Metabolomics Reveal Nanoplastic-Induced Mitochondrial Damage in Human Liver and Lung Cells

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(17), P. 12483 - 12493

Published: Aug. 25, 2022

Plastic debris in the global biosphere is an increasing concern, and nanoplastic (NPs) toxicity humans far from being understood. Studies have indicated that NPs can affect mitochondria, but underlying mechanisms remain unclear. The liver lungs important metabolic functions are vulnerable to NP exposure. In this study, we investigated effects of 80 nm on mitochondrial pathways normal human hepatic (L02) cells lung (BEAS-2B) cells. exposure did not induce mass cell death; however, transmission electron microscopy analysis showed could enter cause damage, as evidenced by overproduction reactive oxygen species, alterations membrane potential, suppression respiration. These were observed at concentrations low 0.0125 mg/mL, which might be comparable environmental levels. Nontarget metabolomics confirmed most significantly impacted processes mitochondrial-related. function L02 was more than BEAS-2B cells, especially concentrations. This study identifies NP-induced dysfunction target providing insight into possibility adverse outcomes health.

Language: Английский

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Potential Health Impact of Microplastics: A Review of Environmental Distribution, Human Exposure, and Toxic Effects

Environment & Health, Journal Year: 2023, Volume and Issue: 1(4), P. 249 - 257

Published: Aug. 10, 2023

Microplastics are ubiquitous in the global environment. As a typical emerging pollutant, its potential health hazards have been widely concerning. In this brief paper, we introduce source, identification, toxicity, and hazard of microplastics human. The literature review shows that frequently detected environmental human samples. Humans potentially exposed to through oral intake, inhalation, skin contact. We summarize toxic effects experimental models like cells, organoids, animals. These consist oxidative stress, DNA damage, organ dysfunction, metabolic disorder, immune response, neurotoxicity, as well reproductive developmental toxicity. addition, epidemiological evidence suggests variety chronic diseases may be related exposure. Finally, put forward gaps toxicity research their future development directions. This will helpful understanding exposure risk microplastics.

Language: Английский

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Micro- and nano-plastics (MNPs) as emerging pollutant in ground water: Environmental impact, potential risks, limitations and way forward towards sustainable management

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 459, P. 141568 - 141568

Published: Jan. 27, 2023

Language: Английский

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Occurrence of microplastics in tap and bottled water, and food packaging: A narrative review on current knowledge

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 865, P. 161274 - 161274

Published: Dec. 29, 2022

Language: Английский

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Raman Microspectroscopy evidence of microplastics in human semen

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 901, P. 165922 - 165922

Published: July 31, 2023

The presence of microplastics (MPs) in human fluids and organs is a great concern, since, as highlighted by recent studies on animal models, they could cause alterations several physiological functions, including reproduction. In this study, semen samples collected from men living polluted area the Campania Region (Southern Italy), were analyzed to assess MPs. N. 16 pigmented microplastic fragments (ranging 2 6 μm size) with spheric or irregular shapes found six out ten samples. All detected MPs characterized terms morphology (size, colour, shape) chemical composition Raman Microspectroscopy. Chemical showed polypropylene (PP), polyethylene (PE), terephthalate (PET), polystyrene (PS), polyvinylchloride (PVC), polycarbonate (PC), polyoxymethylene (POM) acrylic, suggesting ingestion and/or inhalation route exposure environmental work, we propose for first time mechanism which pass into most likely through epididymis seminal vesicles, are susceptible inflammation.

Language: Английский

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Potential sources and occurrence of macro-plastics and microplastics pollution in farmland soils: A typical case of China

Critical Reviews in Environmental Science and Technology, Journal Year: 2023, Volume and Issue: 54(7), P. 533 - 556

