Reproductive Toxicology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 108550 - 108550
Published: Jan. 1, 2024
Particulate
matter
2.5
(PM2.5)
is
associated
with
reproductive
health
and
adverse
pregnancy
outcomes.
However,
studies
evaluating
biological
markers
of
PM2.5
are
lacking,
identifying
biomarkers
for
estimating
prenatal
exposure
to
prevent
complications
essential.
Therefore,
we
aimed
explore
urine
metabolites
that
easy
measure
as
exposure.
In
this
matched
case-control
study
based
on
the
exposure,
30
high
group
(>15
μg/m3)
low
(<15
were
selected
from
air
pollution
outcome
(APPO)
cohort
study.
We
used
a
time-weighted
average
model
estimate
individual
PM
which
indoor
outdoor
concentrations
by
atmospheric
measurement
network
residential
addresses.
Clinical
characteristics
samples
collected
participants
during
second
trimester
pregnancy.
Urine
quantitatively
measured
using
gas
chromatography-mass
spectrometry
following
multistep
chemical
derivatization.
Statistical
analyses
conducted
SPSS
version
21
MetaboAnalyst
5.0.
Small
gestational
age
diabetes
(GDM)
significantly
increased
in
group,
respectively
(P=0.042,
0.022).
Fifteen
showed
significant
differences
between
two
groups
(P<0.05).
Subsequent
pathway
enrichment
revealed
four
pathways,
including
pentose
glucuronate
interconversion
three
sugars
(ribose,
arabinose,
xylose;
P<0.05).
The
concentration
ribose
preterm
births
(PTB)
GDM
(P=0.044
0.049,
respectively),
arabinose
tendency
increase
PTB
(P=0.044).
identified
urinary
confirmed
possibility
their
relationship
complications.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(4)
Published: July 14, 2023
Nanoparticles
(NPs)
have
become
one
of
the
most
popular
objects
scientific
study
during
past
decades.
However,
despite
wealth
reports,
still
there
is
a
gap,
particularly
in
health
toxicology
studies,
underlying
mechanisms,
and
related
evaluation
models
to
deeply
understanding
NPs
risk
effects.
In
this
review,
we
first
present
comprehensive
landscape
applications
on
health,
especially
addressing
role
medical
diagnosis,
therapy.
Then,
toxicity
systems
introduced.
We
describe
detail
effects
various
systems,
including
respiratory,
nervous,
endocrine,
immune,
reproductive
carcinogenicity
NPs.
Furthermore,
unravels
mechanisms
ROS
accumulation,
mitochondrial
damage,
inflammatory
reaction,
apoptosis,
DNA
cell
cycle,
epigenetic
regulation.
addition,
classical
such
as
lines
mice
emerging
3D
organoids
used
for
evaluating
or
are
both
Overall,
review
presents
critical
summary
state
NPs,
giving
readers
more
better
remedy
key
gaps
knowledge
techniques.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 12, 2024
Abstract
Background
In
the
context
of
increasing
exposure
to
silica
nanoparticles
(SiNPs)
and
ensuing
respiratory
health
risks,
emerging
evidence
has
suggested
that
SiNPs
can
cause
a
series
pathological
lung
injuries,
including
fibrotic
lesions.
However,
underlying
mediators
in
fibrogenesis
caused
by
have
not
yet
been
elucidated.
Results
The
vivo
investigation
verified
long-term
inhalation
induced
fibroblast
activation
collagen
deposition
rat
lungs
.
vitro,
uptake
exosomes
derived
from
SiNPs-stimulated
epithelial
cells
(BEAS-2B)
fibroblasts
(MRC-5)
enhanced
its
proliferation,
adhesion,
activation.
particular,
mechanistic
revealed
stimulated
an
increase
epithelium-secreted
exosomal
miR-494-3p
thereby
disrupted
TGF-β/BMPR2/Smad
pathway
via
targeting
bone
morphogenetic
protein
receptor
2
(BMPR2),
ultimately
resulting
deposition.
Conversely,
inhibitor
exosomes,
GW4869,
abolish
induction
upregulated
MRC-5
SiNPs-treated
supernatants
BEAS-2B.
Besides,
inhibiting
or
overexpression
BMPR2
could
ameliorate
interfering
with
pathway.
Conclusions
Our
data
pulmonary
epithelium-derived
serve
essential
role
upon
stimuli,
attributing
modulate
Hence,
strategies
be
new
avenue
developing
therapeutics
against
injury
elicited
SiNPs.
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