review elucidates intricate physiological mechanisms underlying NVC, emphasizing coordinated roles neurons, glial cells, and vascular cells in mediating activity-induced changes flow. We examine how NVC is impaired neurological disorders such as Alzheimer’s disease stroke, where dysfunction this contributes neurodegeneration deficits. A broad range techniques assessing discussed—encompassing established modalities like transcranial Doppler, near-infrared spectroscopy, functional magnetic resonance imaging (fMRI), well emerging technologies ultrasound miniaturized endoscopy that enable high-resolution monitoring deep regions. also highlight computational modeling approaches simulating dynamics identify novel biomarkers with potential utility early diagnosis. Finally, translational applications—including neuromodulation targeted pharmacological interventions—are explored means restore neurovascular These advancements underscore clinical significance research, paving way improved diagnostic tools therapeutic strategies disorders.

Language: Английский

FSI Modeling and Simulation of Blood Viscosity Impacts on Cavitation in Mechanical Heart Valves

International Journal of Thermofluids, Journal Year: 2024, Volume and Issue: unknown, P. 100962 - 100962

Published: Nov. 1, 2024

Language: Английский