Phytotherapy Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
ABSTRACT
Obesity,
along
with
its
associated
health
risks
such
as
hypertension,
hyperlipidemia,
Type
2
diabetes,
stroke,
metabolic
syndrome,
asthma,
and
cancer,
constitutes
a
significant
global
burden,
contributing
substantially
to
morbidity
mortality.
Cytokines,
group
of
secreted
signaling
proteins,
are
crucial
in
initiating,
maintaining,
resolving
immune
responses.
Although
cytokines
have
unique
advantages
regulating
functions,
their
therapeutic
application
for
obesity
remains
limited
clinical
practice.
Natural
compounds,
known
structural
diversity
low
toxicity,
become
valuable
resource
drug
development.
Many
natural
compounds
shown
anti‐obesity
effects.
This
review
comprehensively
examines
the
mechanisms
underlying
obesity,
specific
focus
on
roles
cytokines,
inflammatory
adipokines,
growth
factors.
Additionally,
it
highlights
regulatory
interactions
between
gut
microbiota
obesity.
The
critically
analyzes
current
pharmacological
interventions
summarizes
advanced
methodologies
identifying
potential
compounds.
Finally,
identifies
promising
that
modulate
cytokine
activity
prevent
or
treat
assesses
complementary
alternative
therapies.
Journal of Ginseng Research,
Journal Year:
2024,
Volume and Issue:
48(4), P. 354 - 365
Published: April 21, 2024
Panax
species
include
ginseng
Meyer,
quinquefolium
L.,
notoginseng,
japonicum,
trifolium,
and
pseudoginseng,
which
contain
bioactive
components
(BCs)
such
as
ginsenosides
polysaccharides.
Recently,
growing
evidence
has
revealed
the
pharmacological
effects
of
their
BCs
on
allergic
airway
diseases
(AADs),
including
asthma
(AA)
rhinitis
(AR).
AADs
are
characterized
by
damaged
epithelium,
sustained
acquired
immune
responses
with
enforced
Th2
responses,
allergen-specific
IgE
production,
enhanced
production
histamine
leukotrienes
activated
mast
cells
basophils.
In
this
review,
we
summarize
how
modulate
involving
interactions
between
dendritic
T
cells,
reduce
pro-inflammatory
epithelial
allergenic
from
basophils
in
vitro.
addition,
highlight
current
understanding
alleviative
against
AA
AR
vivo.
Moreover,
discuss
unmet
needs
research
considerations
for
treatment
patients
to
provide
basic
scientific
knowledge
using
BCs.
Phytotherapy Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
ABSTRACT
Obesity,
along
with
its
associated
health
risks
such
as
hypertension,
hyperlipidemia,
Type
2
diabetes,
stroke,
metabolic
syndrome,
asthma,
and
cancer,
constitutes
a
significant
global
burden,
contributing
substantially
to
morbidity
mortality.
Cytokines,
group
of
secreted
signaling
proteins,
are
crucial
in
initiating,
maintaining,
resolving
immune
responses.
Although
cytokines
have
unique
advantages
regulating
functions,
their
therapeutic
application
for
obesity
remains
limited
clinical
practice.
Natural
compounds,
known
structural
diversity
low
toxicity,
become
valuable
resource
drug
development.
Many
natural
compounds
shown
anti‐obesity
effects.
This
review
comprehensively
examines
the
mechanisms
underlying
obesity,
specific
focus
on
roles
cytokines,
inflammatory
adipokines,
growth
factors.
Additionally,
it
highlights
regulatory
interactions
between
gut
microbiota
obesity.
The
critically
analyzes
current
pharmacological
interventions
summarizes
advanced
methodologies
identifying
potential
compounds.
Finally,
identifies
promising
that
modulate
cytokine
activity
prevent
or
treat
assesses
complementary
alternative
therapies.
