The untold story of PFAS alternatives: Insights into the occurrence, ecotoxicological impacts, and removal strategies in the aquatic environment

Water Research, Journal Year: 2023, Volume and Issue: 250, P. 121044 - 121044

Published: Dec. 23, 2023

Language: Английский

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Evidence of promoting effects of 6:2 Cl-PFESA on hepatocellular carcinoma proliferation in humans: An ideal alternative for PFOS in terms of environmental health?

Environment International, Journal Year: 2024, Volume and Issue: 186, P. 108582 - 108582

Published: March 16, 2024

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are synthetic chemicals, encompassing compounds like perfluorooctane sulfonate (PFOS), which have widespread applications across various industries, including food packaging firefighting. In recent years, China has increasingly employed 6:2 Cl-PFESA as an alternative to PFOS. Although the association between PFAS exposure hepatocellular carcinoma (HCC) been demonstrated, underlying mechanisms that promote HCC proliferation uncleared. Therefore, we aimed investigate effects differences of PFOS on through in vivo vitro tumor models. Our results reveal both significantly contribute vivo. Exposure led reduced population doubling times, enlarged cell colony sizes, enhanced DNA synthesis efficiency, a higher proportion cells undergoing mitosis. Furthermore, Cl-PFES) shown activate PI3K/AKT/mTOR signaling pathway inhibit necroptosis. This action consequently enhances cells. phenotypic assay findings suggest tumorigenic potential surpasses PFOS; subcutaneous model using nude mice, mean weight for Cl-PFESA-treated cohort was 2.33 times observed (p < 0.01). Despite being considered safer substitute PFOS, pronounced this chemical growth warrant thorough assessment hepatotoxicity risks linked its usage.

Language: Английский

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Per- and polyfluoroalkyl substances induce lipid metabolic impairment in fish: Integration on field investigation and laboratory study

Environment International, Journal Year: 2024, Volume and Issue: 187, P. 108687 - 108687

Published: April 23, 2024

The biotoxicity of perfluoroalkyl and polyfluoroalkyl substances (PFASs) to aquatic organisms has been widely concerned. However, studies on toxic effects PFASs are usually evaluated directly by using laboratory exposure rather than validation based data obtained in the field. In this study, wild catfish (Silurus meridinalis) was explored relationship between bioaccumulation lipid disorders. Nine thirteen metabolites were significantly associated with perfluorooctane sulfonate (PFOS) 6:2/8:2Cl-PFESA (trade name F-53B) exposures, respectively; correlated fatty acid (FA) conjugates, FA esters, steroids, glycerophosphate subclasses. metabolism fish its mechanism further analyzed through experiments. Zebrafish (Danio rerio) different sexes underwent PFOS F-53B exposures for 21 days at 100 ng/L μg/L. By determining gene expression levels, hepatic contents, histopathological change, adverse order male or female μg/L/F-53(−|-)B > μg/L ng/L/F-53(−|-)B PFOS; stress response more intensive that female. activated peroxisome proliferator-activated receptor pathway, promoting processes total cholesterol (T-CHO) transport, β-oxidation, synthesis, finally induced T-CHO transportation from blood into liver, then accelerated ester transformation, CHO steroids. Laboratory experiments confirmed field analysis. This study innovatively their mechanisms highlighting concerns regarding health risks.

Language: Английский

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Early life exposure to F-53B induces neurobehavioral changes in developing children and disturbs dopamine-dependent synaptic signaling in weaning mice

Environment International, Journal Year: 2023, Volume and Issue: 181, P. 108272 - 108272

Published: Oct. 17, 2023

Previous studies have shown that F-53B exposure may be neurotoxic to animals, but there is a lack of epidemiological evidence, and its mechanism needs further investigation. Serum concentrations Wisconsin Card Sorting Test (WCST) were evaluated in 314 growing children from Guangzhou, China, the association between them analyzed. To study developmental neurotoxicity F-53B, experiments on sucking mice exposed via placental transfer breast milk was performed. Maternal orally 4, 40, 400 μg/L postnatal day 0 (GD0) 21 (PND 21). Several genes proteins related neurodevelopment, dopamine anabolism, synaptic plasticity examined by qPCR western blot, respectively, while contents detected ELISA kit weaning mice. The result showed positively associated with poor WCST performance. For example, an interquartile range increase change 95% confidence interval (CI) correct response (CR), non-perseverative errors (NPE) -2.47 (95% CI: -3.89, -1.05, P=0.001), 2.78 0.79, 4.76, P=0.007), respectively. Compared control group, highest group had longer escape latency (35.24s vs. 51.18s, P=0.034) lesser distance movement (34.81% 21.02%, P<0.001) target quadrant, as observed morris water maze (MWM) test. protein expression brain-derived neurotrophic factor (BDNF) growth protein-43 (GAP-43) levels decreased, compared (0.367-fold, P<0.001; 0.366-fold, respectively). We also upregulation transporter (DAT) (2.940-fold, consistent trend content (1.313-fold, hippocampus. Early life adverse neurobehavioral changes developing which modulated dopamine-dependent plasticity.

