Journal of Xenobiotics,
Journal Year:
2024,
Volume and Issue:
15(1), P. 5 - 5
Published: Dec. 31, 2024
Ibuprofen
(IBP)
is
one
of
the
most
consumed
drugs
in
world.
It
only
partially
removed
wastewater
treatment
plants
(WWTPs),
being
present
effluent
and
sewage
sludge,
causing
widespread
introduction
IBP
as
an
emergent
xenobiotic
different
environmental
compartments.
This
study
describes
use
Labrys
neptuniae
CSW11,
recently
described
degrader,
through
bioaugmentation
processes
for
removal
from
water
under
conditions
(additional
carbon
sources,
various
concentrations
glucose
IBP).
L.
CSW11
showed
very
good
results
a
wide
range
concentrations,
with
100%
4
days
1
5
mg
L-1
7
10
L-1,
up
to
48.4%
28
100
when
using
3
g
additional
source.
Three
metabolites
were
identified
during
biotransformation
process:
1-hydroxyibuprofen
(1-OH-IBP),
2-hydroxyibuprofen
(2-OH-IBP),
carboxyibuprofen
(CBX-IBP),
whose
declined
drastically
presence
glucose.
maintained
certain
degree
toxicity
solution,
even
was
completely
removed.
The
indicate
that
can
be
quite
effective
degrading
water,
but
method
should
improved
consortia
other
bacterial
strains
able
degrade
toxic
produced.
A
genome-based
analysis
revealed
enzymes
could
involved
biodegradation,
potential
metabolic
pathway
proposed
based
on
observed
genome
analysis.
Journal of Fungi,
Journal Year:
2025,
Volume and Issue:
11(1), P. 67 - 67
Published: Jan. 16, 2025
A
significant
concentration
of
pharmaceuticals
has
been
detected
within
composted
sewage
sludge.
Their
uncomplete
removal
and
lack
monitoring
during
composting
neglects
their
potentially
toxic
effects
when
used
as
a
soil
organic
amendment.
Previously,
we
successfully
implemented
bioaugmentation–composting
system
focused
on
toxicity
pharmaceuticals’
reduction.
This
method,
however,
comprised
long
inoculant-acclimatization
period,
making
it
an
unprofitable
technology.
Hence,
this
work
aimed
to
explore
shorter
yet
effective
process
by
simultaneously
implementing
the
inoculation
native
microbial
consortium
fungus
Penicillium
oxalicum
XD
3.1
in
piles
sludge
olive
prunings.
All
were
subjected
frequent
inoculation,
windrow
turning,
physicochemical
biological
parameters.
Additionally,
both
bioaugmentation
stability
degradation
evaluated
through
different
analysis
rates
calculations.
One
hundred
days
earlier
than
previous
attempts,
treatments
achieved
adequate
conditions,
maintained
core
populations
while
improving
degrading
diversity,
around
70–72%
pharmaceutical
remotion.
Nevertheless,
only
produced
favorable
results
ideal
for
amendments
(acute
microtoxicity
phytotoxicity).
Thus,
but
equally
stable
with
P.
was
here.
Microbial Biotechnology,
Journal Year:
2025,
Volume and Issue:
18(1)
Published: Jan. 1, 2025
ABSTRACT
The
inadequate
removal
of
pharmaceuticals
and
personal
care
products
(PPCPs)
by
traditional
wastewater
treatment
plants
(WWTPs)
poses
a
significant
environmental
public
health
challenge.
Residual
PPCPs
find
their
way
into
aquatic
ecosystems,
leading
to
bioaccumulation
in
biota,
the
dissemination
antibiotic
resistance
genes
(ARGs),
contamination
both
water
sources
vegetables.
These
persistent
pollutants
can
have
negative
effects
on
human
health,
ranging
from
development
endocrine
disruption.
To
mitigate
these
risks,
there
is
growing
interest
exploiting
microorganisms
enzymes
for
bioremediation
purposes.
