Network toxicology and molecular docking techniques to explore the mechanism of bisphenol A on obesity DOI

Yang Lingjuan,

Yü Huang, Lei Zhang

et al.

International Journal of Environmental Health Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: April 19, 2025

The study investigates how bisphenol A (BPA) exposure may lead to obesity (OB) by identifying molecular mechanisms and suggests a new research approach for examining the health effects of chemical toxins. Researchers identified 237 potential targets associated with BPA OB using CTD, STITCH, DrugBank, GeneCards, OMIM databases. Analysis STRING Cytoscape revealed 10 key targets, including INS, IL-6, AKT1, PPARG. Enrichment analysis via DAVID database indicated that these are primarily involved in PI3K-Akt Insulin signaling pathways. These findings indicate contribute occurrence development influencing apoptosis, proliferation, inflammatory signaling, insulin resistance. Molecular docking showed strong binding PPARG, dynamics simulations revealing stable complex This offers insights into BPA's role supports efforts prevent treat diseases linked BPA-containing plastic products certain BPA-inundated environments.

Language: Английский

Evidence of the occurrence, detection, and ecotoxicity studies of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in aqueous environments DOI
Elizabeth Oyinkansola Omotola, Chinemerem Ruth Ohoro, James F. Amaku

et al.

Journal of Environmental Health Science and Engineering, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 25, 2025

Language: Английский

Citations

0
Network toxicology and molecular docking techniques to explore the mechanism of bisphenol A on obesity DOI

Yang Lingjuan,

Yü Huang, Lei Zhang

et al.

International Journal of Environmental Health Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: April 19, 2025

The study investigates how bisphenol A (BPA) exposure may lead to obesity (OB) by identifying molecular mechanisms and suggests a new research approach for examining the health effects of chemical toxins. Researchers identified 237 potential targets associated with BPA OB using CTD, STITCH, DrugBank, GeneCards, OMIM databases. Analysis STRING Cytoscape revealed 10 key targets, including INS, IL-6, AKT1, PPARG. Enrichment analysis via DAVID database indicated that these are primarily involved in PI3K-Akt Insulin signaling pathways. These findings indicate contribute occurrence development influencing apoptosis, proliferation, inflammatory signaling, insulin resistance. Molecular docking showed strong binding PPARG, dynamics simulations revealing stable complex This offers insights into BPA's role supports efforts prevent treat diseases linked BPA-containing plastic products certain BPA-inundated environments.

Language: Английский

Citations

0