Gender-specific effects of polystyrene nanoplastic exposure on triclosan-induced reproductive toxicity in zebrafish (Danio rerio)

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 932, P. 172876 - 172876

Published: April 29, 2024

Language: Английский

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Impact of polystyrene nanoplastics on apoptosis and inflammation in zebrafish larvae: Insights from reactive oxygen species perspective

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174737 - 174737

Published: July 14, 2024

Language: Английский

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Neurobehavioral toxicity induced by combined exposure of micro/nanoplastics and triphenyltin in marine medaka (Oryzias melastigma)

Environmental Pollution, Journal Year: 2024, Volume and Issue: 356, P. 124334 - 124334

Published: June 7, 2024

Language: Английский

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Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip

ACS Nano, Journal Year: 2024, Volume and Issue: 18(45), P. 31569 - 31585

Published: Nov. 1, 2024

Exposure to micro- and nanoplastics (MNPs) has been implicated in potential cardiotoxicity. However, vitro models based on cardiomyocyte cell lines lack crucial cardiac characteristics, while interspecies differences animal compromise the reliability of conclusions. In addition, current research predominantly focused single-time point exposures MNPs, neglecting comparative analyses injury across early late stages. Moreover, there remains a large gap understanding susceptibility MNPs under pathological conditions. To address these limitations, this study integrated organoids (COs) organ-on-a-chip (OoC) technology develop organoid-on-a-chip (COoC), which was validated for cardiotoxicity evaluation through multiple dimensions. Based COoC, we conducted dynamic observation damage caused by short- long-term exposure polystyrene (PS-NPs). Oxidative stress, inflammation, disruption calcium ion homeostasis, mitochondrial dysfunction were confirmed as mechanisms PS-NP-induced events stages, fibrosis emerged prominent feature Notably, low-dose exacerbated myocardial infarction symptoms states, despite no significant shown healthy models. conclusion, findings further deepened our cardiotoxic effects introduced promising platform assessing

Language: Английский

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Neurotoxicity and aggressive behavior induced by anesthetic etomidate exposure in zebrafish: insights from multi-omics and machine learning

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: 282, P. 107321 - 107321

Published: March 8, 2025

Language: Английский

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Assessing toxicological risk of nanoplastics contaminants in food and feed from ingestion pathway to human diseases

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 284 - 284

Published: March 12, 2025

The extensive use of plastic without an effective management system is linked to significant environmental pollution issues. The fragmentation various types waste leads the formation microplastics (MPs) and nanoplastics (NPs). NPs, measuring less than 0.1 μm pose a latent danger human food chain caused by ability traverse biological membranes MPs, potentially leading chronic diseases. widespread distribution NPs across diverse matrices their subsequent infiltration into feed chains precipitates emerging health concerns. contaminate production systems leach from packaging, infiltrating organisms at trophic levels. Seafood, processed foods, drinking water serve as vectors for absorption accumulation in tissues. pervasive contamination pathway poses substantial risks through multiple exposure routes, primarily ingestion. It can lead cytotoxicity, inflammation, genotoxicity, apoptosis. This review summarizes implications that triggers diseases such inflammatory bowel disease (IBD), kidney dysfunction, liver disease, heart problems, brain disorders, reproductive issues, cancer. Currently, no established method exists treat humans may have already ingested. Hence, it urgent mitigate harmful effects development implementation innovative, efficient, sustainable decontamination strategies. discussion highlights several advanced remediation techniques effectively reduce toxicity systems, thus mitigating associated risks.

Language: Английский

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Developmental Neurotoxicity of Anesthetic Etomidate in Zebrafish Larvae: Alterations in Motor Function, Neurotransmitter Signaling, and Lipid Metabolism

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138598 - 138598

Published: May 1, 2025

Language: Английский

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Polystyrene nanoplastics mediate skeletal toxicity through oxidative stress and the BMP pathway in zebrafish (Danio rerio)

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117096 - 117096

Published: Sept. 23, 2024

Language: Английский

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Polystyrene nanoplastics alter intestinal toxicity of 2,4-DTBP in a sex-dependent manner in zebrafish (Danio rerio)

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 478, P. 135585 - 135585

Published: Aug. 22, 2024

Language: Английский

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Polystyrene nanoplastics induced learning and memory impairments in mice by damaging the glymphatic system

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116874 - 116874

Published: Aug. 16, 2024

The excessive usage of nanoplastics (NPs) has posed a serious threat to the ecological environment and human health, which can enter brain then result in neurotoxicity. However, research on neurotoxic effects NPs based different exposure routes modifications functional groups is lacking. In this study, neurotoxicity induced by was studied using polystyrene (PS-NPs) (PS, PS-COOH, PS-NH

Language: Английский

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