Size-dependent ecotoxicological impacts of tire wear particles on zebrafish physiology and gut microbiota: implications for aquatic ecosystem health

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137215 - 137215

Published: Jan. 16, 2025

Language: Английский

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The role of gut microbiota in MP/NP-induced toxicity

Environmental Pollution, Journal Year: 2024, Volume and Issue: 359, P. 124742 - 124742

Published: Aug. 15, 2024

Language: Английский

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Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Micro- and nanoplastics, particularly those derived from food-contact materials like polyethylene terephthalate (PET), can damage gut barriers, making the gastrointestinal system more vulnerable to inflammation infections. Here, a probiotic-based drug delivery (EcNT@L) is devised mitigate nanoplastics-induced barrier dysfunction by modulating immunity microbiota. Escherichia coli Nissle 1917 (EcN) genetically engineered produce transforming growth factor-β (TGF-β) then modified with an Eudragit L100-55 coating. This probiotic acts as in vivo "drug factory", exerting anti-inflammatory immune-regulatory effects, improved retention bioavailability tract. EcNT@L effectively protects Caco-2 cells infections induced nano PET, primarily activating NF-κB signaling pathway. Besides, demonstrates superior therapeutic efficacy treating infection caused combined presence of PET Salmonella, outperforming commercial antibiotics due its ability modulate immune responses study highlights potential systems addressing dysfunctions, offering promising strategy for mitigating environmental impact micro- nanoplastics.

Language: Английский

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Autoinducer-2 signaling promotes intestinal colonization of Aeromonas veronii and induces cell apoptosis in loach ( Misgurnus anguillicaudatus )

Applied and Environmental Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

ABSTRACT Quorum sensing systems, particularly autoinducer-2 (AI-2) signaling, have significant effects on bacterial colonization and virulence. However, how they affect intestinal by pathogens subsequent host immune responses remains unclear. Here, we investigated the influence of AI-2 signaling ability Aeromonas veronii Z12 host’s response. We found that promoted A. to intestine loach ( Misgurnus anguillicaudatus ) caused severe damage, while D-ribose, an inhibitor, effectively inhibited . Transcriptomic sequencing elucidated molecular mechanism this revealing upregulation p53 pathway genes associated with apoptosis. Furthermore, microbiota dysbiosis induced was cell apoptosis, leading nitrite accumulation, which increased intracellular reactive oxygen species (ROS) levels, activated pathway, induction These findings provide insights into interaction among quorum sensing, microbiota, response, highlight potential therapeutic targets for mitigating bacterial-induced damage. IMPORTANCE The regulated its response not been fully characterized. revealed effect apoptosis in loach. Our study demonstrated deficiency significantly reduced mitigated tissue Additionally, proteins, indicating a key role responses. Understanding these mechanisms only helps elucidate pathogenicity but also may broader pathogenic other pathogens, thus general principles pathogen–host interactions across different models. led dysbiosis, notably increase abundance Hypomicrobium sp., elevating activating inducing important complex bacterial–host interactions. regulatory clinical applications as intervention strategy, offering new directions developing treatments against infections.

Language: Английский

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Lactobacillus brevis GKJOY Supplementation Ameliorates Oxidative Stress and Reproductive Dysfunction in Male Rats with Polystyrene Microplastics-Induced Reproductive Toxicity

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4533 - 4533

Published: May 9, 2025

The growing demand for plastic products has led to an increase in human exposure microplastics (MPs). MPs have been shown detrimental effects on reproductive function, while probiotics demonstrated promise enhancing fertility. This study aimed determine the protective of Lactobacillus brevis GKJOY against damage induced by polystyrene (PS-MPs) male rats. In cell study, LC540 cells were treated with L. postbiotic (PGK), gamma-aminobutyric acid (GABA), and PS-MPs evaluate their viability reactive oxygen species (ROS) production. animal experiment, rats a low dose (GK1X, 50 mg/kg), medium (GK2X, 100 or high (GK4X, 200 mg/kg). results showed that PGK GABA reduced levels ROS protected oxidative stress. contrast, increased had harmful viability. testicular injuries caused disruption hypothalamic–pituitary–gonadal (HPG) axis decrease hormone levels. However, treatment stress pro-inflammatory cytokine levels, restored hormonal imbalances, significant improvements. effectively mitigated due its dual function as probiotic neurotransmitter modulator. conclusion, GKJOY, which functions both producer, may offer superior protection damage.

Language: Английский

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Feasibility evaluation of cottonseed protein concentrate to replace soybean meal in the diet of juvenile grass carp (Ctenopharyngodon idellus): Growth performance, antioxidant capacity, intestinal health and microflora composition

Aquaculture, Journal Year: 2024, Volume and Issue: 593, P. 741328 - 741328

Published: July 4, 2024

Language: Английский

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Microplastics colonized by Hafnia paralvei through biofilm formation regulated by c-di-GMP and cAMP promote its spread in water

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 276, P. 107127 - 107127

Published: Oct. 20, 2024

Language: Английский

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