Toxicity to the Male Reproductive System after Exposure to Polystyrene Nanoplastics: A Macrogenomic and Metabolomic Analysis DOI Creative Commons
Xue Zhang,

Yueping Wu,

Xufeng Fu

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(8), P. 531 - 531

Published: July 23, 2024

Nanoplastics (NPs) cause serious contamination of drinking water and potential damage to human health. This study aimed investigate the effects NPs with different particle sizes concentrations on reproductive function male mice. In this study, free exposure was used expose BALB/C mice PS-NPs (20 nm, 200 1000 nm) at 0.1 mg/L, 1 5 mg/L for 4 months. The assessed after exposure, fecal blood samples were collected macrogenomics metabolomics. results showed that resulted in reduced testicular organ coefficients, decreased sperm quality, altered tissue structure, disturbed sex hormone levels, abnormal levels inflammatory factors oxidative stress. Furthermore, found NP affected alteration gut communities metabolic pathways related reproduction, such as Clostridium glutathione metabolism. Importantly, we an effect size function. future, more attention should be paid smaller NPs.

Language: Английский

Nanoscience in Action: Unveiling Emerging Trends in Materials and Applications DOI Creative Commons
Kevin J. Hughes,

Magesh Ganesan,

Rumiana Koynova

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Since their inception in the early 1960s, use of nanoscale materials has progressed leaps and bounds, role diverse fields ranging from human health to energy is undeniable. In this report, we utilize CAS Content Collection, a vast repository scientific information extracted journals patent publications, identify emerging topics field. This involves understanding trends, such as growth certain over time, well establishing relationships among topics. We achieved by using host strategies including quantitative natural language processing (NLP) approach 270 subtopics across three major categories-materials, applications, properties-by surveying 3 million documents spanning two decades nanoscience landscape. wealth been condensed into several conceptual Trendscape maps other data visualizations, providing metrics related identified concepts, grouped hierarchical classes, connections between them have explored. Our extensive analysis taking advantage an NLP-based along with robust indexing provides valuable insights field that hope can help inform drive future research efforts. series interconnected papers, will present our findings project, focus on four applications materials-drug delivery, sensors, energy, catalysis-to provide more comprehensive detailed picture nanotechnology these fields.

Language: Английский

Citations

0
Exposure to Polystyrene Nanoplastics Compromise Ovarian Reserve Function and Endometrial Decidualization in Early Pregnant Mice DOI

Qian‐Feng Qiao,

Liqing Wang,

Qiongjun Xu

et al.

Journal of Applied Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

ABSTRACT In the environment, nanoplastics (NPs) have been shown to adversely impact reproductive health, yet research on their effects during early pregnancy is scarce. This study investigated of NPs endometrial decidualization in pregnant mice and fertility. Female were administered polystyrene (PS‐NPs) orally for 90 days before pregnancy. Our findings indicated that PS‐NPs exposure decreased live birth rate neonatal crown‐rump length. Decreased embryo implantation sites uterine wet weight observed post exposure. Histological examination revealed structural defects uteri a significant reduction follicular count across all stages PS‐NPs‐treated groups. Serum levels estradiol (E 2 ) progesterone (P) elevated, while follicle‐stimulating hormone (FSH) luteinizing (LH) diminished post‐exposure. Additionally, upregulated expression marker HOXA10 decidua. conclusion, our results suggest may disrupt disruption likely due perturbation hormonal balance within hypothalamic–pituitary–ovary including FSH, LH, E , P levels. These alterations arrest development, consequently leading detrimental outcomes compromised conditions. provided new perspective understanding possible microplastics female

Language: Английский

Citations

0
Relationship of prenatal ambient air pollutants exposure with childhood asthma risk and underlying mechanism: Ma’anshan Birth Cohort study DOI

Yumei Zhong,

Yun Zhou,

Lijun Tang

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: 274, P. 121283 - 121283

Published: March 4, 2025

Language: Английский

Citations

0
Assessing toxicological risk of nanoplastics contaminants in food and feed from ingestion pathway to human diseases DOI Creative Commons
Pipin Agnesia,

Yan Erisma Gangga,

Renata Adaranyssa Egistha Putri

et al.

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 284 - 284

Published: March 12, 2025

The extensive use of plastic without an effective management system is linked to significant environmental pollution issues. The fragmentation various types waste leads the formation microplastics (MPs) and nanoplastics (NPs). NPs, measuring less than 0.1 μm pose a latent danger human food chain caused by ability traverse biological membranes MPs, potentially leading chronic diseases. widespread distribution NPs across diverse matrices their subsequent infiltration into feed chains precipitates emerging health concerns. contaminate production systems leach from packaging, infiltrating organisms at trophic levels. Seafood, processed foods, drinking water serve as vectors for absorption accumulation in tissues. pervasive contamination pathway poses substantial risks through multiple exposure routes, primarily ingestion. It can lead cytotoxicity, inflammation, genotoxicity, apoptosis. This review summarizes implications that triggers diseases such inflammatory bowel disease (IBD), kidney dysfunction, liver disease, heart problems, brain disorders, reproductive issues, cancer. Currently, no established method exists treat humans may have already ingested. Hence, it urgent mitigate harmful effects development implementation innovative, efficient, sustainable decontamination strategies. discussion highlights several advanced remediation techniques effectively reduce toxicity systems, thus mitigating associated risks.

