Toxics,
Journal Year:
2024,
Volume and Issue:
12(8), P. 531 - 531
Published: July 23, 2024
Nanoplastics
(NPs)
cause
serious
contamination
of
drinking
water
and
potential
damage
to
human
health.
This
study
aimed
investigate
the
effects
NPs
with
different
particle
sizes
concentrations
on
reproductive
function
male
mice.
In
this
study,
free
exposure
was
used
expose
BALB/C
mice
PS-NPs
(20
nm,
200
1000
nm)
at
0.1
mg/L,
1
5
mg/L
for
4
months.
The
assessed
after
exposure,
fecal
blood
samples
were
collected
macrogenomics
metabolomics.
results
showed
that
resulted
in
reduced
testicular
organ
coefficients,
decreased
sperm
quality,
altered
tissue
structure,
disturbed
sex
hormone
levels,
abnormal
levels
inflammatory
factors
oxidative
stress.
Furthermore,
found
NP
affected
alteration
gut
communities
metabolic
pathways
related
reproduction,
such
as
Clostridium
glutathione
metabolism.
Importantly,
we
an
effect
size
function.
future,
more
attention
should
be
paid
smaller
NPs.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Since
their
inception
in
the
early
1960s,
use
of
nanoscale
materials
has
progressed
leaps
and
bounds,
role
diverse
fields
ranging
from
human
health
to
energy
is
undeniable.
In
this
report,
we
utilize
CAS
Content
Collection,
a
vast
repository
scientific
information
extracted
journals
patent
publications,
identify
emerging
topics
field.
This
involves
understanding
trends,
such
as
growth
certain
over
time,
well
establishing
relationships
among
topics.
We
achieved
by
using
host
strategies
including
quantitative
natural
language
processing
(NLP)
approach
270
subtopics
across
three
major
categories-materials,
applications,
properties-by
surveying
3
million
documents
spanning
two
decades
nanoscience
landscape.
wealth
been
condensed
into
several
conceptual
Trendscape
maps
other
data
visualizations,
providing
metrics
related
identified
concepts,
grouped
hierarchical
classes,
connections
between
them
have
explored.
Our
extensive
analysis
taking
advantage
an
NLP-based
along
with
robust
indexing
provides
valuable
insights
field
that
hope
can
help
inform
drive
future
research
efforts.
series
interconnected
papers,
will
present
our
findings
project,
focus
on
four
applications
materials-drug
delivery,
sensors,
energy,
catalysis-to
provide
more
comprehensive
detailed
picture
nanotechnology
these
fields.
Journal of Applied Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
ABSTRACT
In
the
environment,
nanoplastics
(NPs)
have
been
shown
to
adversely
impact
reproductive
health,
yet
research
on
their
effects
during
early
pregnancy
is
scarce.
This
study
investigated
of
NPs
endometrial
decidualization
in
pregnant
mice
and
fertility.
Female
were
administered
polystyrene
(PS‐NPs)
orally
for
90
days
before
pregnancy.
Our
findings
indicated
that
PS‐NPs
exposure
decreased
live
birth
rate
neonatal
crown‐rump
length.
Decreased
embryo
implantation
sites
uterine
wet
weight
observed
post
exposure.
Histological
examination
revealed
structural
defects
uteri
a
significant
reduction
follicular
count
across
all
stages
PS‐NPs‐treated
groups.
Serum
levels
estradiol
(E
2
)
progesterone
(P)
elevated,
while
follicle‐stimulating
hormone
(FSH)
luteinizing
(LH)
diminished
post‐exposure.
Additionally,
upregulated
expression
marker
HOXA10
decidua.
conclusion,
our
results
suggest
may
disrupt
disruption
likely
due
perturbation
hormonal
balance
within
hypothalamic–pituitary–ovary
including
FSH,
LH,
E
,
P
levels.
These
alterations
arrest
development,
consequently
leading
detrimental
outcomes
compromised
conditions.
provided
new
perspective
understanding
possible
microplastics
female
F1000Research,
Journal Year:
2025,
Volume and Issue:
14, P. 284 - 284
Published: March 12, 2025
The
extensive
use
of
plastic
without
an
effective
management
system
is
linked
to
significant
environmental
pollution
issues.
The
fragmentation
various
types
waste
leads
the
formation
microplastics
(MPs)
and
nanoplastics
(NPs).
NPs,
measuring
less
than
0.1
μm
pose
a
latent
danger
human
food
chain
caused
by
ability
traverse
biological
membranes
MPs,
potentially
leading
chronic
diseases.
widespread
distribution
NPs
across
diverse
matrices
their
subsequent
infiltration
into
feed
chains
precipitates
emerging
health
concerns.
contaminate
production
systems
leach
from
packaging,
infiltrating
organisms
at
trophic
levels.
