Dual-Mode Lateral Flow Immunoassay Based on “Pompon Mum”-Like Fe₃O₄@MoS₂@Pt Nanotags for Sensitive Detection of Viral Pathogens

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(9), P. 11172 - 11184

Published: Feb. 22, 2024

Lateral flow immunoassay (LFIA) has been widely used for the early diagnosis of diseases. However, conventional colorimetric LFIA possesses limited sensitivity, and single-mode readout signal is easily affected by external environment, leading to insufficient accuracy. Herein, multifunctional Fe3O4@MoS2@Pt nanotags with a unique "pompon mum"-like structure were triumphantly prepared, exhibiting excellent peroxidase (POD)-like activity, photothermal properties, magnetic separation capability. Furthermore, establish dual-mode (dLFIA) first time, enabling catalytic detection severe acute respiratory syndrome coronavirus 2 nucleocapsid protein (SARS-CoV-2 NP) influenza A (H1N1). The calculated limits (cLODs) SARS-CoV-2 NP H1N1 80 20 ng/mL in mode 10 8 mode, respectively, demonstrating about 100 times more sensitive than commercial colloidal Au-LFIA strips (1 NP; 1 μg/mL H1N1). recovery rates dLFIA simulated nose swab samples 95.2–103.8% coefficient variance 2.3–10.1%. These results indicated that proposed platform showed great potential rapid viruses.

Language: Английский

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A Programmable Microfluidic Paper-Based Analytical Device for Simultaneous Colorimetric and Photothermal Visual Sensing of Multiple Enzyme Activities

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(29), P. 12181 - 12188

Published: July 8, 2024

New strategies for the simultaneous and portable detection of multiple enzyme activities are highly desirable clinical diagnosis home care. However, methods developed thus far generally suffer from high costs, cumbersome procedures, heavy reliance on large-scale instruments. To satisfy actual requirements rapid, accurate, on-site activities, we report herein a smartphone-assisted programmable microfluidic paper-based analytical device (μPAD) that utilizes colorimetric photothermal signals simultaneous, visual quantitative alkaline phosphatase (ALP) butyrylcholinesterase (BChE). Specifically, operation this μPAD sensing platform is based two sequential steps. Cobalt-doped mesoporous cerium oxide (Co-m-CeO

Language: Английский

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Carbon Quantum Dots: Basics, Properties, and Fundamentals

ACS symposium series, Journal Year: 2024, Volume and Issue: unknown, P. 3 - 42

Published: April 17, 2024

Carbon quantum dots (CQDs) belong to a remarkable category of nanocarbon materials with unique properties because their nanoscale dimensions. These nanocarbons have earned significant attention exceptional and advantages, making them versatile in wide range applications. This chapter delves into the fundamental principles underlying CQDs, along synthetic procedures outstanding characteristics. characteristics empower precise tuning optical electronic properties, setting stage for diverse Their pho­to­lu­mi­nes­cence—combined biocompatibility, water solubility, various surface functional groups—position CQDs as crucial components fields nanotechnology, science, medicine. As result, this highlights broad spectrum applications where made contributions 21st century.

Language: Английский

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Decorating Cage-Shaped Cavities with Carboxyl Groups on Two-Dimensional MOF Nanosheet for Trace Uranium(VI) Trapping

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(32), P. 15105 - 15114

Published: July 31, 2024

The efficient and complete extraction of uranium from aqueous solutions is crucial for safeguarding human health potential radiotoxicity chemotoxicity. Herein, an ultrathin 2D metal-organic framework (MOF) nanosheet with cavity structures was elaborately constructed, based on a calix[4]arene ligand. large molecular skeleton cup-shaped feature the enabled as-prepared MOFs layer separations, which can be readily delaminated into single-layer (∼1.25 nm) nanosheets. incorporation permanent to MOF nanosheets fully utilize their structural features accessible adsorption groups exposed surface area in removal, reaching ultrafast kinetics; functionalized structure endowed ability preconcentrate extract ultrahigh efficiencies, even at extremely low concentrations. As result, relatively high removal ratios (>95%) achieved within 5 min, ultralow concentration range 75-250 ppb, residual reduced below 4.9 ppb. also exhibited anti-interference ability, could efficiently remove low-level (∼150 ppb) various real samples. characterizations density functional theory calculations demonstrated that synergistic effects multiple interactions between carboxylate cage-like cavities uranyl ions responsible selective extraction.

Language: Английский

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A portable colorimetric sensing platform for rapid and sensitive quantification of dichlorvos pesticide based on Fe-Mn bimetallic oxide nanozyme-participated highly efficient chromogenic catalysis

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1292, P. 342243 - 342243

Published: Jan. 12, 2024

Language: Английский

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Photothermal detection of food hazards using temperature as an indicator: Principles, sensor developments and applications

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 146, P. 104393 - 104393

Published: Feb. 27, 2024

Photothermal sensing, due to its high resolution and spatial controllability, has gained significant attention in optical imaging for applications such as disease treatment diagnosis, environmental monitoring, etc. It effectively overcome the drawbacks of traditional sensors, susceptibility interference, cost, lack portability, strong dependency on operational procedures. conversion-based light-responsive temperature change sensors have been proven break limitations, serving an alternative strategy more potential applications, particularly detection hazardous substances food. In current review, principles generation photothermal materials corresponding representative are inducted modulation signals response-dependent principle rapid discussed. The practical food hazard outlook challenges faced also presented review. Various doped modified shown enable quantitative hazards through different signal mechanisms well relying non-specific, molecular biological immunological responses. is hoped that review can provide researchers with reference sources further developments effective sensitive safety assurance industry.

Language: Английский

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Sensitive colorimetric and fluorescence dual-mode detection of thiophanate-methyl based on spherical Fe3O4/GONRs composite nanozyme

Food Chemistry, Journal Year: 2024, Volume and Issue: 450, P. 139258 - 139258

Published: April 5, 2024

Language: Английский

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Biotemplated fabrication of N/O co-doped porous carbon confined spinel NiFe2O4 heterostructured mimetics for triple-mode sensing of antioxidants and ameliorating packaging properties

Food Chemistry, Journal Year: 2024, Volume and Issue: 441, P. 138365 - 138365

Published: Jan. 7, 2024

Language: Английский

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Recent advances on biomedical applications of zirconium-based Nanozymes: A review

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159464 - 159464

Published: Jan. 1, 2025

Language: Английский

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A “three-in-one” detection platform based on cerium-coated metal-organic framework for multimodal glyphosate detection

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137632 - 137632

Published: Feb. 16, 2025

Language: Английский

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