Published: Sept. 23, 2023

AbstractPlastic debris (including macro-plastics, microplastics (MPs), and nanoplastics), defined as an emerging contaminant, has been proven to significantly affect soil ecosystem functioning. Accordingly, there is urgent need robustly quantify the pollution situation potential sources of plastics in soils. China leading producer user agricultural analyzed a typical case study highlight current farmland macro-plastics MPs. Our summarized information on occurrence abundance MPs Chinese soils for first time based 163 publications with 728 sample sites. The results showed that average concentration farmlands were 103 kg ha−1 4537 items kg−1 (dry soil), respectively. In addition, this synthesized latest scientific evidence Agricultural plastic films organic wastes are most reported sources, indicating they contribute Furthermore, modeling methods quantifying estimating stock flow materials within systems also summarized.Keywords: Abundancefarmland soilsmacro-plasticsmicroplasticsquantitative methodsource apportionmentHANDLING EDITORS: Hyunjung Kim Jörg Rinklebe Disclosure statementThe authors report no competing interests declare.Additional informationFundingThis research was supported by National Natural Science Foundation under Grant [number 42277097]; UKRI Global Challenges Research Fund (GCRF) Environment Council project, "Do undermine food security sustainable development less economically developed countries?" [NE/V005871/1]; International Cooperation Exchange [NSFC-UNEP: 32261143459], High-level Team Project University.

Language: Английский

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A systematic review of the impacts of exposure to micro- and nano-plastics on human tissue accumulation and health

Eco-Environment & Health, Journal Year: 2023, Volume and Issue: 2(4), P. 195 - 207

Published: Aug. 21, 2023

Micro- and nano-plastics (MNPs) pollution has become a pressing global environmental issue, with growing concerns regarding its impact on human health. However, evidence the effects of MNPs health remains limited. This paper reviews three routes exposure to MNPs, which include ingestion, inhalation, dermal contact. It further discusses potential translocation in lungs, intestines, skin, analyses homeostasis organ systems, provides an outlook future research priorities for There is that are present tissues or fluids. Lab studies, including

Language: Английский

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Microplastics in three types of human arteries detected by pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS)

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 133855 - 133855

Published: Feb. 21, 2024

Language: Английский

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Prenatal and postnatal exposure to polystyrene microplastics induces testis developmental disorder and affects male fertility in mice

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 445, P. 130544 - 130544

Published: Dec. 5, 2022

Polystyrene microplastics (PS-MPs) can threaten human health, especially male fertility. However, most existing studies have focused on the adulthood stage of reproduction toxicity caused by relatively short-term PS-MP exposure. This study aimed to investigate toxic effect PS-MPs testicular development and reproductive function upon prenatal postnatal Pregnant mice their offspring were exposed 0, 0.5 mg/L, 5 50 mg/L through daily drinking water from gestational day 1 (PND) 35 or PND70. We found that exposure induced testis disorder PND35 spermatogenesis dysfunction By combining RNA sequencing results bioinformatics analysis, hormone-mediated signaling pathway, G1/S transition mitotic cell cycle, coregulation androgen receptor activity, Hippo pathway shown be involved in PND35. The meiotic regulation immune effector process, neutrophil degranulation, inflammation mediated chemokine cytokine pathways associated with disturbed These findings show resulted subfertility, which may regulated involve an reaction.

Language: Английский

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Microplastics: Human exposure assessment through air, water, and food

Environment International, Journal Year: 2023, Volume and Issue: 179, P. 108150 - 108150

Published: Aug. 14, 2023

Microplastics (MP) are plastic particles with dimension up to 5 mm. Due their persistence, global spread across different ecosystems and potential human health effects, they have gained increasing attention during the last decade. However, extent of exposure MP through pathways intake not been elucidated.The objective this review is provide an overview on inhalation, ingestion, dermal contact considering data from open bibliography in air, dust, food, water drinks.A bibliographic search Scopus PubMed was conducted using keywords outdoor indoor food including beverages (n = 521). Articles were sorted by title abstract 213), only studies reporting identification quantification techniques further considered 168). A total 115 articles that include quality assurance control (QA/QC) procedures finally discussed present review. Based concentration available literature, we estimated inhaled dose (ID), dust (DI), daily (EDI) via beverages. Finally, (TDI) both inhalation ingestion routes provided for adults, infants newborns.The concentrations according bibliography. Human air food/drinks consumption revealed drinking waters main sources MP.This study reveals humans constantly exposed MP, environment ingest decisively contribute intake. Additionally, highlight newborns high needed evaluate presence risk vulnerable age-population.

Language: Английский

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