Ameliorative Effects of Korean-Red-Ginseng-Derived Polysaccharide on Antibiotic-Associated Diarrhea DOI Open Access

Su Ji Min,

Hiyoung Kim,

Noriko Yambe

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(2), P. 231 - 231

Published: Jan. 14, 2024

This study evaluated the ameliorative effects of Korean-red-ginseng-derived polysaccharide (KRG-P) on antibiotic-associated diarrhea (AAD) induced by administering lincomycin in mice. Changes intestinal barrier proteins, microbiome and short-chain fatty acid (SCFA) contents were investigated. Lincomycin was orally administered for 9 days to induce diarrhea; subsequently, 100 mg/kg 300 KRG-P 12 days. The observed AAD group; further administration improved diarrhea. Analysis changes microbial flora mice revealed that harmful bacterial (such as Proteobacteria) increased group, whereas beneficial Firmicutes) decreased. However, resulted decreased Proteobacteria Firmicutes, supporting improvement imbalance caused AAD. Moreover, an analysis SCFAs (acetic acid, propionic butylic acid) caecum SCFAs’ group substantially reduced but tended increase upon administration. Based these results, KRG-P, which is primarily composed carbohydrates can improve lincomycin-induced diarrhea, likely owing recovery SCFA content improving proteins.

Language: Английский

Ameliorative Effects of Korean-Red-Ginseng-Derived Polysaccharide on Antibiotic-Associated Diarrhea DOI Open Access

Su Ji Min,

Hiyoung Kim,

Noriko Yambe

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(2), P. 231 - 231

Published: Jan. 14, 2024

This study evaluated the ameliorative effects of Korean-red-ginseng-derived polysaccharide (KRG-P) on antibiotic-associated diarrhea (AAD) induced by administering lincomycin in mice. Changes intestinal barrier proteins, microbiome and short-chain fatty acid (SCFA) contents were investigated. Lincomycin was orally administered for 9 days to induce diarrhea; subsequently, 100 mg/kg 300 KRG-P 12 days. The observed AAD group; further administration improved diarrhea. Analysis changes microbial flora mice revealed that harmful bacterial (such as Proteobacteria) increased group, whereas beneficial Firmicutes) decreased. However, resulted decreased Proteobacteria Firmicutes, supporting improvement imbalance caused AAD. Moreover, an analysis SCFAs (acetic acid, propionic butylic acid) caecum SCFAs’ group substantially reduced but tended increase upon administration. Based these results, KRG-P, which is primarily composed carbohydrates can improve lincomycin-induced diarrhea, likely owing recovery SCFA content improving proteins.

Language: Английский

Citations

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