Emission dynamics of reactive oxygen species and oxidative potential in particles from a petrol car and wood stove DOI Creative Commons
Battist Utinger, Alexandre Barth, Andreas Paul

et al.

Aerosol Research, Journal Year: 2025, Volume and Issue: 3(1), P. 205 - 218

Published: April 22, 2025

Abstract. Air pollution is one of the largest environmental health risks and leading causes adverse outcomes mortality worldwide. The possible importance oxidative potential (OP) as a metric to quantify particle toxicity in air increasingly being recognised. In this work, OP reactive oxygen species (ROS) activity particles from fresh aged petrol passenger car emissions residential wood combustion (RWC) were investigated using two novel instruments. Applying online instruments an ascorbic acid (AA) 2′,7′-dichlorodihydrofluorescein (DCFH) assay provides much higher temporal resolution compared with traditional filter-based methods allows for new insights into highly dynamic changes ROS these sources. Due efficiency particulate filter Euro 6d car, almost no primary emitted and, thus, or was detected exhaust. However, substantial ROSs observed after photochemical ageing due formation secondary particles. Increasing also when comparing RWC emissions. Overall, had signals This suggests that could be major contributor may intrinsically more harmful emission source than exhaust, although still high. These measurements illustrate strong differences nature toxicity-relevant properties sources contribute efficient mitigation policies.

Language: Английский

Health effects of carbonaceous PM2.5 compounds from residential fuel combustion and road transport in Europe DOI Creative Commons
Niki Paisi, Jonilda Kushta, Andrea Pozzer

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 17, 2024

Abstract Exposure to fine particulate matter (PM2.5) is associated with an increased risk of morbidity and mortality. In Europe, residential fuel combustion road transport emissions contribute significantly PM2.5. Toxicological studies indicate that PM2.5 from these sources relatively more hazardous, owing its high content black organic carbon. Here, we study the contribution sectors long-term exposure excess mortality in Europe. We quantified impact anthropogenic carbonaceous aerosols on performed a sensitivity analysis assuming they are twice as toxic inorganic particles. find total leads 72,000 (95% confidence interval: 48,000–99,000) deaths per year, about 40% attributed aerosols. Similarly, 35,000 (CI 23,000–47,000) 6000 4000–9000) due Assuming other components, 80% 37%, respectively, transport-related deaths. uncover robust national variations each sector emphasize importance country-specific emission reduction policies based characteristics sectoral shares.

Language: Английский

Citations

9
PM2.5-induced ferroptosis by Nrf2/Hmox1 signaling pathway led to inflammation in microglia DOI
Haiyun Wei, Chao Chen,

Fanglin Di

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 352, P. 124130 - 124130

Published: May 8, 2024

Language: Английский

Citations

9
A study on the forecast of fine dust emissions in the future according to the introduction of eco-friendly ships DOI

Jungwook Lee,

Jia‐Rong Chen, Tsz Leung Yip

et al.

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 212, P. 117507 - 117507

Published: Jan. 6, 2025

Language: Английский

Citations

1
An interlaboratory comparison to quantify oxidative potential measurement in aerosol particles: challenges and recommendations for harmonisation DOI Creative Commons
Pamela Dominutti, Jeań-Luc Jaffrezo, Anouk Marsal

et al.

Atmospheric measurement techniques, Journal Year: 2025, Volume and Issue: 18(1), P. 177 - 195

Published: Jan. 13, 2025

Abstract. This paper presents the findings from a collaborative interlaboratory comparison exercise designed to assess oxidative potential (OP) measurements conducted by 20 laboratories worldwide. study represents an innovative effort as first specifically aimed at harmonising this type of OP assay, setting new benchmark in field. Over last decade, there has been noticeable increase studies, with numerous research groups investigating effects exposure air pollution particles through evaluation levels. However, absence standardised methods for resulted variability results across different groups, rendering meaningful comparisons challenging. To address issue, engages international compare using simplified method (with dithiothreitol (DTT) assay). Here, we quantify liquid samples focus on protocol measurement itself, while future (ILCs) should aim whole chain process, including sample extraction. We analyse similarities and discrepancies observed results, identifying critical parameters (such instrument used, use protocol, delivery analysis time) that could influence provide recommendations studies even if other crucial aspects, such sampling PM methods, storage, extraction conditions, assays, still need be standardised. approach enhances robustness DTT assay paves way build unified framework. pioneering work concludes essential insights into metric are move toward harmonisation measurements.

Language: Английский

Citations

1
Assessment of oxidative stress induced by atmospheric particulate matter: from acellular and cellular assays to the use of model and experimental organisms DOI Creative Commons
Emanuele Vaccarella, Lorenzo Massimi, Silvia Canepari

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 965, P. 178651 - 178651

Published: Jan. 31, 2025

Oxidative stress is considered one of the major mechanisms by which atmospheric particulate matter (PM) can induce adverse effects on living systems. Recently, assessment PM-induced oxidative has gained importance, and many efforts have been invested in identifying most suitable techniques for evaluating PM toxicological potential. This paper briefly resumes current knowledge criticisms related to application OP cellular assays systematically reviews studies focused using model or experimental organisms. Currently, widely used are acellular potential (OP) assays, allow a quick relatively low-cost PM; however, their biological representativeness still be confirmed. Other popular based exposure different cell lines, allows assessing outcomes; they simple systems unable properly represent response complexity complete organism. Another issue both that mainly applied extracts sampled filters, with possible alteration actual oxidizing properties sample. Conversely, use organisms less frequent literature, even though this would enable evaluation multiple pathways and, some cases, prevention any physicochemical situ exposure. In review, we analyzed available papers study induced plant lower animal model/experimental our opinion, increased employment may overcome shown conventional methods.

