Phthalates Induce Neurotoxicity by Disrupting the Mfn2-PERK Axis-Mediated Endoplasmic Reticulum–Mitochondria Interaction

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(13), P. 7411 - 7422

Published: Feb. 23, 2024

Di-(2-ethylhexyl) phthalate (DEHP), as the most common phthalate, has been extensively used a plasticizer to improve plasticity of agricultural products, which pose severe harm human health. Mitochondrial dynamics and endoplasmic reticulum (ER) homeostasis are indispensable for maintaining mitochondria-associated ER membrane (MAM) integrity. In this study, we aimed explore effect DEHP on nervous system its association with ER-mitochondria interaction. Here, showed that caused morphological changes, motor deficits, cognitive impairments, blood-brain barrier disruption in brain. triggered stress, is mainly mediated by protein kinase R-like (PERK) signaling. Moreover, DEHP-induced mitofusin-2 (Mfn2) downregulation results imbalance mitochondrial dynamics. Interestingly, exposure impaired MAMs inhibiting Mfn2-PERK Above all, study elucidates axis-mediated interaction phthalate-induced neurotoxicity could be potentially developed novel therapy neurological diseases.

Language: Английский

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Quantification of Microplastics and Phthalate Esters in Nasal Lavage Fluid of Hospital Employees after Face Mask Use

Water Air & Soil Pollution, Journal Year: 2025, Volume and Issue: 236(2)

Published: Jan. 23, 2025

Language: Английский

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Freshwater water quality criteria for phthalate esters and recommendations for the revision of the water quality standards

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116517 - 116517

Published: May 27, 2024

With increasing urbanization and rapid industrialization, more environmental problems have arisen. Phthalates (PAEs) are the foremost most widespread plasticizers readily emitted from these manufactured products into environment. PAEs act as endocrine-disrupting chemicals (EDCs) can serious impacts on aquatic organisms well human health. In this study, water quality criteria (WQC) of five (dimethyl phthalate (DMP), diethyl (DEP), dibutyl (DBP), butyl benzyl (BBP) di(2-ethylhexyl) (DEHP)) for freshwater were developed using a species sensitivity distribution (SSD) toxicity percentage ranking (TPR) approach. The results showed that long-term (LWQC) SSD method could be 13.7, 11.1, 2.8, 7.8, 0.53 μg/L, respectively. Criteria continuous concentrations (CCC) derived TPR determined to 28.4, 13.1, 1.3, 2.5, 1.6 commonly measured in China surface waters at between ng/L μg/L. DBP, DEHP, di-n-octyl (DnOP) frequently detected PAEs, with occurrence rates ranging 67% 100%. ecological risk assessment decreasing order national level, DMP, DEP, DnOP. study will great benefit other countries revising standards conservation species.

Language: Английский

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Impacts of climatic stressors on dissolved organic matter leaching from microplastics and their effects on biogeochemical processes: A review

Water Research, Journal Year: 2024, Volume and Issue: 271, P. 122867 - 122867

Published: Nov. 28, 2024

Language: Английский

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The global research trends and hotspots on phthalate esters (PAEs): A comprehensive visualization and bibliometric analysis (2000-2023)

Environmental Chemistry and Ecotoxicology, Journal Year: 2025, Volume and Issue: 7, P. 381 - 393

Published: Jan. 1, 2025

Language: Английский

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Leachate from Weathered Face Masks Increases DNA Damage to Sperm of Sand Dollars Scaphechinus mirabilis

Toxics, Journal Year: 2025, Volume and Issue: 13(5), P. 372 - 372

Published: May 4, 2025

The COVID-19 pandemic has exacerbated the problem of environmental contamination disposable personal protective equipment, in particular face masks (FMs). As a result factors, FMs undergo aging and fragmentation processes become source microplastics (MPs) chemical additives. Taking into account scale accumulation used their fragments coastal zone, it should be expected that most appreciable ecotoxicological consequences observed hydrobionts inhabiting ecosystems. Based on this, aim this study was to investigate toxicity leachates from pristine weathered using sperm sand dollars Scaphechinus mirabilis. In our work, we FMs, which for 200 days were kept external environment under natural conditions exposed complex climatic factors. Fourier transform infrared spectroscopy characterize changes occurred polymer structure during period. It follows results obtained reduced viability; stimulated lipid peroxidation products, such as malondialdehyde (MDA); significantly increased destruction DNA molecules, showing genotoxic effect. Overall, complement limited experimental data presented, indicating properties mask extracts.

Language: Английский

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Toxicity of antimony to Daphnia magna: Influence of environmental factors, development of biotic ligand approach and biochemical response at environmental relevant concentrations

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 462, P. 132738 - 132738

Published: Oct. 7, 2023

Language: Английский

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Kill two birds with one stone: Biochar immobilised polydopamine coated compound bacterial agent for remediation of dibutyl phthalate contaminated soil

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 120872 - 120872

Published: Jan. 1, 2025

Language: Английский

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Chlorination enhances the phthalates release and increases the cytotoxicity and bacterial functions related to human disease of drinking water in plastic pipes

Water Research, Journal Year: 2025, Volume and Issue: unknown, P. 123218 - 123218

Published: Jan. 1, 2025

Language: Английский

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Phthalates in face masks and their effects on cellular energetics in human bronchial epithelial cells

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117910 - 117910

Published: Feb. 21, 2025

Language: Английский

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