Unveiling the Gut-Disc Axis: How Microbiome Dysbiosis Accelerates Intervertebral Disc Degeneration DOI Creative Commons

Yu Sun,

Zhaoyong Li, Jiahao Duan

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 8271 - 8280

Published: Nov. 1, 2024

Abstract: The gut microbiome (GM), often referred to as the second genome of human body, plays a crucial role in various metabolic processes and mediates development numerous diseases. Intervertebral disc degeneration (IDD) is an age-related degenerative spinal disease characterized by loss height, hydration, integrity, leading pain reduced mobility. Although pathogenesis IDD not fully understood, recent studies suggest that dysbiosis may accelerate progression through multiple mechanisms. This article begins discussing potential relationship between GM diseases, followed comprehensive review regulatory mechanisms skeletal diseases within gut-disc axis framework. Furthermore, it explores three pathways which mediate IDD: immunomodulation, bacterial translocation colonization, decomposition absorption intestinal metabolites. These can disrupt cell homeostasis promote changes. Finally, this paper summarizes for first time therapeutic approaches delaying targeting axis, providing new insights into regenerative repair strategies IDD. Keywords: intervertebral degeneration, microbiome, inflammation, immunity, metabolism

Language: Английский

Applications of bacteriophages in precision engineering of the human gut microbiome DOI Creative Commons

Xiaoxian Kuang,

Juntao Shen,

Linggang Zheng

et al.

Engineering Microbiology, Journal Year: 2025, Volume and Issue: 5(1), P. 100189 - 100189

Published: Jan. 7, 2025

Language: Английский

Citations

0
Precision microbial regulation: Strategies for modulating GIT microbiota for host health DOI Creative Commons

Zhong Pei,

Qin Li, Yanmei Zhang

et al.

iMetaOmics., Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Recent advancements in analytical techniques have unveiled the spatiotemporal diversity of gastrointestinal tract (GIT) microbiota and their associations with host well‐being. Despite these insights, precise regulation GIT remains a significant challenge. Currently, microbial regulatory strategies, including fecal transplantation (FMT), synthetic communities (SynComs), genetically engineered microorganisms (GEMs), phages, nanomaterials, are increasingly utilized for influence on microbiota. This review emphasizes necessity developing targeted strategies provides comprehensive summary comparison approaches to explore potential. We discuss recent focusing mechanisms, efficacy, safety considerations, clinical trials, optimization at application level. Finally, we highlight support methods optimizing modulation timing regulation, selection targets, importance monitoring environment guide effective interventions.

Language: Английский

Citations

0
Interactions between environmental pollutants and gut microbiota: a review connecting the conventional heavy metals and the emerging microplastics DOI
Xiaochen Chen,

Zeng-Di Zhang,

Yu‐Mei Hsueh

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 120928 - 120928

Published: Jan. 1, 2025

Language: Английский

Citations

0
Operationalizing Team Science at the Academic Cancer Center Network to Unveil the Structure and Function of the Gut Microbiome DOI Open Access
Kevin McDonnell

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 2040 - 2040

Published: March 17, 2025

Oncologists increasingly recognize the microbiome as an important facilitator of health well a contributor to disease, including, specifically, cancer. Our knowledge etiologies, mechanisms, and modulation states that ameliorate or promote cancer continues evolve. The progressive refinement adoption “omic” technologies (genomics, transcriptomics, proteomics, metabolomics) utilization advanced computational methods accelerate this evolution. academic center network, with its immediate access extensive, multidisciplinary expertise scientific resources, has potential catalyze research. Here, we review our current understanding role gut in prevention, predisposition, response therapy. We underscore promise operationalizing network uncover structure function microbiome; highlight unique microbiome-related expert resources available at City Hope Comprehensive Cancer Center example team science achieve novel clinical discovery.

Language: Английский

Citations

0
Unveiling the Gut-Disc Axis: How Microbiome Dysbiosis Accelerates Intervertebral Disc Degeneration DOI Creative Commons

Yu Sun,

Zhaoyong Li, Jiahao Duan

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 8271 - 8280

Published: Nov. 1, 2024

Abstract: The gut microbiome (GM), often referred to as the second genome of human body, plays a crucial role in various metabolic processes and mediates development numerous diseases. Intervertebral disc degeneration (IDD) is an age-related degenerative spinal disease characterized by loss height, hydration, integrity, leading pain reduced mobility. Although pathogenesis IDD not fully understood, recent studies suggest that dysbiosis may accelerate progression through multiple mechanisms. This article begins discussing potential relationship between GM diseases, followed comprehensive review regulatory mechanisms skeletal diseases within gut-disc axis framework. Furthermore, it explores three pathways which mediate IDD: immunomodulation, bacterial translocation colonization, decomposition absorption intestinal metabolites. These can disrupt cell homeostasis promote changes. Finally, this paper summarizes for first time therapeutic approaches delaying targeting axis, providing new insights into regenerative repair strategies IDD. Keywords: intervertebral degeneration, microbiome, inflammation, immunity, metabolism

Language: Английский

Citations

2