Polyethylene nanoparticles at environmentally relevant concentrations enhances neurotoxicity and accumulation of 6-PPD quinone in Caenorhabditis elegans

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170760 - 170760

Published: Feb. 6, 2024

Language: Английский

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Comparison of intestinal toxicity in enhancing intestinal permeability and in causing ROS production of six PPD quinones in Caenorhabditis elegans

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172306 - 172306

Published: April 7, 2024

Language: Английский

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Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134356 - 134356

Published: April 19, 2024

Language: Английский

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Exposure to 6-PPD quinone causes damage on mitochondrial complex I/II associated with lifespan reduction in Caenorhabditis elegans

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 472, P. 134598 - 134598

Published: May 13, 2024

Language: Английский

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Polylactic acid microplastics cause transgenerational reproductive toxicity associated with activation of insulin and hedgehog ligands in C. elegans

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 942, P. 173746 - 173746

Published: June 7, 2024

Language: Английский

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Neurotoxicity and accumulation of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans

Chemosphere, Journal Year: 2024, Volume and Issue: 361, P. 142499 - 142499

Published: May 31, 2024

Language: Английский

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Transgenerational Response of Germline Nuclear Hormone Receptor Genes to Nanoplastics at Predicted Environmental Doses in Caenorhabditis elegans

Toxics, Journal Year: 2024, Volume and Issue: 12(6), P. 420 - 420

Published: June 7, 2024

Transgenerational nanoplastic toxicity could be detected in Caenorhabditis elegans after exposure at the parental generation (P0-G); however, underlying mechanisms remain largely unclear. We aimed to examine role of germline nuclear hormone receptors (NHRs) controlling transgenerational polystyrene nanoparticles (PS-NPs) based on gene expression screening and functional analysis. Among NHR genes, daf-12, nhr-14, nhr-47 expressions were increased nhr-12 was decreased by PS-NPs (1 10 μg/L). alterations these four genes also induced RNAi caused resistance, whereas conferred susceptibility PS-NP toxicity. After exposure, ins-3, daf-28, ins-39 encoding insulin ligands, efn-3 Ephrin ligand, lin-44 Wnt as well their receptor (daf-2, vab-1, and/or mig-1), dysregulated nhr-47, nhr-12. Therefore, alteration certain NHRs mediate induction affecting secreted ligands offspring exposed organisms.

Language: Английский

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Exposure to 6-PPD quinone enhances glycogen accumulation in Caenorhabditis elegans

Environmental Pollution, Journal Year: 2024, Volume and Issue: 359, P. 124600 - 124600

Published: July 22, 2024

Language: Английский

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Exposure to 6-PPD quinone disrupts glucose metabolism associated with lifespan reduction by affecting insulin and AMPK signals in Caenorhabditis elegans

Chemosphere, Journal Year: 2024, Volume and Issue: 363, P. 142975 - 142975

Published: July 29, 2024

Language: Английский

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Nanoplastic at environmentally relevant concentrations induces toxicity across multiple generations associated with inhibition in germline G protein-coupled receptor CED-1 in Caenorhabditis elegans

Chemosphere, Journal Year: 2024, Volume and Issue: 364, P. 143011 - 143011

Published: Aug. 3, 2024

Language: Английский

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