Language: Английский

Citations

1
High-resolution spatio-temporal estimation of street-level air pollution using mobile monitoring and machine learning DOI
Long Qi, Jun Ma, Cui Guo

et al.

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 377, P. 124642 - 124642

Published: Feb. 22, 2025

Language: Английский

Citations

1
Oxidative stress and inflammation induced by air pollution-derived PM2.5 persist in the lungs of mice after cessation of their sub-chronic exposure DOI Creative Commons
E. Barbier, J. Carpentier, O. Simonin

et al.

Environment International, Journal Year: 2023, Volume and Issue: 181, P. 108248 - 108248

Published: Oct. 12, 2023

More than 7 million early deaths/year are attributable to air pollution. Current health concerns especially focused on pollution-derived particulate matter (PM). Although oxidative stress-induced airway inflammation is one of the main adverse outcome pathways triggered by PM, persistence both these underlying mechanisms, even after exposure cessation, remained poorly studied. In this study, A/JOlaHsd mice were also exposed acutely (24 h) or sub-chronically (4 weeks), with without a recovery period (12 two urban PM2.5 samples collected during contrasting seasons (i.e., autumn/winter, AW spring/summer, SS). The distinct intrinsic potentials (OPs) and SS PM2.5, as evaluated in acellular conditions, closely related their respective physicochemical characteristics ability really generate ROS over-production mouse lungs. Despite activation nuclear factor erythroid 2-related 2 (Nrf2) cell signaling pathway and, lesser degree, murine lungs acute sub-chronic exposures, critical redox homeostasis was not restored, cessation. Accordingly, an inflammatory response reported through factor-kappa B (NF-κB) activation, secretion cytokines, recruitment cells, exposures extent, which persisted period. Taken together, original results provided, for first time, new relevant insights that relatively high OPs, induced stress inflammation, admittedly at lower level thereby contributing occurrence molecular cellular events leading development and/or exacerbation future chronic lung diseases cancers.

Language: Английский

Citations

19
Long-term PM1 exposure and hypertension hospitalization: A causal inference study on a large community-based cohort in South China DOI
Yuqin Zhang, Shirui Chen, Jing Wei

et al.

Science Bulletin, Journal Year: 2024, Volume and Issue: 69(9), P. 1313 - 1322

Published: March 16, 2024

Language: Английский

Citations

8
Sensitivity of PM10 oxidative potential to aerosol chemical composition at a Mediterranean urban site: ascorbic acid versus dithiothreitol measurements DOI Creative Commons
Álvaro Clemente,

Juan Gil-Moltó,

Eduardo Yubero

et al.

Air Quality Atmosphere & Health, Journal Year: 2023, Volume and Issue: 16(6), P. 1165 - 1172

Published: March 13, 2023

The oxidative potential (OP) of PM10 daily samples collected at a traffic site in southeastern Spain during summer and winter was assessed by two acellular assays: the ascorbic acid (AA) dithiothreitol (DTT) methods. Although levels were similar both periods, OP values (expressed nmol min-1 m-3) showed defined seasonal trend. AA activity higher than winter, whereas DTT reactivity exhibited an opposite pattern. Both assays sensitive to different components, as shown results linear correlation analysis. Moreover, relationship between chemical species not same indicating that particle toxicity is associated with sources warm cold seasons. When expressed on mass basis (nmol µg-1), lower coefficients generally obtained compared volume-normalized activities. These outcomes suggest only some specific components have significant intrinsic potential.The online version contains supplementary material available 10.1007/s11869-023-01332-1.

Language: Английский

Citations

16
Rapid transformation of wildfire emissions to harmful background aerosol DOI Creative Commons
Christina N. Vasilakopoulou, Angeliki Matrali, Ksakousti Skyllakou

et al.

npj Climate and Atmospheric Science, Journal Year: 2023, Volume and Issue: 6(1)

Published: Dec. 21, 2023

Abstract Wildfires are a significant source of organic aerosol during summer, with major impacts on air quality and climate. However, studies in Europe suggest surprisingly low (less than 10%) contribution biomass burning to average summertime fine particulate matter levels. In this study we combine field measurements atmospheric chemical transport modeling, demonstrate that the wildfires particle levels summer is seriously underestimated. Our work suggests corresponding has been underestimated by factor 4–7 were responsible for approximately half total OA July 2022. This discrepancy previous due rapid physicochemical transformation these emissions secondary oxidized an accompanying loss its fingerprints. These reactions lead regionally distributed background fraction health-related caused particles probably other continents. adverse health effects can occur hundreds or even thousands kilometers away from fires. We estimate wildfire 15–22% deaths exposure summer.

Language: Английский

Citations

16