By
harnessing
metabolic
capabilities
microbial
communities,
be
efficiently
degraded,
transformed,
or
sequestered
systems.
Additionally,
communities
exhibit
remarkable
adaptability
resilience
diverse
PPCP
contaminants,
further
underscoring
potential
as
sustainable
cost‐effective
solutions
treatment.
This
review
explores
promise
an
approach
addressing
complex
challenges
posed
contamination,
emphasising
its
safeguard
integrity
well‐being.
Environmental Microbiology Reports,
Journal Year:
2024,
Volume and Issue:
16(4)
Published: Aug. 1, 2024
Abstract
Ibuprofen
(IBU)
is
a
significant
contaminant
frequently
found
in
wastewater
treatment
plants
due
to
its
widespread
use
and
limited
removal
during
processes.
This
leads
discharge
into
the
environment,
causing
considerable
environmental
concerns.
The
of
microorganisms
has
recently
been
recognized
as
sustainable
method
for
mitigating
IBU
contamination
wastewater.
In
this
study,
new
bacteria
capable
growing
solid
medium
with
only
carbon
source
removing
from
liquid
were
isolated
samples,
including
soil,
marine,
mine,
olive
mill
Four
bacterial
strains,
namely
Klebsiella
pneumoniae
TIBU2.1,
variicola
LOIBU1.1,
Pseudomonas
aeruginosa
LOIBU1.2,
Mycolicibacterium
aubagnense
HPB1.1,
identified
through
16S
rRNA
gene
sequencing.
These
strains
demonstrated
efficiencies,
ranging
60
100%
within
14
days,
starting
an
initial
concentration
5
mg
per
litre.
have
not
previously
reported
literature
degraders,
making
work
valuable
contribution
further
studies
field
bioremediation
environments
contaminated
by
IBU.
Based
on
results,
most
promising
bacteria,
K.
TIBU2.1
M.
selected
silico
analysis
identify
genes
potentially
involved
biodegradation.
Interestingly,
tests
peak
transformation
product(s)
was
detected
high‐performance
chromatography,
while
it
detected.
emerging
analysed
chromatography–mass
spectrometry,
indicating
presence
possible
conjugates
between
intermediates
proteins
encoded
their
whole‐genome
sequences
aligned
IBU‐degrading
pathway
respective
catabolic
genes.
indicated
that
strain
HPB1.1
possesses
encoding
similar
enzymes
associated
metabolic
pathways
used
reference
both
upper
lower
part
pathway.
Notably,
having
more
candidate
IBU‐catabolic
enzymes,
no
products
detected,
fewer
these
genes,
detection
occurred.
Drug Development Research,
Journal Year:
2025,
Volume and Issue:
86(1)
Published: Feb. 1, 2025
Acne
is
a
skin
disease
that
impacts
9.4%
of
the
world's
population.
Available
treatments
for
managing
acne
include
retinoid-like
drugs,
antibiotics,
corticosteroids,
photo,
and
radiotherapy.
Howevere,
aforementioned
have
certain
limitations
such
as
possibility
developing
cancer
from
tetracycline,
doxycycline,
microbial
resistance
to
deadly
side
effects,
so
forth.
Repurposing
existing
therapeutics
having
excellent
safety
profile
can
be
promising
way
treat
efficiently.
The
repurposed
drugs
phytoceuticals
diverse
classes
demonstrated
effects
in
treating
acne.
These
displayed
antiacne
effectiveness
by
targeting
single
or
multiple
signaling
pathways.
Various
undergoing
clinical
trials
at
different
phases
their
efficacy
Despite
being
very
good,
safe,
less
time-consuming
strategy,
drug
repurposing
(DR)
faces
challenges
lack
regulatory
guidelines,
preservation
intellectual
property,
validation
claimed
therapeutic
indication.
DR
appears
viable
approach
likely
offer
effective
treatment
reasonable
cost
alleviating
