Analytical Methods, Journal Year: 2023, Volume and Issue: 15(42), P. 5639 - 5654

Published: Jan. 1, 2023

In this work, the crystal plane of strontium oxide (SrO) nanorods was integrated into hexagonal-boron nitride (h-BN) nanosheets to form 1D-2D (SrO/h-BN) composite were utilized for electrochemical detection chemotherapeutic drug 5-fluorouracil (5-Fu). 5-Fu is a clinically proven and third most frequently applied treating solid tumours, such as colorectal, stomach, cutaneous breast malignancies. Its overdoses lead toxic metabolite accumulation that has serious adverse consequences on humans, including neurotoxicity, death induction morbidity. Therefore, improve chemotherapy predict potential effects residues in human body, susceptible quick analytical methods detecting body fluids (blood serum/plasma urine) are needed. The effective interaction synthesized SrO/h-BN shows increased efficiency with good selectivity. Notably, simple sonochemical method achieved synergistic between (100) SrO (002) h-BN. Various spectroscopic techniques used characterize nanocomposite, which provided useful insights composition properties material. crystalline, structural chemical characteristics as-synthesized material characterized by XRD, Raman spectroscopy, HR-TEM, XPS HR-SEM. Furthermore, proposed electrode's sensing capability analysed using CV, EIS, DPV i-t curve methods. Numerous active sites created modified electrode enhanced mass transport electron transfer rate, thereby increasing activity towards detection. Consequently, under optimized conditions, SrO/h-BN/GCE exhibited remarkable selectivity, durability, low limit (0.003 μM) wide linear range (0.02-56 5-Fu. Finally, successful application sensor biological samples successfully tested high recovery percentages.

Language: Английский