Associations of systemic inflammation and systemic immune inflammation with serum uric acid concentration and hyperuricemia risk: the mediating effect of body mass index DOI Creative Commons

Yueyue Zhang,

Shichao Han, Zhizhou Duan

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

With the development of lifestyle, elevated uric acid and hyperuricemia have become important factors affecting human health, but biological mechanism risk are still unclear.

Language: Английский

Health Impacts of Per- and Polyfluoroalkyl Substances (PFASs): A Comprehensive Review DOI Creative Commons
Csilla Mišľanová, Martina Valachovičová

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 573 - 573

Published: April 1, 2025

Per- and polyfluoroalkyl substances (PFASs) are among the persistent organic pollutants characterized by their persistence in environment, high mobility, adverse impact not only on ecosystem but also human health. The biggest challenges biomonitoring low concentrations of PFASs biological matrices presence matrix interferents samples. combination liquid chromatography with tandem mass spectrometry (LC-MS/MS) solid-phase extraction (SPE) as a sample preparation technique appears to be most suitable solution for achieving desired selectivity sensitivity PFAS determination. aim this review is describe possible sources PFASs, various matrices, analytical methods determining different using pretreatment techniques complex samples, well health risks associated exposure. studied include PFOA PFOS, which frequently detected such plasma, serum, breast milk. average range from 1.0 2.6 ng.mL−1 1.9 2.4 0.4 3.1 For were 2.0–4.0 ng.mL−1, 3.7–4.6 3.6–4.8 milk, respectively. significant effects exposure long-chain (such PFOS) lipid disorders, hypertension, diabetes mellitus, thyroid infertility, cancer, obesity, autism, neurodevelopmental issues, cardiovascular diseases, kidney liver disorders. It utmost importance monitor exposure, predict toxicity, develop effective strategies mitigate potential

Language: Английский

Citations

0
The association between serum uric acid and depression among U.S. National Health and Nutrition Examination Survey DOI Creative Commons
Hong S. He, Ping Li,

Haokun Huang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 8, 2025

Previous studies have suggested that serum uric acid (UA) may influence depression through oxidative stress pathways, but with inconclusive results. This study aimed to investigate the association between UA levels and depression, as well potential variations across demographic subgroups in U.S. adult population. A cross-sectional analysis of 23,059 participants from NHANES (2013-2018) was conducted. Serum were classified into quartiles, measured using Patient Health Questionnaire-9 (PHQ-9), a score ≥ 10 indicating depression. Weighted logistic regression models used analyze adjusting for clinical covariates. Subgroup analyses performed assess by sex, age, race/ethnicity, other health-related factors. Participants highest quartile had lower prevalence compared those lowest (13.9% vs. 16.2%, p = 0.004). After covariates, higher significantly associated reduced risk (OR 0.76, 95% CI: 0.67, 0.86, < 0.001 4). indicated significant interactions age (p interaction 0.051), race/ethnicity 0.027), history cardiovascular disease 0.005), more pronounced inverse associations observed among older adults, races disease. Higher inversely especially races, age. Further research is needed confirm these findings underlying mechanisms.

Language: Английский

Citations

0
Per- and Polyfluoroalkyl Substances (PFAS) in Snow, River, and Drinking Waters from a Typical Rural Area of Shandong, China DOI
Xingying Li,

Zong-Xi Zhao,

Jinxin Zi

et al.

Exposure and Health, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Language: Английский

Citations

0
Per- and poly-fluoroalkyl substances (PFAS) accelerate biological aging mediated by increased C-reactive protein DOI

Zong-Xi Zhao,

Jiayan Zhou,

Anye Shi

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136090 - 136090

Published: Oct. 9, 2024

Language: Английский

Citations

3
Associations of exposure to phthalate with serum uric acid and hyperuricemia risk, and the mediating role of systemic immune inflammation DOI Creative Commons
Zhiping Niu, Tianyi Chen, Zhizhou Duan

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 287, P. 117269 - 117269

Published: Nov. 1, 2024

Previous studies found that urinary phthalates (PAEs) metabolites may be associated with increased serum uric acid concentration and hyperuricemia risk. However, no population-based study has investigated the underlying biological mechanisms.

Language: Английский

Citations

2
Association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate: Mediating role of serum albumin DOI Creative Commons

Hua Fang,

Huajing Chang,

Danjing Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 290, P. 117599 - 117599

Published: Dec. 27, 2024

Language: Английский

Citations

2
Dissect the association between per- and polyfluoroalkyl substances (PFAS) and kidney function from the perspective of lipid molecules DOI
Yiran Chen,

Lin Shaobin,

Jiayun Lv

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 361, P. 124865 - 124865

Published: Aug. 30, 2024

Language: Английский

Citations

1
Kidney function mediates the effects of four per-and polyfluoroalkyl substances (PFAS) on atherosclerotic cardiovascular disease DOI Creative Commons
Zhengqi Wei,

Keke Wei,

Ming Yang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 288, P. 117395 - 117395

Published: Nov. 27, 2024

Language: Английский

Citations

1
Tinospora crispa (L.) Hook.f. & Thomson vines ameliorates hyperuricemia by inhibiting synthesis and promoting excretion of uric acid through targeting NLRP3/caspase-1/IL-1β pathway DOI

N. Chen,

Dandan Liu, Zhonghu He

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119271 - 119271

Published: Dec. 1, 2024

Language: Английский

Citations

1
Thyrotoxic Effects of Mixed Exposure to Perfluorinated Compounds: Integrating Population-Based, Toxicogenomic, Animal, and Cellular Evidence to Elucidate Molecular Mechanisms and Identify Potential Effector Targets DOI

Xiushuai Du,

Xueming Xu,

Hongjie Yu

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are emerging environmental endocrine disruptors that may adversely affect the human system, particularly thyroid gland, largest gland in body. An epidemiologic survey was conducted involving 318 community residents Shanghai, China, to assess PFAS exposure levels. The relationship between five function indicators analyzed using Bayesian Kernel Regression (BKMR) Weighted Quantile Sum (WQS). Ten effector genes related diseases were identified through Comparative Toxicogenomics Database (CTD) for bioinformatics analysis pathways involved explored mediation analysis. In vivo validation of these PCR, complemented by vitro cellular experiments transcriptome sequencing construction animal models simulate mixed general population. Mixed found impact health primarily lipid metabolism toxicogenomic studies resulted upregulation key associated with models. Our results demonstrate could expression modulation transcription factors, contributing development disease.

Language: Английский

Citations

1