Detecting N-Phenyl-2-Naphthylamine, L-Arabinose, D-Mannose, L-Phenylalanine, L-Methionine, and D-Trehalose via Photocurrent Measurement DOI Creative Commons
Feng Li, Ruoxi Yang, Jian Xu

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 808 - 808

Published: Dec. 9, 2024

The concentration of small molecules reflects the normality physiological processes in human body, making development simple and efficient detection equipment essential. In this work, inspired by a facile strategy point-of-care detection, two devices were fabricated to detect via photocurrent measurement. A linear response against was found. first device, metal ions introduced into gel substrates made xanthan gum enhance response. N-phenyl-2-naphthylamine measured when iron or manganese used. L-Phenylalanine modified samarium, iron, cerium, ytterbium ions. L-(+)-Arabinose detected gels holmium D-(+)-Mannose ytterbium, manganese, chromium, sodium L-Methionine zinc, chromium second device based on paper sheet. sugar-like molecule synthesized, which then used modify paper. possible since showed trend D-Trehalose. fit conducted derive sensitivity, whose value found be 5542.4. This work offers novel, simple, environmentally sustainable platform that is potentially useful remote areas lacking medical devices.

Language: Английский

Marine heatwaves imperil emblematic reef fishes by altering the energetic landscape of coral reefs DOI Open Access
Robert F. Semmler, Gabrielle Martineau, Nina M. D. Schiettekatte

et al.

Journal of Animal Ecology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Marine heatwaves are increasingly common due to human-induced climate change. Under prolonged thermal stress on coral reefs, corals can undergo bleaching, leading mass mortality and large-scale changes in benthic community composition. While has clear, negative impacts the body condition populations of coral-dependent fish species, mechanisms that drive these remain poorly resolved. Specifically, little is known about effects bleaching (1) nutritional quality corals, (2) nutrient acquisition coral-feeding butterflyfishes (3) dietary selectivity potential supplementary consumption non-coral prey. Here, we evaluate response obligate a event French Polynesia, which resulted high 50% decline corallivore density. We examine butterflyfish composition over two decades, including 2019 multiple prior disturbances. couple data with surveys feeding selectivity, high-resolution molecular assays gut contents before, during after event. Contrary previous studies, corallivores did not strongly alter their preferences for different genera bleaching. They increase non-corals mortality, hard continued dominate diets (>90%). Instead, targeted partially bleached were likely releasing nutrient-rich mucus, they avoided fully dead nutrient-depleted. Moreover, exhibit reduced nitrogen assimilation, indicating may adversely impact acquisition. Coupled increasing frequency recurrent events, severe, long-term jeopardize persistence fishes future.

Language: Английский

Citations

0
Preparation and characterization of a high-surface-activity dust suppressant modified with Epigallocatechin gallate and L-Arabinose DOI
Xiao-Han Wang, Bingyou Jiang,

Shulei Shi

et al.

Construction and Building Materials, Journal Year: 2025, Volume and Issue: 470, P. 140501 - 140501

Published: Feb. 27, 2025

Language: Английский

Citations

0
Combining Metabolomics and Machine Learning to Identify Diagnostic and Prognostic Biomarkers in Patients with Non-Small Cell Lung Cancer Pre- and Post-Radiation Therapy DOI Creative Commons
M. Murcia, Marta Canela-Capdevila,

Raquel García-Pablo

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 898 - 898

Published: July 24, 2024

Lung cancer is the leading cause of cancer-related deaths globally, with non-small cell lung (NSCLC) accounting for over 85% cases and poor prognosis in advanced stages. This study explored shifts circulating metabolite levels NSCLC patients versus healthy controls examined effects conventionally fractionated radiation therapy (CFRT) stereotactic body (SBRT). We enrolled 91 (38 CFRT 53 SBRT) 40 controls. Plasma were assessed using semi-targeted metabolomics, revealing 32 elevated 18 reduced metabolites patients. Key discriminatory included ethylmalonic acid, maltose, 3-phosphoglyceric taurine, glutamic glycocolic d-arabinose, a combined Receiver Operating Characteristics curve indicating perfect discrimination between SBRT affected different metabolites, but both changes suggested partial normalization energy amino acid metabolism pathways. In conclusion, metabolomics identified distinct metabolic signatures potential as diagnostic biomarkers. The differing responses to reflect their unique therapeutic impacts, underscoring utility this technique enhancing diagnosis treatment monitoring.

Language: Английский

Citations

2
Combining Metabolomics and Machine Learning to Identify Diagnostic and Prognostic Biomarkers in Patients with Non-Small Cell Lung Cancer Pre- and Post-Radiation Therapy DOI Open Access
M. Murcia, Marta Canela-Capdevila,

Raquel García-Pablo

et al.

