Adverse Outcomes Following Exposure to Perfluorooctanesulfonamide (PFOSA) in Larval Zebrafish (Danio rerio): A Neurotoxic and Behavioral Perspective DOI Creative Commons

Nikita David,

Emma Ivantsova, Isaac Filipe Moreira Konig

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(10), P. 723 - 723

Published: Oct. 4, 2024

Toxicity mechanisms of per- and polyfluoroalkyl substances (PFASs), a chemical class present in diverse ecosystems, as well many their precursors, have been increasingly characterized aquatic species. Perfluorooctanesulfonamide (PFOSA, C8H2F17NO2S) is common precursor perfluorooctane sulfonic acid (PFOS), long-chain PFAS. Here, we assessed sub-lethal endpoints related to development, oxidative stress, transcript levels, distance moved zebrafish embryos larvae following continuous exposure PFOSA beginning at 6 h post-fertilization (hpf). decreased survival fish treated with 1 µg/L PFOSA; however, the effect was modest relative controls (difference 10%). Exposure up 10 did not affect hatch rate, nor it induce ROS 7-day-old fish. The activity larval 100 reduced solvent control. Transcripts stress response apoptosis were measured BCL2-associated X, regulator (bax), cytochrome c, somatic (cycs), catalase (cat), superoxide dismutase 2 (sod2) induced high concentrations PFOSA. Genes neurotoxicity also levels acetylcholinesterase (ache), elav-like RNA binding protein 3 (elavl3), growth-associated 43 (gap43), synapsin II (syn2a), tubulin (tubb3) all increased higher exposure. These data improve our understanding potential toxicity

Language: Английский

Degradation differences in N-ethylperfluorooctane sulfonamidoacetic acid by vacuum ultraviolet (VUV)/peroxydisulfate and VUV/sulfite: Kinetics, products, and mechanism DOI
Hong Liu, Ruibao Jia,

Xiaodong Xin

et al.

Journal of Water Process Engineering, Journal Year: 2024, Volume and Issue: 61, P. 105237 - 105237

Published: April 11, 2024

Language: Английский

Citations

4
Rethink Biosolids: Risks and Opportunities in the Circular Economy DOI
Jinkai Xue, Jinyong Liu, Feng Xiao

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Single-cell RNA sequencing reveals tissue-specific transcriptomic changes induced by perfluorooctanesulfonic acid (PFOS) in larval zebrafish (Danio rerio) DOI

Kruuttika M. Satbhai,

Emily Marques, Ravi Ranjan

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137515 - 137515

Published: Feb. 6, 2025

Language: Английский

Citations

0
PFOS and Its Substitute OBS Cause Endothelial Dysfunction to Promote Atherogenesis in ApoE–/– Mice DOI Creative Commons
Boxiang Zhang, Qing Li, Wensheng Wang

et al.

Environment & Health, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Perfluorooctanesulfonate (PFOS), an emerging contaminant with widespread concern, has been associated the pathogenesis of atherosclerosis (AS). As a substitute for PFOS, sodium p-perfluorous nonenoxybenzenesulfonate (OBS) is extensively utilized in various applications and detected human blood. However, its potential health risk AS remain unclear. In this study, we investigated comparative impacts PFOS OBS on endothelial dysfunction atherogenesis. vivo Apolipoprotein E knockout (ApoE–/–) mice were exposed to 0.4 or 4 mg/L PFOS/OBS 12 weeks. We found that dyslipidemia developed more rapidly OBS-exposed than PFOS-exposed mice. exhibited higher enrichment capacity both blood aortic tissues OBS. Remarkably, induced pronounced inflammatory response caused significant disruption barrier aorta ApoE–/– compared PFOS. vitro experiments showed OBS, at same exposure concentrations durations as (0.1–20 μmol/L, 48 h), effectively inhibited cell viability umbilical vein cells (HUVECs), levels lactate dehydrogenase (LDH) release, enhanced adhesion between HUVECs monocytes. Both activate NF-κB signaling pathway upregulate expression factors. Notably, use but not was shown disrupt junctions increase permeability by activating MAPK/ERK pathway. Our findings suggest may lead have greater impact presenting risks cardiovascular diseases.

