Unveiling Distribution of Per- and Polyfluoroalkyl Substances in Matched Placenta-Serum Tetrads: Novel Implications for Birth Outcome Mediated by Placental Vascular Disruption DOI
Di Ji, Yitao Pan, Xuelin Qiu

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(14), P. 5782 - 5793

Published: March 29, 2023

The placenta is pivotal for fetal development and maternal–fetal transfer of many substances, including per- polyfluoroalkyl substances (PFASs). However, the intraplacental distribution PFASs their effects on placental vascular function remain unclear. In this study, 302 tetrads matched subchorionic (fetal-side), parabasal (maternal-side), cord serum, maternal serum samples were collected from Guangzhou, China. Eighteen emerging legacy five biomarkers measured. Results showed that higher levels perfluorooctanoic (PFOA), perfluorooctane sulfonic acid (PFOS), chlorinated polyfluorinated ether acids (Cl-PFESAs) detected in compared to placenta. There significant associations placenta, but not with (up 32.5%) lower birth size. Birth weight was negatively associated PFOA (β: −103.8, 95% CI: −186.3 −21.32) 6:2 Cl-PFESA −80.04, −139.5 −20.61), primarily Mediation altered angiopoietin-2 endothelial growth factor receptor-2 evidenced adverse outcomes PFOS 8:2 Cl-PFESA, explaining 9.5%–32.5% total effect. To best our knowledge, study first report differential mediating provides novel insights into plate-specific measurement PFAS-associated health risk assessment.

Language: Английский

Designing smart anti-theft alarm system via lead-free BSFO-PDMS composite based triboelectric nanogenerator DOI
Reddicherla Umapathi, S.V.N. Pammi, Soobin Han

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161799 - 161799

Published: March 1, 2025

Language: Английский

Citations

1
Electrochemical-based approaches for the treatment of forever chemicals: Removal of perfluoroalkyl and polyfluoroalkyl substances (PFAS) from wastewater DOI

K. Sivagami,

Pranshu Sharma,

Ansaf V. Karim

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 861, P. 160440 - 160440

Published: Nov. 25, 2022

Language: Английский

Citations

35
Per- and polyfluoroalkyl substances in the atmosphere of waste management infrastructures: Uncovering secondary fluorotelomer alcohols, particle size distribution, and human inhalation exposure DOI Creative Commons
Huiju Lin, Jia-Yong Lao, Qi Wang

et al.

Environment International, Journal Year: 2022, Volume and Issue: 167, P. 107434 - 107434

Published: July 26, 2022

Per- and polyfluoroalkyl substances (PFAS) have been applied in numerous industrial consumer products, the majority of which flow into waste management infrastructures (WMIs) at end their life cycles, but little is known about atmospheric releases PFAS from these facilities. In this study, we addressed key issue by investigating 49 PFAS, including 23 ionic 26 neutral precursor potential sources (n = 4; within or adjacent to WMIs) reference sites 2; coastal natural reserve sites) urban rural areas Hong Kong, China. Duplicate samples air size-segregated particulate matter were collected for 48 h continuously using a 11-stage Micro-Orifice Uniform Deposit Impactor (MOUDI). general, fluorotelomer alcohols (FTOHs) perfluoroalkane sulfonamides predominant classes found across sampling sites. We also demonstrated release several less frequently observed semivolatile intermediate products (e.g., secondary FTOHs) during treatment. Except perfluorooctane sulfonate, distributions exhibited heterogeneity sites, particularly WMIs, implying combined effects sorption affinity emission sources. A preliminary daily estimation revealed that landfill was relatively important source relative wastewater treatment plant. simplified International Commission on Radiological Protection model used estimate lung depositional fluxes, results showed inhaled mainly deposited head airway while fine ultrafine particles carried deeper alveoli. The cumulative inhalation dose gaseous ranged 81.9 265 pg/kg/d. In-depth research required understand health effect airborne workers WMIs.

Language: Английский

Citations

33
Aerobic Biotransformation and Defluorination of Fluoroalkylether Substances (ether PFAS): Substrate Specificity, Pathways, and Applications DOI Creative Commons
Bosen Jin, Yiwen Zhu,

Weiyang Zhao

et al.

Environmental Science & Technology Letters, Journal Year: 2023, Volume and Issue: 10(9), P. 755 - 761

Published: Aug. 7, 2023

Fluoroalkylether substances (ether PFAS) constitute a large group of emerging PFAS with uncertain environmental fate. Among them, GenX is the well-known alternative to perfluorooctanoic acid and one six proposed be regulated by U.S. Environmental Protection Agency. This study investigated structure-biodegradability relationship for 12 different ether carboxylic headgroup in activated sludge communities. Only polyfluorinated ethers at least -CH

Language: Английский

Citations

19
Unveiling Distribution of Per- and Polyfluoroalkyl Substances in Matched Placenta-Serum Tetrads: Novel Implications for Birth Outcome Mediated by Placental Vascular Disruption DOI
Di Ji, Yitao Pan, Xuelin Qiu

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(14), P. 5782 - 5793

Published: March 29, 2023

The placenta is pivotal for fetal development and maternal–fetal transfer of many substances, including per- polyfluoroalkyl substances (PFASs). However, the intraplacental distribution PFASs their effects on placental vascular function remain unclear. In this study, 302 tetrads matched subchorionic (fetal-side), parabasal (maternal-side), cord serum, maternal serum samples were collected from Guangzhou, China. Eighteen emerging legacy five biomarkers measured. Results showed that higher levels perfluorooctanoic (PFOA), perfluorooctane sulfonic acid (PFOS), chlorinated polyfluorinated ether acids (Cl-PFESAs) detected in compared to placenta. There significant associations placenta, but not with (up 32.5%) lower birth size. Birth weight was negatively associated PFOA (β: −103.8, 95% CI: −186.3 −21.32) 6:2 Cl-PFESA −80.04, −139.5 −20.61), primarily Mediation altered angiopoietin-2 endothelial growth factor receptor-2 evidenced adverse outcomes PFOS 8:2 Cl-PFESA, explaining 9.5%–32.5% total effect. To best our knowledge, study first report differential mediating provides novel insights into plate-specific measurement PFAS-associated health risk assessment.

Language: Английский

Citations

17