Biology,
Journal Year:
2023,
Volume and Issue:
12(6), P. 798 - 798
Published: May 31, 2023
The
sea
cucumber,
Apostichopus
japonicus,
is
a
marine
benthic
organism
that
feeds
on
small
particulate
matter
and
easily
affected
by
pollutants.
Bisphenol
A
(BPA,
4,4'-isopropylidenediphenol)
has
been
identified
as
an
endocrine
disruptor.
It
ubiquitously
detectable
in
oceans
affects
variety
of
animals.
functions
estrogen
analog
typically
causes
reproductive
toxicity
interfering
with
the
system.
To
comparatively
analyze
effects
estradiol
(E2)
BPA
cucumbers,
we
G
protein-coupled
receptor
1
(GPER1)
A.
japonicus
investigated
its
reproduction.
results
showed
E2
exposure
activated
AjGPER1,
thereby
mediating
mitogen-activated
protein
kinase
signaling
pathways.
High-level
expression
AjGPER1
ovarian
tissue
was
confirmed
qPCR.
Furthermore,
metabolic
changes
were
induced
100
nM
(22.83
μg/L)
tissue,
leading
to
notable
increase
activities
trehalase
phosphofructokinase.
Overall,
our
findings
suggest
directly
cucumber
reproduction
disrupting
metabolism,
suggesting
pollutants
pose
threat
conservation
resources.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(12), P. 6403 - 6403
Published: June 15, 2021
Insulin
is
a
polypeptide
hormone
mainly
secreted
by
β
cells
in
the
islets
of
Langerhans
pancreas.
The
potentially
coordinates
with
glucagon
to
modulate
blood
glucose
levels;
insulin
acts
via
an
anabolic
pathway,
while
performs
catabolic
functions.
regulates
levels
bloodstream
and
induces
storage
liver,
muscles,
adipose
tissue,
resulting
overall
weight
gain.
modulation
wide
range
physiological
processes
makes
its
synthesis
critical
onset
progression
several
chronic
diseases.
Although
clinical
basic
research
has
made
significant
progress
understanding
role
pathophysiological
processes,
many
aspects
these
functions
have
yet
be
elucidated.
This
review
provides
update
on
secretion
regulation,
roles
different
organs
cells,
implications
health.
We
cast
light
recent
advances
insulin-signaling
targeted
therapies,
protective
effects
signaling
activators
against
disease,
recommendations
directions
for
future
research.
Biomedicines,
Journal Year:
2021,
Volume and Issue:
9(6), P. 666 - 666
Published: June 10, 2021
Bisphenol
A
is
a
compound
commonly
found
in
products
meant
for
daily
use.
It
was
one
of
the
first
compounds
to
be
identified
as
an
endocrine
disruptor
that
capable
disrupting
system
and
producing
very
similar
effects
those
metabolic
syndrome.
has
recently
gained
popularity
scientific
arena
risk
factor
obesity
diabetes
due
its
ability
imitate
natural
oestrogens
bind
their
receptors.
The
aim
study
possible
relationship
between
with
obesity.
analysis
articles
allows
us
conclude
additional
consider
development
obesity,
since
it
stimulating
hypertrophy
adipocytes
altering
by
mimicking
oestrogen
molecule,
epidemiological
studies
carried
out
have
suggested
same
disruptions
seen
experimental
on
animals
can
humans;
however,
despite
many
countries
having
developed
policies
limit
exposure
this
populations,
there
lack
international
agreement.
Understanding
will
help
raise
awareness
population
adopt
public
health
campaigns
prevent
exposure-especially
among
young
people-to
these
substances.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
270, P. 115922 - 115922
Published: Jan. 1, 2024
Bisphenol
A
(BPA),
an
environmental
endocrine
disruptor
(EDC),
has
been
implicated
in
impairing
intestinal
and
male
reproductive
dysfunction.
The
efficacy
of
gut
microbiota
modulation
for
BPA-exposed
testicular
dysfunction
yet
to
be
verified
through
research.
Therefore,
this
study
explored
the
potential
mixed
probiotics
restoring
spermatogenesis
damage
gut-testis
axis
under
BPA
exposure.
We
selected
two
strains
(Lactobacillus
rhamnosus
Lactobacillus
plantarum)
with
removal
properties
vitro
mice
model
was
established.
mixture
effectively
reduced
residue
gut,
serum,
testis
mice.
Through
16
S
rDNA-seq
metabolomics
sequencing,
we
uncovered
that
vitamin
D
metabolism
bile
acid
levels
abolished
This
perturbation
linked
increased
abundance
Faecalibaculum
decreased
Lachnospiraceae_NK4A136_group
Ligilactobacillus.
restored
balance,
enhancing
barrier
function
reducing
oxidative
stress.
improvement
accompanied
by
a
balance
short-chain
fatty
acids
(SCFAs).
Remarkably,
ameliorated
repairing
structures
seminiferous
tubules
reversing
arrested
spermiogenesis.
Further,
enhanced
testosterone-driven
increases
spermatogonial
stem
cells
all
stages
sperm
cells.
Testicular
transcriptome
profiling
these
improvements
degradation
peroxisome
pathways.
These
findings
suggest
significant
interplay
between
microbiota,
demonstrating
probiotic
intake
could
viable
strategy
combating
subfertility
issues
caused