Published: June 17, 2024

Lung cancer is the leading cause of cancer-related deaths globally, with non-small cell lung (NSCLC) accounting for over 85% cases and poor prognosis in advanced stages. This study explored shifts circulating metabolite levels NSCLC patients versus healthy controls examined effects conventionally fractionated radiation therapy (CFRT) stereotactic body (SBRT). We enrolled 91 (38 CFRT 53 SBRT) 40 controls. Plasma were assessed using semi-targeted metabolomics, revealing 32 elevated 18 reduced metabolites patients. Key discriminatory included ethylmalonic acid, maltose, 3-phosphoglyceric taurine, glutamic glycocolic d-arabinose, a combined Receiver Operating Characteristics curve indicating perfect discrimination between SBRT affected different metabolites, but both changes suggested partial normalization energy amino acid metabolism pathways. In conclusion, metabolomics identified distinct metabolic signatures potential as diagnostic biomarkers. The differing responses to reflect their unique therapeutic impacts, underscoring utility this technique enhancing diagnosis treatment monitoring.

Language: Английский

Citations

1
Regulation of Gut Microbiota-Derived GABA: Impact of Intestinal pH, Osmolality, and Microbial Consumption DOI Creative Commons
Benoı̂t Pugin, Kun Ye,

Serafina Plüss

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract The production of gamma-aminobutyric acid (GABA) by the gut microbiota has garnered attention due to its potential role in gut-brain axis. However, regulatory mechanisms governing microbiota-derived GABA under physiologically relevant conditions remain unclear. Here, using model GABA-producing microbe Bacteroides thetaiotaomicron, we identified intestinal environmental factors that modulate production. We demonstrate low pH and high osmolality promote driving changes expression glutamate decarboxylase system. Notably, emerged as a critical factor for enhancing across diverse microbes. complex microbial communities, such cecum specific pathogen-free mice an ex vivo human colon model, levels did not increase acidic conditions. This was partly consumption GABA-utilizing bacteria. Consistently, reducing cecal increased Oligo-MM12 mice, gnotobiotic lacking GABA-consuming strains. Our findings highlight intricate balance between production, consumption, osmolality.

Language: Английский

Citations

0
The Release of Organic Acids and Low Molecular Weight Carbohydrates from Matcha Tea After In Vitro Digestion DOI Open Access
Jiří Nekvapil, Daniela Sumczynski, Richardos Nikolaos Salek

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4058 - 4058

Published: Nov. 26, 2024

Background/Objectives: This study tested the influence of in vitro digestion on release organic acids and low molecular weight saccharides matcha. Methods: The concentrations analytes raw undigested portion matcha were measured using HPLC with spectrometric refractometric detection to establish their residual values after a two-step enzymatic that was finally presented as retention factor. Results: It established dry matter digestibility simulated gastric both intestinal phases 67.3 85.9%, respectively. Native matcha, citric acid (44.8 mg/g), malic (32.2 trehalose (36.1 L-arabinose (8.20 mg/g) reached highest predominant, whereas D-fructose, xylose, maltose, saccharose not detected. Regarding phase digestion, succinic acids, D-glucose worst-releasing compounds remaining factors 34, 19, 18, 50%, respectively, completely released. Focusing small least-releasing tea leaves trehalose, at 7 13%, which can proceed leaf matrix large intestine. Conclusions: Malic, oxalic, carbohydrates D-glucose, L-arabinose, L-rhamnose, are almost entirely released from during stomach intestine be available for absorption In measurement oxalic acid, considering process shading increases concentration this its factor value is too small, it would appropriate future evaluate recommended maximum daily intake people sensitive formation urinal stones.

Language: Английский

Citations

0
Detecting N-Phenyl-2-Naphthylamine, L-Arabinose, D-Mannose, L-Phenylalanine, L-Methionine, and D-Trehalose via Photocurrent Measurement DOI Creative Commons
Feng Li, Ruoxi Yang, Jian Xu

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 808 - 808

Published: Dec. 9, 2024

The concentration of small molecules reflects the normality physiological processes in human body, making development simple and efficient detection equipment essential. In this work, inspired by a facile strategy point-of-care detection, two devices were fabricated to detect via photocurrent measurement. A linear response against was found. first device, metal ions introduced into gel substrates made xanthan gum enhance response. N-phenyl-2-naphthylamine measured when iron or manganese used. L-Phenylalanine modified samarium, iron, cerium, ytterbium ions. L-(+)-Arabinose detected gels holmium D-(+)-Mannose ytterbium, manganese, chromium, sodium L-Methionine zinc, chromium second device based on paper sheet. sugar-like molecule synthesized, which then used modify paper. possible since showed trend D-Trehalose. fit conducted derive sensitivity, whose value found be 5542.4. This work offers novel, simple, environmentally sustainable platform that is potentially useful remote areas lacking medical devices.

Language: Английский

Citations

0