Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 125077 - 125077
Published: Oct. 1, 2024
Language: Английский
Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 125077 - 125077
Published: Oct. 1, 2024
Language: Английский
Environment International, Journal Year: 2025, Volume and Issue: 198, P. 109420 - 109420
Published: March 30, 2025
Language: Английский
Citations
1ACS Nano, Journal Year: 2024, Volume and Issue: 18(45), P. 31569 - 31585
Published: Nov. 1, 2024
Exposure to micro- and nanoplastics (MNPs) has been implicated in potential cardiotoxicity. However, vitro models based on cardiomyocyte cell lines lack crucial cardiac characteristics, while interspecies differences animal compromise the reliability of conclusions. In addition, current research predominantly focused single-time point exposures MNPs, neglecting comparative analyses injury across early late stages. Moreover, there remains a large gap understanding susceptibility MNPs under pathological conditions. To address these limitations, this study integrated organoids (COs) organ-on-a-chip (OoC) technology develop organoid-on-a-chip (COoC), which was validated for cardiotoxicity evaluation through multiple dimensions. Based COoC, we conducted dynamic observation damage caused by short- long-term exposure polystyrene (PS-NPs). Oxidative stress, inflammation, disruption calcium ion homeostasis, mitochondrial dysfunction were confirmed as mechanisms PS-NP-induced events stages, fibrosis emerged prominent feature Notably, low-dose exacerbated myocardial infarction symptoms states, despite no significant shown healthy models. conclusion, findings further deepened our cardiotoxic effects introduced promising platform assessing
Language: Английский
Citations
5Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 125077 - 125077
Published: Oct. 1, 2024
Language: Английский
Citations
4