Language: Английский

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Study on Aqueous Film Forming Foam Extinguishing Agents Based on Perfluorobranched Short-Chain Fluorocarbon–Hydrocarbon Surfactant Complex Mixtures

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Aqueous film-forming foam (AFFF) is a targeted product for liquid fuel fires and has the benefits of long storage period high fire extinguishing efficiency. However, because toxicity bioaccumulation core raw material's long-chain fluorocarbon surfactant, traditional AFFF being phased out. For this reason, three efficient AFFFs (F-1, F-2, F-3; more details in Table 2) were designed using anionic surfactants (PBAF) with branched C6 perfluorinated chains, hexadecyltrimethylammonium bromide (CTAB), dodecyl dimethyl betaine (BS-12) as materials. Through comparison, F-1 shows excellent foaming ability (initial height 86 mm) stability (25% drainage time 234 s). Moreover, exhibited resistance performance: was 33 s, 831 s. This means that enormous firefighting potential can serve alternative to AFFF.

Language: Английский

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Neurobehavioral Response in Zebrafish Exposed to Perfluorooctane Sulfonate and its Substitutes: Underestimated Ecological Risks

Published: Jan. 1, 2025

Language: Английский

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PFOS and Its Substitute OBS Cause Endothelial Dysfunction to Promote Atherogenesis in ApoE^–/– Mice

Environment & Health, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Perfluorooctanesulfonate (PFOS), an emerging contaminant with widespread concern, has been associated the pathogenesis of atherosclerosis (AS). As a substitute for PFOS, sodium p-perfluorous nonenoxybenzenesulfonate (OBS) is extensively utilized in various applications and detected human blood. However, its potential health risk AS remain unclear. In this study, we investigated comparative impacts PFOS OBS on endothelial dysfunction atherogenesis. vivo Apolipoprotein E knockout (ApoE–/–) mice were exposed to 0.4 or 4 mg/L PFOS/OBS 12 weeks. We found that dyslipidemia developed more rapidly OBS-exposed than PFOS-exposed mice. exhibited higher enrichment capacity both blood aortic tissues OBS. Remarkably, induced pronounced inflammatory response caused significant disruption barrier aorta ApoE–/– compared PFOS. vitro experiments showed OBS, at same exposure concentrations durations as (0.1–20 μmol/L, 48 h), effectively inhibited cell viability umbilical vein cells (HUVECs), levels lactate dehydrogenase (LDH) release, enhanced adhesion between HUVECs monocytes. Both activate NF-κB signaling pathway upregulate expression factors. Notably, use but not was shown disrupt junctions increase permeability by activating MAPK/ERK pathway. Our findings suggest may lead have greater impact presenting risks cardiovascular diseases.

Language: Английский

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Serum metabolomic analysis in mice exposed to perfluorooctanoic acid and sodium p-perfluorous nonenoxybenzene sulfonate

Molecular & Cellular Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Language: Английский

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Exposure to Sodium p-Perfluorous Nonenoxybenzenesulfonate Induces Renal Fibrosis in Mice by Disrupting Lysine Metabolism

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Environmental exposure is one driving factor of chronic kidney disease (CKD), yet the intrinsic molecular mechanisms are largely unexplored. As a persistent chemical, perfluorooctanesulfonate (PFOS) regulated due to great potential induce multiple diseases, including renal fibrosis, major pathological characteristic CKD. It hypothesized that sodium p-perfluorous nonenoxybenzenesulfonate (OBS), typical alternative PFOS, may also fibrosis. We observed distinct fibrosis in mice exposed OBS. Metabolomics analysis showed Nα-acetyllysine was primary metabolite biomarker, whose level decreased greatly its excessive consumption by lysyloxidase (LOX). This suppressed miR-140-5p expression, promoting upregulation fibroblast growth 9 (FGF9), which activated PI3K/Akt signaling pathway through receptor 3 (FGFR3), thereby enhancing proliferation and activation fibroblasts. Supplement upregulated reduced expressions FGF9 FGFR3, eventually ameliorated OBS-induced Similarly, treatment with agomir inhibitor LY294002 attenuated Taken together, OBS caused LOX-Nα-acetyllysine-miR-140-5p-FGF9-FGFR3-PI3K/Akt-Bad-Bcl-2-fibroblast axis. The results this study reveal specific axis for call concerns supervising application

Language: Английский

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Multiomic Landscape of Primary Hypothyroidism Induced by Subchronic Exposure to Low-Dose Novel PFOS Substitute OBS in Human and Murine Models

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Sodium p-perfluorous nonenoxybenzenesulfonate (OBS) as a novel surrogate for perfluorooctanesulfonate (PFOS) has been extensively utilized in industrial manufacturing and daily life. However, studies on OBS-induced environmental health risks of obstructive biosynthesis are currently limited, particularly the risk thyroid diseases. Following construction vivo (mouse) vitro (normal human primary thyrocytes) models subchronic low-dose OBS exposure, we explored thyroid-disrupting effects through multiomics approaches experimental validations. Our results showed that exposure to low doses led hypothyroidism mice, presenting with reduced number functional abnormalities thyrocytes. Further assays confirmed disulfidptosis, newly discovered form programmed cell death, Meanwhile, remarkably suppressed hormone synthesis pathways mouse The charted multiomic landscape mammals revealed toxicity endocrine-disrupting properties OBS, suggesting it is not safe alternative PFOS.

Language: Английский

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