Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip

ACS Nano, Journal Year: 2024, Volume and Issue: 18(45), P. 31569 - 31585

Published: Nov. 1, 2024

Exposure to micro- and nanoplastics (MNPs) has been implicated in potential cardiotoxicity. However, vitro models based on cardiomyocyte cell lines lack crucial cardiac characteristics, while interspecies differences animal compromise the reliability of conclusions. In addition, current research predominantly focused single-time point exposures MNPs, neglecting comparative analyses injury across early late stages. Moreover, there remains a large gap understanding susceptibility MNPs under pathological conditions. To address these limitations, this study integrated organoids (COs) organ-on-a-chip (OoC) technology develop organoid-on-a-chip (COoC), which was validated for cardiotoxicity evaluation through multiple dimensions. Based COoC, we conducted dynamic observation damage caused by short- long-term exposure polystyrene (PS-NPs). Oxidative stress, inflammation, disruption calcium ion homeostasis, mitochondrial dysfunction were confirmed as mechanisms PS-NP-induced events stages, fibrosis emerged prominent feature Notably, low-dose exacerbated myocardial infarction symptoms states, despite no significant shown healthy models. conclusion, findings further deepened our cardiotoxic effects introduced promising platform assessing

Language: Английский

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Adolescent exposure to micro/nanoplastics induces cognitive impairments in mice with neuronal morphological damage and multi-omic alterations

Environment International, Journal Year: 2025, Volume and Issue: 197, P. 109323 - 109323

Published: Feb. 7, 2025

Polystyrene micro/nanoplastics (MPs/NPs) are globally recognized environmental concerns due to their widespread pollution and detrimental effects on physiological functions. However, the neurotoxic underlying mechanisms of MPs/NPs brain function in adolescents remain incompletely understood. This study investigated polystyrene neurobehavioral adolescent mice, utilizing multi-omic analysis molecular biology assays explore potential mechanisms. Following oral exposure MPs (5 μm) or NPs (0.5 at 0.5 mg/day for 4 weeks, induced more severe cognitive impairment mice than MPs, as assessed by Morris water maze Y-maze tests. might be associated with neuron loss neurogenesis inhibition caused NPs, while dendritic spine mediated hippocampus. Furthermore, hippocampal transcriptome Western blotting indicated involvement PI3K/AKT pathway NPs-induced neurotoxicity. Meanwhile, pronounced disruptions metabolome gut microbiota, strong correlations were observed between changes metabolites bacteria. elucidated toxicity mechanism inducing providing insights into toxicological impacts strategies intervention.

Language: Английский

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Multiomics analysis revealed the effects of polystyrene nanoplastics at different environmentally relevant concentrations on intestinal homeostasis

Environmental Pollution, Journal Year: 2025, Volume and Issue: 372, P. 126050 - 126050

Published: March 12, 2025

Language: Английский

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Elucidating the underlying toxic mechanisms of nanoplastics on zebrafish hematological and circulatory systems

Environmental Science Nano, Journal Year: 2024, Volume and Issue: 11(9), P. 3900 - 3917

Published: Jan. 1, 2024

This study demonstrates that nanoplastics disrupt early embryonic development, impair mitochondrial function, and inhibit PINK1/Parkin-mediated mitophagy, which can be mitigated with a mitophagy activator.

Language: Английский

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