Seafood,
processed
foods,
drinking
water
serve
as
vectors
for
absorption
accumulation
in
tissues.
pervasive
contamination
pathway
poses
substantial
risks
through
multiple
exposure
routes,
primarily
ingestion.
It
can
lead
cytotoxicity,
inflammation,
genotoxicity,
apoptosis.
This
review
summarizes
implications
that
triggers
diseases
such
inflammatory
bowel
disease
(IBD),
kidney
dysfunction,
liver
disease,
heart
problems,
brain
disorders,
reproductive
issues,
cancer.
Currently,
no
established
method
exists
treat
humans
may
have
already
ingested.
Hence,
it
urgent
mitigate
harmful
effects
development
implementation
innovative,
efficient,
sustainable
decontamination
strategies.
discussion
highlights
several
advanced
remediation
techniques
effectively
reduce
toxicity
systems,
thus
mitigating
associated
risks.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 23, 2025
Abstract
Ovarian
aging
represents
a
significant
risk
factor
for
female
infertility,
primarily
due
to
decline
in
ovarian
reserve
and
diminished
oocyte
quality.
However,
whether
microplastics
(MPs)
exposure
poses
potential
inducing
the
underlying
mechanisms
remain
poorly
understood.
In
this
study,
we
demonstrated
that
MPs
accelerates
aging,
characterized
by
elevated
expression
of
senescence
markers
(p16
p21)
increased
fibrosis.
Mechanistic
analysis
indicated
led
inflammatory
damage
mitochondrial
dysfunction,
which
contribute
reduced
reserve.
Furthermore,
compromised
maturation
competence
embryo
development
triggering
dysfunction
DNA
damage.
Multi-omics
identified
L-arginine
as
crucial
metabolite
protects
oocytes
from
MPs-induced
aging.
Notably,
supplementation
significantly
mitigated
phenotypes
induced
MPs,
evidenced
fibrosis,
damage,
alongside
enhanced
These
findings
provide
theoretical
support
reproductive
protection
against
inform
environmental
assessments.
Frontiers in Bioscience-Landmark,
Journal Year:
2025,
Volume and Issue:
30(4)
Published: March 31, 2025
Male
infertility
represents
a
major
health
concern,
accounting
for
approximately
50%
of
all
cases
in
couples.
This
condition
arises
from
multiple
etiologies,
with
oxidative
stress
gaining
increasing
attention
recent
studies.
During
the
final
stages
sperm
maturation,
majority
cytoplasm
is
discarded,
leaving
diminished
antioxidant
defense
system,
which
makes
them
highly
susceptible
to
detrimental
effects
reactive
oxygen
species
(ROS).
ROS
can
be
generated
both
intrinsic
and
extrinsic
sources.
Intrinsically,
are
primarily
produced
by
mitochondrial
activity,
while
factors
include
alcohol
consumption,
smoking,
circadian
rhythm
disruption,
gut
microbiota
imbalance,
leukocyte
infiltration.
Excessive
production
leads
DNA
damage,
apoptosis,
epigenetic
modifications
sperm,
ultimately
impairing
motility
contributing
infertility.
review
provides
comprehensive
examination
sources
examines
mechanisms
induce
damage.
Furthermore,
it
explores
therapeutic
potential
antioxidants
mitigating
improving
quality.
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: March 5, 2024
Abstract
Background
Mitochondria
produce
adenosine
triphosphate
through
respiratory
activities
to
power
sperm
differentiation
and
motility,
decreased
mitochondrial
activity
can
result
in
poor
motility
asthenospermia.
The
sheath
is
a
component
of
the
mid-piece
flagellum,
dysfunction
reduce
cause
male
infertility.
membrane
occupation
recognition
nexus-motif
protein
2
(MORN2)
testis
enriched
mice,
MORN
motif
was
reported
play
role
regulation
bioelectrical
signal
homeostasis
cardiomyocytes.
Methods
We
generated
Morn2
–/–
mice
using
CRISPR/Cas9
evaluated
potential
functions
MORN2
spermiogenesis
histological
analysis,
fertility
examination,
RT-PCR,
CASA,
immunofluorescence,
TUNEL,
electron
microscopy
energy
metabolism
etc.
Results
were
infertile,
their
showed
severe
defects.
also
had
abnormal
morphology
characterized
by
bent
heads,
aberrant
formation,
lower
potential,
higher
levels
reactive
oxygen
species,
activity.
Conclusions
Our
study
demonstrates
that
essential
for
indicates
formation
regulates