Green Innovation and Synthesis of Honeybee Products-Mediated Nanoparticles: Potential Approaches and Wide Applications

Bioengineering, Journal Year: 2024, Volume and Issue: 11(8), P. 829 - 829

Published: Aug. 14, 2024

Bee products, abundant in bioactive ingredients, have been utilized both traditional and contemporary medicine. Their antioxidant, antimicrobial, anti-inflammatory properties make them valuable for food, preservation, cosmetics applications. Honeybees are a vast reservoir of potentially beneficial products such as honey, bee pollen, bread, beeswax, venom, royal jelly. These rich metabolites vital to human health, including proteins, amino acids, peptides, enzymes, sugars, vitamins, polyphenols, flavonoids, minerals. The advancement nanotechnology has led continuous search new natural sources that can facilitate the easy, low-cost, eco-friendly synthesis nanomaterials. Nanoparticles (NPs) actively synthesized using honeybee which serve dual purposes preventive interceptive treatment strategies due their richness essential metabolites. This review aims highlight potential role this line applications catalysts food preservatives point out anticancer, antibacterial, antifungal, antioxidant underlying impacts. research used several online databases, namely Google Scholar, Science Direct, Sci Finder. overall findings suggest these bee-derived substances exhibit remarkable properties, making promising candidates economical production NPs.

Language: Английский

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Royal Jelly: A Novel Biotemplate for the Green Synthesis of Antibacterial Metal Nanoparticles

Published: Jan. 1, 2025

The application of green synthesis in nanotechnology is rapidly expanding as a safe and eco-friendly alternative to conventional methods. This study explored the potential royal jelly bio-reducing agent for synthesizing metal nanoparticles evaluated their antibacterial activity. Royal exhibited strong antioxidant activity, demonstrated by ABTS (2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonate)) DPPH (2,2-diphenyl-1-picrylhydrazyl) assays, comparable that Trolox. However, it showed weak effects against both Gram-positive Gram-negative bacteria. Using jelly, silver, iron, copper, zinc were synthesized, confirmed Fourier Transform Infrared Spectrometer (FTIR), ultraviolet-visible (UV-Vis), fluorescence spectroscopy, morphological analyses. significant disrupting bacterial cell walls killing bacteria, shown inhibition zone minimum inhibitory concentrations (MIC), bactericidal (MBC), scanning electron microscope (SEM) imaging. research highlights jelly's dual role reducing nanoparticle its applications.

Language: Английский

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Synergistic Artemisia monosperma with royal jelly: antibacterial, antioxidant, antibiofilm, and anti-Alzheimer assay

AMB Express, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 13, 2025

Abstract This investigation aimed to examine the synergistic effects of fresh royal jelly and local wild Artemisia monosperma leaf extract as antibacterial, antioxidant, antibiofilm, anti-Alzheimer activity. Gas chromatography-mass spectrometry (GC–MS) identified 16 compounds in , including tricosadiynoic acid, hexadecenoic octadecenoic acid. In contrast, contained 13 compounds, dodecanoic octadecynoic heptatriacotanol, their derivatives. The exhibited significant antioxidant activity DPPH assay, with IC 50 value 5.48 ± 0.002 µg/mL. Fresh an 14.56 0.004 Both substances antibacterial comparison gentamycin. Synergistic combination (1:1) effectively suppressed growth multidrug-resistant bacterial species, Bacillus subtilis (ATCC 6633), Enterococcus faecalis 10541), Staphylococcus aureus 6538), Klebsiella pneumoniae 13883), Salmonella typhi 6539), Pseudomonas aeruginosa 90274), decreased biofilm Additionally, vitro inhibition (IC ) Butyrylcholinesterase enzyme (BChE) for plant extract, were 4.35 µg/mL, 4.9 3.55 respectively while rivastigmine (positive control) was 3.9 silico analysis reported that bioactive demonstrated high binding affinities, between − 6.6 10.3 kcal/mol, against human acetylcholinesterase protein, beside ADMET gastrointestinal absorption potential inhibitory on CYP1A2 CYP2C9 enzymes. Our study indicated effect a promising activities.

Language: Английский

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Potential Role of Intravenous Royal Jelly in Reducing Post-hepatectomy Liver Dysfunction: A Randomized Controlled Animal StudY

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 296 - 296

Published: March 14, 2025

Background Posthepatectomy liver dysfunction can lead to fatal outcomes, making it a highly undesirable complication. Numerous studies have attempted mitigate after hepatectomy. However, in the context of hepatectomy, Royal Jelly, previously known for its various benefits health, has not been studied. Methods In this study, thirty-two male Wistar rats were randomly divided into two groups. Just before undergoing 80% 16 received intravenous Jelly (RJ group), while remaining administered phosphate-buffered saline blinded manner (PBS group). Four died scheduled time specimen collection, leaving 28 analysis. Forty-eight hours function (bilirubin and prothrombin time) was evaluated all rats. Additionally, hepatocyte proliferation examined using Ki67 marker, which obtained from specimens. The difference bilirubin levels between groups tested Mann-Whitney U test. Ki-67 percentage analyzed t-test. Results RJ group exhibited lower median total level compared PBS (p<0.001). than that (p<0.05). also These findings suggest demonstrated better other group. Conclusions Administer hepatectomy helps protect function. This study indicates potential further research on as possible alternative reducing following surgery or medical conditions.

Language: Английский

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Effects of Different Drying Processes on Bioactive Components, Volatile Compounds, and In Vitro Inhibition of Starch Digestion in Mulberry Leaf Extracts

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 998 - 998

Published: March 14, 2025

The significant demand for medicinal plants with special efficacy has prompted us to adopt appropriate processing methods enhance the nutritional quality and flavor of raw materials. This study evaluated impacts freeze-drying (FD), hot-air drying (HAD), spray (SD) on bioactive compounds, characteristics, inhibition starch digestion in mulberry leaf ethanol extract (MLE). Results indicated that FDMLE exhibited highest total alkaloids content (TAC: 0.14 ± 0.02 mg/g) flavonoid (TFC: 19.32 0.58 mg/g), along inhibitory effects hydrolysis at 180 min (starch rate <50%). microstructure HADMLE was closest powder (ML), but SD better preserved color ML (ΔE = 1.55 0.04). Combined electronic nose gas chromatography-ion mobility spectrometry (GC-IMS) found HAD facilitated conversion precursors into Ethyl formate, rose oxide, (Z)-3-hexenol (M). SDMLE contained higher levels pentanal, (E)-2-hexenal (D), (E)-2-pentanone, 3-Methyl-2-butenal ethyl butyrate, 1-penten-3-one (D). diversity novel volatile compounds (VOCs), 18 newly identified species. In conclusion, FD is a potential method effectively reduce degradation MLE during process.

Language: Английский

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