Trends in the use of granulocyte colony stimulating factors for older patients with cancer, 2010 to 2019 DOI

Kaylee Fish,

Daoqi Gao,

Mukaila Raji

et al.

Journal of Geriatric Oncology, Journal Year: 2024, Volume and Issue: 15(8), P. 102049 - 102049

Published: Sept. 2, 2024

Language: Английский

The Role of Fibroblasts in Skin Homeostasis and Repair DOI Creative Commons
Federica Boraldi, Francesco Demetrio Lofaro,

Susanna Bonacorsi

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1586 - 1586

Published: July 17, 2024

Fibroblasts are typical mesenchymal cells widely distributed throughout the human body where they (1) synthesise and maintain extracellular matrix, ensuring structural role of soft connective tissues; (2) secrete cytokines growth factors; (3) communicate with each other cell types, acting as signalling source for stem niches; (4) involved in tissue remodelling, wound healing, fibrosis, cancer. This review focuses on developmental heterogeneity dermal fibroblasts, their ability to sense changes biomechanical properties surrounding aging, skin repair, pathologic conditions tumour development. Moreover, we describe use fibroblasts different models (e.g., vivo animal vitro systems from 2D 6D cultures) bioengineering informative potential high-throughput assays study under disease contexts personalized healthcare regenerative medicine applications.

Language: Английский

Citations

16
Oleanolic Acid Slows Down Aging Through IGF-1 Affecting the PI3K/AKT/mTOR Signaling Pathway DOI Creative Commons
Yan Xu, Jun Wei, Wang Wang

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 740 - 740

Published: Feb. 6, 2025

A pentacyclic triterpene, oleanolic acid (OA), has anti-inflammatory activity. The role of in aging is poorly understood, and the regulatory mechanism IGF-1 signaling still not fully understood. Thus, we hypothesized that OA could delay by regulating PI3K/AKT/mTOR pathway via insulin-like growth factor-1 (IGF-1). This study initially established a replicative model bleomycin-induced human dermal fibroblast (HDF) mouse embryonic (MEF) cell lines. On this basis, inhibitors or recombinant proteins were then combined with (at concentration 20 μM) treated for 72 h. project plans to detect expression aging-related such as CDKN2A (p16) using Western blot technology, factors Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8) Real-Time Quantitative Polymerase Chain Reaction (RT-qPCR), Enzyme-Linked Immunosorbent Assay (ELISA), other technologies, combine Senescence-Associated β-Galactosidase (SA-β-gal) staining changes aging. IGF-1, PI3K/AKT/mTOR, P16, secretory (SASP) IL-1β, IL-6, IL-8 was increased senescent cells. After treatment jujuboside, protein decreased. findings suggested slowed down inhibiting through IGF-1. These suggest potential new drug its mechanisms anti-aging.

Language: Английский

Citations

0
Senotherapeutics: Milestones, innovations, and future prospects DOI
Erdem Atasever, Mehmet Can Atayik, Ufuk Çakatay

et al.

Advances in pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Cellular oxidative stress and sirtuins mediate regulation of senescence and neuronal differentiation by withaferin A DOI
Keshava Prasad, Sunil C. Kaul, Renu Wadhwa

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Impact of immunological aging on T cell-mediated therapies in older adults with multiple myeloma and lymphoma DOI Creative Commons
Fabian Ullrich, Paul J. Bröckelmann, Amin T. Turki

et al.

Journal for ImmunoTherapy of Cancer, Journal Year: 2024, Volume and Issue: 12(12), P. e009462 - e009462

Published: Dec. 1, 2024

The treatment landscape for lymphoma and multiple myeloma, which disproportionally affect older adults, has been transformed by the advent of T cell-mediated immunotherapies, including immune checkpoint inhibition, cell-engaging bispecific antibodies, chimeric antigen receptor (CAR) cell therapy, during last decade. These modalities re-enable patient’s own system to combat malignant cells offer potential sustained remissions cure various diseases. Age profoundly affects physiological function system. process biological aging is largely driven inflammatory signaling, reciprocally fueled aging-related alterations physiology metabolism. In compartment, contributes senescence exhaustion, increased abundance terminally differentiated cells, a corresponding attrition in naïve numbers, decrease breadth repertoire. Furthermore, signaling drives pathologies frailty individuals. Thus, there growing evidence modulating efficacy toxicity immunotherapies. Here, we review available from clinical studies focusing on relationship between hematologic malignancies age. We discuss features potentially impacting outcomes scenarios, strategies improve safety inhibitors, CAR-T therapy patients.

Language: Английский

Citations

1
Trends in the use of granulocyte colony stimulating factors for older patients with cancer, 2010 to 2019 DOI

Kaylee Fish,

Daoqi Gao,

Mukaila Raji

et al.

Journal of Geriatric Oncology, Journal Year: 2024, Volume and Issue: 15(8), P. 102049 - 102049

Published: Sept. 2, 2024

Language: Английский

Citations

0