Effect of Alternating Electric Field Induced by Cold Atmospheric Plasma on the Conformation and Function of Interleukin-6 DOI Open Access

Ren-Fang Xing,

Ming Chen, Ruiyu Li

et al.

Acta Physica Sinica, Journal Year: 2024, Volume and Issue: 73(18), P. 188703 - 188703

Published: Jan. 1, 2024

Cold atmospheric plasma (CAP) is considered to be a very promising cancer treatment method due its “selective” killing effect on cells. The CAP can inhibit tumor inflammatory responses and activate the immune system by reducing expression of key factor Interleukin-6 (IL-6). However, influence strong alternating electric field induced conformation function IL-6 remains unclear. In this study molecular dynamics simulation used investigate effects fields with different frequencies intensities IL-6. We statistically analyze root mean square fluctuations, deviation, secondary structural alterations, dipole moment changes under parameters. Furthermore, docking utilized assess receptor-binding process. results show that when frequency below 30 MHz intensity exceeds 0.5 V/nm, average increases, leading in rigid regions at C-terminus which maintain stability. Specifically, salt bridges stabilize long helices rupture, number α-helices decreases. outcomes reveal distance between binding residues conformationally altered receptor thereby disrupting normal process potentially impairing biological functionality. This explains internal interaction mechanism CAP-induced affecting IL-6-related micro level, provides important theoretical basis for optimizing parameters practical application inflammation development effective therapy strategies.

Language: Английский

A light-responsive multilayered 3D porous Ga2O3 hydrogel for photocatalytic antibacterial therapy promoting healing of MDR S. aureus-infected wounds DOI
Yimei Wang,

X M Shi,

S. Hou

et al.

Journal of Material Science and Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

1
Physicochemical properties and antimicrobial efficacy of argon cold atmospheric pressure plasma jet activated liquids – a comparative study DOI Creative Commons
Sarthak Das, Sarita Mohapatra, Satyananda Kar

et al.

Fundamental Plasma Physics, Journal Year: 2024, Volume and Issue: 12, P. 100078 - 100078

Published: Nov. 3, 2024

Language: Английский

Citations

0
Effect of Alternating Electric Field Induced by Cold Atmospheric Plasma on the Conformation and Function of Interleukin-6 DOI Open Access

Ren-Fang Xing,

Ming Chen, Ruiyu Li

et al.

Acta Physica Sinica, Journal Year: 2024, Volume and Issue: 73(18), P. 188703 - 188703

Published: Jan. 1, 2024

Cold atmospheric plasma (CAP) is considered to be a very promising cancer treatment method due its “selective” killing effect on cells. The CAP can inhibit tumor inflammatory responses and activate the immune system by reducing expression of key factor Interleukin-6 (IL-6). However, influence strong alternating electric field induced conformation function IL-6 remains unclear. In this study molecular dynamics simulation used investigate effects fields with different frequencies intensities IL-6. We statistically analyze root mean square fluctuations, deviation, secondary structural alterations, dipole moment changes under parameters. Furthermore, docking utilized assess receptor-binding process. results show that when frequency below 30 MHz intensity exceeds 0.5 V/nm, average increases, leading in rigid regions at C-terminus which maintain stability. Specifically, salt bridges stabilize long helices rupture, number α-helices decreases. outcomes reveal distance between binding residues conformationally altered receptor thereby disrupting normal process potentially impairing biological functionality. This explains internal interaction mechanism CAP-induced affecting IL-6-related micro level, provides important theoretical basis for optimizing parameters practical application inflammation development effective therapy strategies.

Language: Английский

Citations

0