Golden Tomato Juice Enhances Hepatic PPAR-α Expression, Mitigates Metabolic Dysfunctions and Influences Redox Balance in a High-Fat-Diet Rat Model DOI Creative Commons
Danila Di Majo,

Nicolò Ricciardi,

Alessandra Moncada

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1324 - 1324

Published: Oct. 30, 2024

Golden tomato (GT), harvested at the veraison stage, has gained attention due to its rich content of bioactive compounds and potential health benefits. Previous studies have highlighted GT's antioxidant properties positive effects on metabolic syndrome (MetS), a condition characterized by obesity, dyslipidemia, oxidative stress. This study investigates for first time derivative from GT, i.e., juice (GTJ), which could be candidate development as functional food. We GT juice, identifying 9-oxo-10(E),12(E)-octadecadienoic (9-oxo-10(E),12(E)-ODA) fatty acid, known peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, using High-Performance Liquid Chromatography (HPLC)-mass spectrometry. Then, high-fat-diet (HFD) rat model, we assessed impact daily supplementation in addressing MetS. outlined that GTJ improved body weight leptin-mediated food intake. Moreover, it ameliorated glucose tolerance, lipid profile, systemic redox homeostasis, hepatic stress, steatosis HFD rats. Furthermore, enhances transcription PPAR-α, thus putatively promoting acid oxidation metabolism. These findings suggest mitigates lipidic accumulation halters species level through PPAR-α activation. Our underscores protective against MetS, highlighting future nutraceutical improving dysmetabolism associated alterations.

Language: Английский

Forecasting migraine attacks by managing daily lifestyle: a systematic review as a basis to develop predictive algorithms DOI Creative Commons

Umberto Quartetti,

Filippo Brighina, Giuditta Gambino

et al.

PAIN Reports, Journal Year: 2025, Volume and Issue: 10(2), P. e1247 - e1247

Published: Feb. 5, 2025

Abstract Recent studies attempting to develop forecasting models for new migraine attack onsets, overviewing triggers and protectors, are encouraging but necessitate further improvements produce with high predictive accuracy. This updated review of available data holds the potential enhance precision predicting a attack. study aims evaluate how lifestyle factors affect frequency in adults episodic migraine, contribute development an effective model. A comprehensive search databases, including PubMed, ScienceDirect, Google Scholar, Scopus, was conducted considering published from 2018 December 2023, following PRISMA guidelines. Critical evaluation using Joanna Briggs Institute's appraisal tools. The modifications examined this included dietary habits, physical activity, sleep, stress management. Of 36 analysed, which predominantly exhibited low moderate bias, 18 investigated 7 explored 11 assessed management, 5 sleep patterns. evidence these advocates implementation Furthermore, outcomes carry valuable implications standpoint models. most consistent results were observed relation specific diets, supplements, activity. Although trends noted management research is required elucidate their influence on integration into registered PROSPERO (ID CRD42024511300).

Language: Английский

Citations

0
The remarkable impact of Opuntia Ficus Indica fruit administration on metabolic syndrome: Correlations between cognitive functions, oxidative stress and lipid dysmetabolism in the high-fat, diet-fed rat model DOI Creative Commons
Danila Di Majo,

Nicolò Ricciardi,

Valentina Di Liberto

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117028 - 117028

Published: July 2, 2024

A wealth of evidence underscores the bioactive properties nutraceuticals and functional foods in addressing oxyinflammatory-based diseases with implications at both peripheral central levels. Opuntia ficus-indica (OFI) is well-documented for its health-promoting attributes, though fruit (OFIF) remains relatively understudied. Not only poses Metabolic Syndrome (MetS) cardiometabolic risks but also contributes significantly to cognitive impairment, especially crucial brain areas such as hippocampus hypothalamus.

Language: Английский

Citations

3
Protective effects of lemon nanovesicles: evidence of the Nrf2/HO-1 pathway contribution from in vitro hepatocytes and in vivo high-fat diet-fed rats DOI Open Access
Roberta Gasparro, Giuditta Gambino,

Giulia Duca

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117532 - 117532

Published: Oct. 8, 2024

Language: Английский

Citations

1
96th National Congress of the Italian Society for Experimental Biology | L’Aquila, Italy, 25-28 April 2024 DOI Creative Commons

The Editors

Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale, Journal Year: 2024, Volume and Issue: 97(s1)

Published: April 12, 2024

96th National Congress of the Italian Society for Experimental Biology | L’Aquila, Italy, 25-28 April 2024

Language: Английский

Citations

0
Golden Tomato Juice Enhances Hepatic PPAR-α Expression, Mitigates Metabolic Dysfunctions and Influences Redox Balance in a High-Fat-Diet Rat Model DOI Creative Commons
Danila Di Majo,

Nicolò Ricciardi,

Alessandra Moncada

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1324 - 1324

Published: Oct. 30, 2024

Golden tomato (GT), harvested at the veraison stage, has gained attention due to its rich content of bioactive compounds and potential health benefits. Previous studies have highlighted GT's antioxidant properties positive effects on metabolic syndrome (MetS), a condition characterized by obesity, dyslipidemia, oxidative stress. This study investigates for first time derivative from GT, i.e., juice (GTJ), which could be candidate development as functional food. We GT juice, identifying 9-oxo-10(E),12(E)-octadecadienoic (9-oxo-10(E),12(E)-ODA) fatty acid, known peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, using High-Performance Liquid Chromatography (HPLC)-mass spectrometry. Then, high-fat-diet (HFD) rat model, we assessed impact daily supplementation in addressing MetS. outlined that GTJ improved body weight leptin-mediated food intake. Moreover, it ameliorated glucose tolerance, lipid profile, systemic redox homeostasis, hepatic stress, steatosis HFD rats. Furthermore, enhances transcription PPAR-α, thus putatively promoting acid oxidation metabolism. These findings suggest mitigates lipidic accumulation halters species level through PPAR-α activation. Our underscores protective against MetS, highlighting future nutraceutical improving dysmetabolism associated alterations.

Language: Английский

Citations

0