Engineered Polymeric Microspheres with Synergistic Hydrogen‐Bonding Nanotraps and Multisite Adsorption for Ultrafast Herbicide Decontamination

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

The ultrafast removal of trace herbicides like paraquat (PQ) and diquat (DQ) from water is urgent yet challenging due to their highwater stability strong binding properties. Here, efficient PQ DQ based on hydrogen-bonding nanotraps dominant multi-site adsorption were developed. Two crosslinked polymeric microspheres, βCD-PF γCD-PF, synthesized cyclodextrins (CDs) hexafluorocyclotriphosphazene (HFP). γCD-PF microsphere with sufficient hydrogen bonding the pore surface prompts kinetics constants up 127.09 192.64 g mg-1 min-1, achieving 99% efficiency for within 5 s. exhibits exceptional selectivity over larger competing dyes. Importantly, (1 ppm) can be effectively treated achieve a concentration far below U.S. EPA standard (0.003 30 seconds. driven by mechanism: electrostatic π-π interactions HFP promote adsorbate accumulation CD surface, while high-density in enhance bond strength, enabling rapid capture. This work provides valuable strategy designing adsorbents effective herbicide water.

Language: Английский

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Engineered Polymeric Microspheres with Synergistic Hydrogen‐Bonding Nanotraps and Multisite Adsorption for Ultrafast Herbicide Decontamination

Angewandte Chemie, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract The ultrafast removal of trace herbicides like paraquat (PQ) and diquat (DQ) from water is urgent yet challenging due to their highwater stability strong‐binding properties. Here, efficient PQ DQ based on hydrogen‐bonding nanotraps dominant multisite adsorption were developed. Two crosslinked polymeric microspheres, β CD‐PF γ CD‐PF, synthesized cyclodextrins (CDs) hexafluorocyclotriphosphazene (HFP). microsphere with sufficient the pore surface prompts kinetics constants up 127.09 192.64 g mg −1 min , achieving 99% efficiency for within 5 s. exhibits exceptional selectivity over larger competing dyes. Importantly, (1 ppm) can be effectively treated achieve a concentration far below US Environmental Protection Agency (EPA) standard (0.003 30 driven by mechanism: electrostatic π–π interactions HFP promote adsorbate accumulation CD surface, while high‐density in enhance hydrogen bond strength, enabling rapid capture. This work provides valuable strategy designing adsorbents effective herbicide water.

Language: Английский

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Jujuboside A in Ameliorating insomnia in Mice via GABAergic Modulation of the PVT

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119939 - 119939

Published: May 1, 2025

Ziziphus jujuba var. spinosa (Bunge) Hu ex H. F. Chow (ZSS), a traditional Chinese medicinal herb, has been historically used to treat insomnia and neurological disorders. Jujuboside A, triterpenoid saponin isolated from ZSS, represents its core bioactive component with purported sedative properties, yet mechanism of action remains underexplored. To validate the anti-insomnia efficacy A elucidate GABAergic regulatory mechanisms through integrated in vivo vitro approaches. chronic sleep deprivation mouse model was established using modified multi-platform water environment. Behavioral assessments (open-field test, pentobarbital-induced test) were combined histopathological analysis (H&E staining), flow cytometry (apoptosis), ELISA (GABA/ Glu quantification), Western blot (GABA A/GABA B, NMDA/AMPA receptors). Pharmacological inhibition GABA signaling performed GABA-IN-1. significantly shortened latency prolonged duration vs. group. Histopathology revealed A-mediated restoration hippocampal neuronal density mitigation nuclear pyknosis. upregulated levels while suppressing apoptosis, concomitant increases B receptor expression. Crucially, GABA-IN-1 abolished these therapeutic effects, confirming dependency. ameliorates by restoring GABA/Glu homeostasis enhancing expression, thereby validating ZSS's use modern pharmacological evidence.

Language: Английский

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Characterizing microglial heterogeneity in autophagy impairment of Paraquat-induced Parkinson’s disease-like neurodegeneration

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 299, P. 118364 - 118364

Published: May 21, 2025

Language: Английский

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Brain single-cell transcriptomics highlights comorbidity-related cell type-specific changes of Parkinson’s disease with major depressive disorder after paraquat exposure

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117193 - 117193

Published: Oct. 16, 2024

Language: Английский

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