Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 27, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
unseen,
dangerous
organic
compounds
that
can
cause
major
health
disorders.
PFASs
have
been
categorized
as
persistent,
bioaccumulative,
toxic
(PBT).
This
review
provides
knowledge
about
the
present
in
junk
food
packaging
materials,
which
migrate
into
food.
Different
types
of
samples
were
analyzed
using
analytical
methods.
The
most
preferred
method
extraction
is
ultrasonic-assisted
(UAE).
It
summarizes
approaches
PFASs.
results
numerous
studies
show
perfluorooctanoic
acid
often
detected
compound
with
high
concentrations.
European
Food
Safety
Authority
(EFSA)
announced
tolerable
weekly
intake
(TWI)
4.4
ng/kg.
US
Environmental
Protection
Agency
(EPA)
has
limit
for
perfluorobutane
sulfonic
due
to
its
toxicity
level.
These
potential
effects
on
both
people's
biosphere.
PFAS
usage
stop
industries
a
better
future.
Journal of Biological Chemistry,
Journal Year:
2024,
Volume and Issue:
300(3), P. 105734 - 105734
Published: Feb. 7, 2024
Numerous
putative
glycosyltransferases
(GTs)
have
been
identified
using
bioinformatic
approaches.
However,
demonstrating
the
activity
of
these
GTs
remains
a
challenge.
Here,
we
describe
development
rapid
in
vitro
GT-array
screening
platform
for
GTs.
GT-arrays
are
generated
by
cell-free
protein
synthesis
and
binding
microplates
precoated
with
N-terminal
Halo-
or
C-terminal
GST-tagged
GT-encoding
plasmid
DNA
capture
antibody.
These
arrays
then
used
transferase
activities
reactions
monitored
luminescence
GLO
assay.
The
products
formed
can
be
analyzed
directly
from
mass
spectrometry.
Using
this
platform,
total
280
assays
were
performed
to
screen
22
fucosyltransferases
(FUTs)
family
GT37
(seven
Arabidopsis
15
rice)
toward
five
acceptors:
non-fucosylated
tamarind
xyloglucan
(TXyG),
arabinotriose
(Ara
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(22), P. 8886 - 8892
Published: May 21, 2024
Illegal
addition
of
drugs
is
common
but
seriously
threatens
public
health
safety.
Conventional
mass
spectrometry
methods
are
difficult
to
realize
direct
analysis
existing
in
some
complex
matrices
such
as
seawater
or
soil
due
the
ion
suppression
effect
and
contamination
MS
parts
caused
by
nonvolatile
salts.
In
this
work,
a
novel
crystallization
solvent
evaporation
ionization
(CSEI-MS)
method
was
constructed
developed
achieve
rapid
desalting
detection.
CSEI
only
consists
heated
plate
nebulizer
exhibits
excellent
performance,
enabling
six
dissolved
eight
kinds
salt
solutions
(up
200
mmol/L)
three
salty
matrices.
Under
optimized
conditions,
CSEI-MS
presents
high
sensitivity,
accuracy,
linearity,
intraday
interday
precision.
Finally,
applied
quantitative
seawater,
hand
cream,
soil.
Furthermore,
highly
sensitive
detection
demonstrated
remain
even
if
processes
conducted
within
5
s
via
commercial
tools.
Journal of the American Society for Mass Spectrometry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 13, 2025
Amino
acids
are
commonly
used
as
nutritional
fortification
substances
in
functional
foods,
and
their
chiral
configuration
is
an
important
determinant
of
food
function.
Rapid
screening
methods
urgently
needed
analysis
but
limited
by
the
long-time
separation
matrix
interference.
In
this
study,
we
show
a
kinetic
method
coupled
to
thermal-assisted
paper
spray
ionization
mass
spectrometry
for
direct
determination
enantiomeric
excess
(ee)
multiple
d/l-amino
complex
matrixes
without
sample
pretreatment.
3-(2-Naphthyl)-l-alanine
was
selected
new
reference
ligand
achieve
efficient
differentiation
(discrimination
degree
8.7
d/l-phenylalanine
10.2
d/l-tyrosine).
An
additional
thermal-auxiliary
device
developed
facilitate
purity
determination.
The
allowed
rapid
simultaneous
amino
(d/l-phenylalanine
d/l-tyrosine)
within
30
s.
Good
linearities
were
achieved
quantitation
ee
(R2
=
0.9996
phenylalanine
0.9995
tyrosine)
with
unknown
acid
concentrations
ranging
from
10
μM
600
μM.
successfully
applied
capsules
beverages
showed
great
potential
enantiomer-related
safety
nutrition
analysis.
Analytical Science Advances,
Journal Year:
2025,
Volume and Issue:
6(1)
Published: March 22, 2025
ABSTRACT
The
introduction
of
ambient
ionisation
mass
spectrometry
(AIMS)
is
among
the
most
important
developments
in
analytical
chemistry
recent
years.
Enabling
direct
analysis
samples
their
native
state
with
neither
sample
preparation
nor
chromatographic
separation
provides
chemical
characterisation
a
matter
seconds.
Since
its
inception
early
2000s,
field
has
continued
to
expand
and
develop,
pushing
boundaries
finding
utility
across
broad
areas
scientific
research.
This
annual
review
an
overview
key
applications
AIMS
throughout
2024.
novel
ion
sources,
development
existing
techniques
for
enhanced
performance,
diverse
forensic
science,
food
chemistry,
disease
detection
more
highlight
expanding
versatility
widespread
adoption
globe.
Journal of the American Society for Mass Spectrometry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
Paper
spray
mass
spectrometry
(PS-MS)
often
employs
laser
cutting
to
prepare
paper
substrates,
potentially
inducing
localized
thermal
decomposition
of
the
cellulose
backbone.
This
work
investigates
how
pyrolysis
products
and
inherent
background
molecules
within
affect
PS-MS
signal
quality
evaluates
pretreatment
methods
enhance
performance.
Comparative
analyses
laser-cut
razor-cut
using
ultraviolet-visible
spectroscopy
(UV-vis)
showed
significant
differences.
Laser-cut
exhibited
elevated
MS
blank
signals
higher
absorbance
in
200-400
nm
UV
region,
indicating
increased
chemical
abundance
complexity.
Gas
chromatography-mass
(GC-MS)
identified
over
20
residual
compounds
on
absent
samples,
half
which
were
as
known
products.
Washing
substrates
with
methanol,
water,
or
dilute
nitric
acid
significantly
reduced
both
molecules,
water
showing
most
improvement.
Analyses
morphine,
fentanyl,
methamphetamine,
voriconazole,
fluconazole
no
reduction
after
washing,
fentanyl
methamphetamine
exhibiting
a
signal,
regardless
method.
reveals
that
while
from
contribute
noise,
also
play
role.
A
simple
wash
mitigates
issues,
improving
overall
performance
for
range
analytes.