Language: Английский

Citations

0
Effects of Polystyrene Microparticles Exposures on Spermatogenic Cell Differentiation and Reproductive Endpoints in Male Mice DOI
Rong Shen, Peng Xia, Yanan Guo

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: 373, P. 126200 - 126200

Published: April 5, 2025

Language: Английский

Citations

0
Recent advances in microplastics research: impacts on mammalian sperm and reproductive health DOI
Na Wang,

Panpan Jin,

Lirong Wang

et al.

Frontiers of Environmental Science & Engineering, Journal Year: 2025, Volume and Issue: 19(6)

Published: April 15, 2025

Language: Английский

Citations

0
Microplastics exposure causes premature ovarian aging via inducing mitochondrial dysfunction DOI
Xing Duan,

Li‐Shu Li,

Wen-Jiao Liu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract Ovarian aging represents a significant risk factor for female infertility, primarily due to decline in ovarian reserve and diminished oocyte quality. However, whether microplastics (MPs) exposure poses potential inducing the underlying mechanisms remain poorly understood. In this study, we demonstrated that MPs accelerates aging, characterized by elevated expression of senescence markers (p16 p21) increased fibrosis. Mechanistic analysis indicated led inflammatory damage mitochondrial dysfunction, which contribute reduced reserve. Furthermore, compromised maturation competence embryo development triggering dysfunction DNA damage. Multi-omics identified L-arginine as crucial metabolite protects oocytes from MPs-induced aging. Notably, supplementation significantly mitigated phenotypes induced MPs, evidenced fibrosis, damage, alongside enhanced These findings provide theoretical support reproductive protection against inform environmental assessments.

Language: Английский

Citations

0
Deciphering the Role of Oxidative Stress in Male Infertility: Insights from Reactive Oxygen Species to Antioxidant Therapeutics DOI Creative Commons

Ye Zhou,

H Q Zhang,

Heguo Yan

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(4)

Published: March 31, 2025

Male infertility represents a major health concern, accounting for approximately 50% of all cases in couples. This condition arises from multiple etiologies, with oxidative stress gaining increasing attention recent studies. During the final stages sperm maturation, majority cytoplasm is discarded, leaving diminished antioxidant defense system, which makes them highly susceptible to detrimental effects reactive oxygen species (ROS). ROS can be generated both intrinsic and extrinsic sources. Intrinsically, are primarily produced by mitochondrial activity, while factors include alcohol consumption, smoking, circadian rhythm disruption, gut microbiota imbalance, leukocyte infiltration. Excessive production leads DNA damage, apoptosis, epigenetic modifications sperm, ultimately impairing motility contributing infertility. review provides comprehensive examination sources examines mechanisms induce damage. Furthermore, it explores therapeutic potential antioxidants mitigating improving quality.

Language: Английский

Citations

0
Microplastic pollution in Costa Rican marine ecosystems: Origins, ecotoxicological impacts, and mitigation strategies DOI Creative Commons

Juan M. Zúñiga Umaña,

Sergio A. Paniagua, Rónald Sánchez Brenes

et al.

Marine Policy, Journal Year: 2025, Volume and Issue: 179, P. 106772 - 106772

Published: May 17, 2025

Language: Английский

Citations

0
MORN2 regulates the morphology and energy metabolism of mitochondria and is required for male fertility in mice DOI Creative Commons
Yining Liu,

Tongtong Li,

Mingze Shi

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 5, 2024

Abstract Background Mitochondria produce adenosine triphosphate through respiratory activities to power sperm differentiation and motility, decreased mitochondrial activity can result in poor motility asthenospermia. The sheath is a component of the mid-piece flagellum, dysfunction reduce cause male infertility. membrane occupation recognition nexus-motif protein 2 (MORN2) testis enriched mice, MORN motif was reported play role regulation bioelectrical signal homeostasis cardiomyocytes. Methods We generated Morn2 –/– mice using CRISPR/Cas9 evaluated potential functions MORN2 spermiogenesis histological analysis, fertility examination, RT-PCR, CASA, immunofluorescence, TUNEL, electron microscopy energy metabolism etc. Results were infertile, their showed severe defects. also had abnormal morphology characterized by bent heads, aberrant formation, lower potential, higher levels reactive oxygen species, activity. Conclusions Our study demonstrates that essential for indicates formation regulates

Language: Английский

Citations

3