Integrated microbiome and metabolomics analysis reveals the alleviating effect of Pediococcus acidilactici on colitis DOI Creative Commons

Lulu Wu,

L. F. Xue,

Xin Ding

et al.

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 26, 2025

Colitis is a complicated disease caused by multiple factors, seriously threatening the host health and development of animal husbandry. Probiotics have been demonstrate to participate in active regulation gastrointestinal disease, gut microbiota metabolism, but research on efficacy Pediococcus acidilactici isolated from dogs alleviating colitis remains scarce. Here, we aimed investigate ameliorative effects induced LPS its underlying molecular mechanisms. For this purpose, collected colon contents 15 mice for amplicon sequencing metabolic analysis. Results showed that could relieve damage cytokine disorder colitis. Microbiome analysis cause significant decrease microbial diversity abundance, administration restore index control level. Metabolomics 8 pathways 5 (spermine, L-Arginine, 15-Deoxy-Delta12,14-PGJ2, prostaglandin J2, 15(S)-HETE) metabolites may be involved alleviation acidilactici. In summary, these findings demonstrated positive effect metabolism one mechanisms alleviate Additionally, study also conveyed vital message serve as promising candidate ameliorate

Language: Английский

Integrated microbiome and metabolomics analysis reveals the alleviating effect of Pediococcus acidilactici on colitis DOI Creative Commons

Lulu Wu,

L. F. Xue,

Xin Ding

et al.

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 26, 2025

Colitis is a complicated disease caused by multiple factors, seriously threatening the host health and development of animal husbandry. Probiotics have been demonstrate to participate in active regulation gastrointestinal disease, gut microbiota metabolism, but research on efficacy Pediococcus acidilactici isolated from dogs alleviating colitis remains scarce. Here, we aimed investigate ameliorative effects induced LPS its underlying molecular mechanisms. For this purpose, collected colon contents 15 mice for amplicon sequencing metabolic analysis. Results showed that could relieve damage cytokine disorder colitis. Microbiome analysis cause significant decrease microbial diversity abundance, administration restore index control level. Metabolomics 8 pathways 5 (spermine, L-Arginine, 15-Deoxy-Delta12,14-PGJ2, prostaglandin J2, 15(S)-HETE) metabolites may be involved alleviation acidilactici. In summary, these findings demonstrated positive effect metabolism one mechanisms alleviate Additionally, study also conveyed vital message serve as promising candidate ameliorate

Language: Английский

Citations

0