MAPK/NF-κB signaling mediates atrazine-induced cardiorenal syndrome and antagonism of lycopene DOI
Fuwei Jiang, Jianying Guo,

Jia Lin

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 922, P. 171015 - 171015

Published: Feb. 16, 2024

Language: Английский

Bisphenol A induces apoptosis and disrupts testosterone synthesis in TM3 cells via reactive oxygen species-mediated mitochondrial pathway and autophagic flux inhibition DOI Creative Commons
Wenzhe Yang,

Feilong Pan,

Tong Zhao

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117691 - 117691

Published: Jan. 1, 2025

Bisphenol A (BPA) is a common endocrine disruptor chemical that widely used in the production of food plastic packaging, and it has been shown to potentially harm reproductive system. However, specific mechanism by which BPA induces apoptosis Leydig cells (LCs) inhibits testosterone synthesis these unclear. In present study, TM3 were as an experimental model combination with reactive oxygen species (ROS) scavenger (N-acetylcysteine), Caspase-3 inhibitor (Ac-DEVD-CHO), autophagy activator (Torin2), (Chloroquine) investigate potential mechanisms causes cell damage vitro. treatment increased ROS production, led marked decrease antioxidant enzyme activity expression levels antioxidant-related genes proteins cells. Upregulated cause excessive opening mitochondrial permeability transition pore significantly related membrane function The release cytochrome C from damaged mitochondria into cytoplasm activated Caspase cascade reaction. addition, impaired autophagic degradation inhibiting fusion autophagosomes lysosomes. These abnormalities eventually induced inhibited collective findings suggest interferes upregulating thereby activating apoptotic pathway flux. provide novel mechanistic insights male toxicity caused exposure.

Language: Английский

Citations

1
Assessing the impact of sub-chronic polyethylene terephthalate nanoplastic exposure on male reproductive health in mice DOI

Oğuz Kaan Tombul,

Arife Dilşad Akdağ,

Pınar Buket Thomas

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: 495, P. 117235 - 117235

Published: Jan. 19, 2025

Language: Английский

Citations

1
Exploring the reproductive exposure risks of phthalates and organophosphates in atmospheric particulate matter based on quantitative structure-activity relationships and network toxicology models DOI
Ke Gao,

Kai Hua,

Shiyuan Wang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137395 - 137395

Published: Jan. 1, 2025

Language: Английский

Citations

1
Disrupted microbiota-barrier-immune interaction in phthalates-mediated barrier defect in the duodenum DOI

Tian‐Ning Yang,

Xue‐Nan Li,

Yuxiang Wang

et al.

Chemosphere, Journal Year: 2022, Volume and Issue: 308, P. 136275 - 136275

Published: Sept. 1, 2022

Language: Английский

Citations

36
Heme-oxygenase-1 as a target for phthalate-induced cardiomyocytes ferroptosis DOI
Jiaxin Wang, Yi Zhao, Ming‐Shan Chen

et al.

Environmental Pollution, Journal Year: 2022, Volume and Issue: 317, P. 120717 - 120717

Published: Nov. 21, 2022

Language: Английский

Citations

35
Lycopene ameliorates DEHP exposure-induced renal pyroptosis through the Nrf2/Keap-1/NLRP3/Caspase-1 axis DOI
Muzi Li, Yi Zhao, Xueyan Dai

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2023, Volume and Issue: 113, P. 109266 - 109266

Published: Jan. 4, 2023

Language: Английский

Citations

20
Lycopene ameliorates atrazine-induced spatial learning and memory impairments by inhibiting ferroptosis in the hippocampus of mice DOI

Shi‐Yong Zhu,

Jun-Ze Jiang,

Jia Lin

et al.

Food and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 174, P. 113655 - 113655

Published: Feb. 13, 2023

Language: Английский

Citations

20
Cadmium aggravates the blood-brain barrier disruption via inhibition of the Wnt7A/β-catenin signaling axis DOI
Chenxi Li,

Milton Talukder,

Yaru Xu

et al.

Environmental Pollution, Journal Year: 2023, Volume and Issue: 324, P. 121400 - 121400

Published: March 4, 2023

Language: Английский

Citations

20
Transcriptome sequencing and metabolite analysis reveal the single and combined effects of microplastics and di-(2-ethylhexyl) phthalate on Peneaus vannamei DOI

Qiangqiang Shi,

Xiaoqian Zhang, Zeming Zhang

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 867, P. 161549 - 161549

Published: Jan. 11, 2023

Language: Английский

Citations

18
Novel Role of Hemeoxygenase-1 in Phthalate-Induced Renal Proximal Tubule Cell Ferroptosis DOI
Ming‐Shan Chen, Jiaxin Wang, Hao Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(5), P. 2579 - 2589

Published: Jan. 25, 2023

Phthalates are widely used to improve the flexibility of poly(vinyl chloride) (PVC) polymer agriculture products. Di(2-ethylhexyl) phthalate (DEHP) is a type addition plastic and can lead many health problems. Hemeoxygenase-1 (HO-1) an extremely important molecule that releases enzymatic products promote ferroptosis. This research aimed explore function HO-1 in DEHP-induced renal proximal tubule cell In experiment, ICR male mice exposed (0, 50, 200, 500 mg/kg BW/day) DEHP for 28 days. Here, we observed induced glomeruli atrophy tubules swell. Furthermore, exposure could increase ferrous iron content decrease antioxidant activity. We also found increased expression nuclear factor-erythroid 2 p45-related factor (NFE2L2) nucleus. particular, significantly both protein mRNA levels. Glutathione peroxidase 4 (GPX4) as endogenous control ferroptosis was downregulated, which proved occurrence study, activated NFE2L2/HO-1 signaling pathway resulted tubule. connects with HO-1, providing new insights into potential roles phthalates nephrotoxicity.

Language: Английский

Citations

18