Effects of environmental bisphenol S exposure on male rat reproductive health and gut-blood-testicular axis integrity

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117646 - 117646

Published: Jan. 1, 2025

In this study, male Sprague-Dawley (SD) rats were exposed to bisphenol S (BPS) at environmentally relevant concentrations investigate its reproductive toxicity and evaluate effects on the gut-blood-testicular axis. After 28 days of exposure BPS (0.05 20 mg/kg), results showed a reduction in weight gain induction rats, including decreased sperm parameters, lower viability, increased abnormal density mortality. These observations made by counting with hemocytometer under optical microscope. 16S rRNA untargeted metabolomic elucidated potential impacts axis: impaired physical barrier, evoked inflammation, resulted dysbiosis gut microbiota. Additionally, altered serum metabolites, phosphatidic acid diacylglycerol, which are involved Fc gamma R-mediated phagocytosis linked inflammation. Furthermore, histopathological analysis, western blot (WB), enzyme-linked immunosorbent assay (ELISA), immunofluorescence that led testicular damage, activation p38 ERK MAPK pathways, disruption blood-testis barrier (BTB). Collectively, these findings indicate impair intestinal health, disrupt microbiome, ultimately lead dysfunction through

Language: Английский

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Polystyrene microplastics affect the early life stages of large yellow croaker Pseudosciaena crocea

Journal of Oceanology and Limnology, Journal Year: 2025, Volume and Issue: 43(2), P. 644 - 655

Published: March 1, 2025

Language: Английский

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Behavioral impairments and disrupted mitochondrial energy metabolism induced by polypropylene microplastics in zebrafish larvae

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 947, P. 174541 - 174541

Published: July 6, 2024

Language: Английский

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Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip

ACS Nano, Journal Year: 2024, Volume and Issue: 18(45), P. 31569 - 31585

Published: Nov. 1, 2024

Exposure to micro- and nanoplastics (MNPs) has been implicated in potential cardiotoxicity. However, vitro models based on cardiomyocyte cell lines lack crucial cardiac characteristics, while interspecies differences animal compromise the reliability of conclusions. In addition, current research predominantly focused single-time point exposures MNPs, neglecting comparative analyses injury across early late stages. Moreover, there remains a large gap understanding susceptibility MNPs under pathological conditions. To address these limitations, this study integrated organoids (COs) organ-on-a-chip (OoC) technology develop organoid-on-a-chip (COoC), which was validated for cardiotoxicity evaluation through multiple dimensions. Based COoC, we conducted dynamic observation damage caused by short- long-term exposure polystyrene (PS-NPs). Oxidative stress, inflammation, disruption calcium ion homeostasis, mitochondrial dysfunction were confirmed as mechanisms PS-NP-induced events stages, fibrosis emerged prominent feature Notably, low-dose exacerbated myocardial infarction symptoms states, despite no significant shown healthy models. conclusion, findings further deepened our cardiotoxic effects introduced promising platform assessing

Language: Английский

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Nobiletin‐mediated autophagy mitigates nanoplastic‐induced toxicity in human intestinal Caco‐2 cells

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(6)

Published: March 11, 2025

Abstract The presence of nanoplastics (NPs), which cause oxidative stress and damage to the cell structure due breakdown microplastics (MPs), poses considerable ecological health challenges. This study investigated protective role nobiletin (NOB), a flavonoid derived from citrus peel, in modulating autophagy mitigating NP‐induced toxicity human intestinal Caco‐2 cells. cells were treated with NPs varying concentrations NOB evaluate viability, apoptosis, autophagic activity. We observed that exposure resulted concentration‐dependent decrease viability an increase expression apoptosis markers. Exposure reduced disrupted processes by decreasing LC3B increasing p62 levels, indicating impaired autophagy. treatment reversed these effects enhancing activity upregulating downregulating p62. Furthermore, improved lysosomal integrity decreased apoptotic markers such as Bax cleaved caspase‐3 while Bcl‐2 expression. also facilitated nuclear translocation transcription factor EB through activating AMP‐activated protein kinase (AMPK) inhibiting mechanistic target rapamycin (mTOR), promoting cellular detoxification homeostasis. has potential therapeutic agent leverages pathway mitigate adverse NPs, suggesting novel approach for managing

Language: Английский

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Perfluorobutane Sulfonate (PFOS) Accumulation in Tissues of Cherax quadricarinatus and Its Toxicity Mechanism

Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 269 - 269

Published: April 1, 2025

Perfluoroctane sulfonate (PFOS) is an emerging pollutant widely existing in aquatic environments that has attracted many scholars’ attention. Cherax quadricarinatus (C. quadricarinatus) are crustaceans live freshwater environments. This study aimed to investigate the long-term toxic exposure effect of PFOS on C. quadricarinatus. Three environment concentrations (1 ng/L, 100 and 10 μg/L) were set for 28 days The results indicated was detected serum, muscle, hepatopancreas quadricarinatus, order accumulation levels as follows: > serum muscle. Furthermore, transcriptomics showed function differentially expressed genes (DEGs) groups related biological processes, metabolism, organic system, immune response. Kyoto Encyclopedia Genes Genomes enrichment analysis DEGs significantly enriched lysosome signaling pathway, retinol binding, fructose mannose glutathione etc., pathway most significant, which key effects

Language: Английский

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Biodegradation of polystyrene by Spodoptera litura and Spodoptera frugiperda larvae (Lepidoptera: Noctuidae): Insights into the frass characterization and responses of gut microbiomes

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 492, P. 138178 - 138178

Published: April 6, 2025

Language: Английский

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Aged polystyrene microplastics exacerbate cadmium-induced hepatotoxicity in zebrafish through gut-liver axis metabolic dysregulation

Environmental Chemistry and Ecotoxicology, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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MetOrigin 2.0: Advancing the discovery of microbial metabolites and their origins

iMeta, Journal Year: 2024, Volume and Issue: 3(6)

Published: Nov. 6, 2024

First introduced in 2021, MetOrigin has quickly established itself as a powerful web server to distinguish microbial metabolites and identify the bacteria responsible for specific metabolic processes. Building on growing understanding of interplay between microbiome metabolome, response user feedback, undergone significant upgrade version 2.0. This enhanced incorporates three new modules: (1) Quick search module that facilitates rapid identification associated with particular metabolite; (2) Orthology analysis links enzyme genes their corresponding bacteria; (3) Mediation investigates potential causal relationships among bacteria, metabolites, phenotypes, highlighting mediating role metabolites. Additionally, backend database been updated latest data from seven public databases (KEGG, HMDB, BIGG, ChEBI, FoodDB, Drugbank, T3DB), expanded coverage 210,732 each linked its source organism. 2.0 is freely accessible at http://metorigin.met-bioinformatics.cn.

Language: Английский

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Enhanced Effects of Polystyrene Nanoplastics and Imidacloprid on Organ Damage in Loaches(Misgurnus Anguillicaudatus): Disrupted Gene Expression Leads to Imbalance in Lipid Metabolism

Published: Jan. 1, 2025

Language: Английский

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