Language: Английский

Citations

0
Hepatotoxicity in Carp (Carassius auratus) Exposed to Perfluorooctane Sulfonate (PFOS): Integrative Histopathology and Transcriptomics Analysis DOI Creative Commons
Lin Tang,

Guijie Hao,

Dongren Zhou

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(4), P. 610 - 610

Published: Feb. 19, 2025

Perfluorooctane sulfonate (PFOS) contamination poses a significant environmental threat due to its widespread distribution and persistence. However, the hepatotoxic effects of PFOS on key aquatic species, such as crucian carp, remain understudied. This study systematically investigated hepatotoxicity underlying molecular mechanisms associated with exposure in carp over 21 day period. We determined 96 h 50% lethal concentration (LC50) 23.17 mg/L. Histopathological transcriptomic analyses confirmed PFOS-induced liver damage characterized by venous congestion, nucleolar dissolution cellular vacuolation. Transcriptomic profiling further identified 1036 differentially expressed genes (DEGs), involving critical pathways related lipid energy metabolism, immunity, endocrine regulation. These are integral development nonalcoholic fatty disease (NAFLD). Specifically, DEGs metabolism showed changes, while those involved indicated disrupted ATP production mitochondrial function. Genes immune response revealed an upregulation pro-inflammatory markers, hormone regulation highlighted alterations signaling. Our findings emphasized that exhibits acute toxicity potentially inducing disrupting multiple physiological systems. research provides theoretical foundation for mitigating pollution protecting eco-health, contributing broader ecological conservation biology discussions.

Language: Английский

Citations

0
Rethink biosolids: Risks and opportunities in the circular economy DOI Creative Commons
Jinkai Xue, Willy Verstraete, Bing‐Jie Ni

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161749 - 161749

Published: March 1, 2025

Language: Английский

Citations

0
Perfluorobutane Sulfonate (PFOS) Accumulation in Tissues of Cherax quadricarinatus and Its Toxicity Mechanism DOI Creative Commons

Shuang Hong,

Tian Zhu, Chengbin Liu

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 269 - 269

Published: April 1, 2025

Perfluoroctane sulfonate (PFOS) is an emerging pollutant widely existing in aquatic environments that has attracted many scholars’ attention. Cherax quadricarinatus (C. quadricarinatus) are crustaceans live freshwater environments. This study aimed to investigate the long-term toxic exposure effect of PFOS on C. quadricarinatus. Three environment concentrations (1 ng/L, 100 and 10 μg/L) were set for 28 days The results indicated was detected serum, muscle, hepatopancreas quadricarinatus, order accumulation levels as follows: > serum muscle. Furthermore, transcriptomics showed function differentially expressed genes (DEGs) groups related biological processes, metabolism, organic system, immune response. Kyoto Encyclopedia Genes Genomes enrichment analysis DEGs significantly enriched lysosome signaling pathway, retinol binding, fructose mannose glutathione etc., pathway most significant, which key effects

Language: Английский

Citations

0
Contrasting adsorption behavior of perfluorooctane sulfonic acid and its precursor perfluorooctane sulfonamide characterized by bench-scale-corroborated density-functional-theory analysis DOI
Yue Zhang, Jingrui Li, Ni Yan

et al.

Journal of Hydrology, Journal Year: 2025, Volume and Issue: unknown, P. 133274 - 133274

Published: April 1, 2025

Language: Английский

Citations

0
Perfluorohexanesulfonic Acid (PFHxS) Induces Hepatotoxicity through the PPAR Signaling Pathway in Larval Zebrafish (Danio rerio) DOI

Haolin Liao,

Ying‐Jie He, Shuwen Zhang

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

In recent years, the industrial substitution of long-chain per- and polyfluoroalkyl substances (PFAS) with short-chain alternatives has become increasingly prevalent, resulting in widespread environmental detection perfluorohexanesulfonic acid (PFHxS), a PFAS. However, there remains limited information about potential adverse effects PFHxS at concentrations to wildlife. Here, early life stage zebrafish (

Language: Английский

Citations

3
In vitro screening of understudied PFAS with a focus on lipid metabolism disruption DOI Creative Commons
Lackson Kashobwe,

Faezeh Sadrabadi,

Albert Braeuning

et al.

Archives of Toxicology, Journal Year: 2024, Volume and Issue: 98(10), P. 3381 - 3395

Published: July 2, 2024

Abstract Per- and polyfluoroalkyl substances (PFAS) are man-made chemicals used in many industrial applications. Exposure to PFAS is associated with several health risks, including a decrease infant birth weight, hepatoxicity, disruption of lipid metabolism, decreased immune response. We the vitro cell models screen six less studied [perfluorooctane sulfonamide (PFOSA), perfluoropentanoic acid (PFPeA), perfluoropropionic (PFPrA), 6:2 fluorotelomer alcohol (6:2 FTOH), sulfonic FTSA), 8:2 (8:2 FTSA)] for their capacity activate nuclear receptors cause differential expression genes involved metabolism. Cytotoxicity assays were run parallel exclude that observed gene was due cytotoxicity. Based on cytotoxicity studies, PFOSA shown be more potent than other tested PFAS. crucial bile synthesis detoxification, cholesterol synthesis, transport, metabolism regulation. Except FTOH FTSA, all downregulated PPARA expression. The reporter assay also showed FTSA transactivated farnesoid X receptor (FXR). this study, PFOSA, prioritized further studies confirm understand possible effects hepatic

Language: Английский

Citations

2