YHSeqY3000 panel captures all founding lineages in the Chinese paternal genomic diversity database DOI Creative Commons
Mengge Wang,

Shuhan Duan,

Qiuxia Sun

et al.

BMC Biology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 21, 2025

The advancements in second-/third-generation sequencing technologies, alongside computational innovations, have significantly enhanced our understanding of the genomic structure Y-chromosomes and their unique phylogenetic characteristics. These researches, despite challenges posed by lack population-scale databases, potential to revolutionize approach high-resolution, population-specific Y-chromosome panels databases for anthropological forensic applications. This study aimed develop highest-resolution Y-targeted panel, utilizing time-stamped, core informative mutations identified from high-coverage sequences YanHuang cohort. panel is intended provide a new tool complex pedigree search paternal biogeographical ancestry inference, as well explore general patterns fine-scale evolutionary history ethnolinguistically diverse Chinese populations. performance East Asian-specific Y-chromosomal including 2999-core SNP variants, was found be robust reliable. YHSeqY3000 designed capture genetic diversity lineages 3500 years ago, identifying 408 terminal 2097 individuals across 41 genetically geographically distinct We substructure that correlating with ancient population migrations expansions. New evidence provided extensive gene flow events between minority ethnic groups Han people, based on integrative Paternal Genomic Diversity Database. work successfully integrated Y-chromosome-related basic science translational applications, emphasizing necessity comprehensively characterizing genomically under-representative particularly important second phase medical or cohorts, where dense sampling strategies are employed.

Language: Английский

Perspectives and opportunities in forensic human, animal, and plant integrative genomics in the Pangenome era DOI
Guanglin He, Chao Liu,

Mengge Wang

et al.

Forensic Science International, Journal Year: 2025, Volume and Issue: 367, P. 112370 - 112370

Published: Jan. 12, 2025

Language: Английский

Citations

0
YHSeqY3000 panel captures all founding lineages in the Chinese paternal genomic diversity database DOI Creative Commons
Mengge Wang,

Shuhan Duan,

Qiuxia Sun

et al.

BMC Biology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 21, 2025

The advancements in second-/third-generation sequencing technologies, alongside computational innovations, have significantly enhanced our understanding of the genomic structure Y-chromosomes and their unique phylogenetic characteristics. These researches, despite challenges posed by lack population-scale databases, potential to revolutionize approach high-resolution, population-specific Y-chromosome panels databases for anthropological forensic applications. This study aimed develop highest-resolution Y-targeted panel, utilizing time-stamped, core informative mutations identified from high-coverage sequences YanHuang cohort. panel is intended provide a new tool complex pedigree search paternal biogeographical ancestry inference, as well explore general patterns fine-scale evolutionary history ethnolinguistically diverse Chinese populations. performance East Asian-specific Y-chromosomal including 2999-core SNP variants, was found be robust reliable. YHSeqY3000 designed capture genetic diversity lineages 3500 years ago, identifying 408 terminal 2097 individuals across 41 genetically geographically distinct We substructure that correlating with ancient population migrations expansions. New evidence provided extensive gene flow events between minority ethnic groups Han people, based on integrative Paternal Genomic Diversity Database. work successfully integrated Y-chromosome-related basic science translational applications, emphasizing necessity comprehensively characterizing genomically under-representative particularly important second phase medical or cohorts, where dense sampling strategies are employed.

Language: Английский

Citations

0