Inhalation exposure to tire rubber particle-sourced pollutant 6PPD-quinone involving basolateral amygdala impairment in male ICR mice

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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ADB-FUBINACA-induced developmental toxicity, neurotoxicity, and cardiotoxicity in embryonic zebrafish (Danio rerio)

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121517 - 121517

Published: April 1, 2025

Language: Английский

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Assessment of the Risk to Human Health and Pollution Levels Due to the Presence of Metal(loid)s in Sediments, Water, and Fishes in Urban Rivers in the State of Mato Grosso do Sul, Brazil

Urban Science, Journal Year: 2025, Volume and Issue: 9(4), P. 114 - 114

Published: April 5, 2025

This study aimed to assess the pollution levels, sources, ecological risk, and human health risks of metal(loid)s in water, sediment, muscle tissue Prochilodus lineatus Pimelodus maculatus from rivers state Mato Grosso do Sul, Brazil. The content river fish were determined by inductively coupled plasma optical emission spectrometry. Sediment assessment was carried out geo-accumulation index, contamination factor, enrichment load index. There significant differences concentration values for Al, As, Cd, Co, Cr, Cu, Mo, Ni, Pb, Hg. greater tendency elements N, Hg, Co waters Anhanduí River 2020 Cr Pb 2021. concentrations Hg are above permitted limit heavy metal ions drinking water established WHO. metals sediments set Conama/Brazil other countries. very highly contaminated Cd with moderate Pb. All showed a decline site quality, which indicates that it is polluted. Sediments classified severe Mo. Al highest P. relation analyzed. also presence such as tissues species. Therefore, these concern due consumption fish, since there carcinogenic risk related mainly As Cd.

Language: Английский

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Transcriptomic Point of Departure (tPOD) of androstenedione in zebrafish embryos as a potential surrogate for chronic endpoints

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 953, P. 176026 - 176026

Published: Sept. 3, 2024

The transcriptomic Point of Departure (tPOD) is increasingly used in ecotoxicology to derive quantitative endpoints from RNA sequencing studies. Utilizing data zebrafish embryos as a New Approach Methodology (NAM) beneficial due its acknowledgment an alternative animal testing under EU Directive 2010/63/EU. Transcriptomic profiles are available for various modes action (MoA). limited literature suggest that tPOD values Fish Embryo Toxicity (FET) tests align with, but generally lower than, No Observed Effect Concentrations (NOEC) long-term chronic fish toxicity tests. In studies with the androgenic hormone androstenedione Sexual Development Test (FSDT), significant shift sex ratio towards males was noted at all test concentrations, making it impossible determine NOEC (NOEC <4.34 μg/L). To avoid additional repetition FSDT and adhere 3Rs principle (replacement, reduction, refinement), modified FET (zFET) conducted aiming regulatory acceptable effect threshold. This involved concentration ranges (20 6105 ng/L), overlapping masculinization-observed concentrations FSDT. analysis zFET showed consistent results previous findings, observing strong expression changes androgen-dependent genes higher not ones, demonstrating concentration-response relationship. were determined 24 ng/L (10th percentile), 60 (20th gene), 69 (1st peak). 10th percentile value 200 times than lowest Comparing suggests their potential inform on range

Language: Английский

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Arsenic exposure at environmentally relevant levels induced metabolic toxicity in development mice: Mechanistic insights from integrated transcriptome and metabolome

Environment International, Journal Year: 2024, Volume and Issue: 190, P. 108819 - 108819

Published: June 14, 2024

Emerging evidence has linked arsenic exposure and metabolic homeostasis, but the mechanism is incompletely understood, especially at relatively low concentrations. In this study, we used a mouse model to evaluate health impacts toxicity of in drinking water environmentally relevant levels (0.25 1.0 ppm). Our results indicated that damaged intestinal barrier induced accumulation, oxidative stress, pathological changes liver illum. Interestingly, increased hepatic triglyceride (TG) total cholesterol (TC), while reduced serum TG TC levels. The transcriptome found caused perturbation promoted lipid accumulation by regulating exogenous fatty acids degradation apolipoproteins related genes. metabolomics identified 74 88 differential metabolites 0.25 ppm, respectively. KEGG disease subcellular location analysis diseases, mitochondrion might be target organelle for arsenic-induced toxicity. Co-enrichment metabolome 24 9 genes as biomarkers. Moreover, 40 male (20 nonalcoholic (NAFLD) cases 20 healthy controls) was further selected validate our findings. Importantly, significantly changed L-palmitoylcarnitine, 3-hydroxybutyric acid, 2-hydroxycaproic acid 6 Hadha, Acadl, Aldh3a2, Cpt1a, Cpt2, Acox1 were NAFLD cases. from integrated multi-omics chemical-protein network L-palmitoylcarnitine played critical role mitochondrial β-oxidation (Cpt1a, Cpt2). conclusion, these findings provided new clues levels, which involved late-life development. also contribute understanding human responses phenotypic hazardous material environment.

Language: Английский

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Early-life malnutrition role in memory, emotional behavior and motor impairments in early brain lesions with potential for neurodevelopmental disorders: a systematic review with meta-analysis

Nutritional Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: July 4, 2024

The present study aims to evaluate the impact of early exposure brain injury and malnutrition on episodic memory behavior.

Language: Английский

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Novel insight into deriving remediation goals of arsenic contaminated sites with multi-media-equivalent dose and local exposure parameters

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 482, P. 136501 - 136501

Published: Nov. 14, 2024

Language: Английский

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Impacts of hexafluoropropylene oxide tetrameric acid (HFPO-TeA) on neurodevelopment and GABAergic signaling in zebrafish larvae

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 289, P. 117424 - 117424

Published: Nov. 30, 2024

Language: Английский

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