Time-Resolved Levodopa Cascade Polymerization Tuned by Bimetallic MOF Fluorescent Nanozyme and Boric Acid for Butyrylcholinesterase Activity Dual-Mode Assay DOI
Qi Xu, Shuo Wang, Zhiwen Gan

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

A ratiometric fluorescence-photothermal dual-mode assay method is constructed for the detection of butyrylcholinesterase (BChE) activity based on time-resolved levodopa (L-DOPA) cascade polymerization. First, a newly designed bimetallic metal–organic framework (MOF), Eu/Co-DPA (DPA: pyridine-2,6-dicarboxylic acid), screened out as fluorescent nanozyme with high catalytic and superior luminescence properties. In presence boric acid (BA), L-DOPA forms BA-esterified L-DOPA, which catalyzed by to form oligomers strong blue fluorescence. Meanwhile, red fluorescence quenched oligomers, generating sensitive turn-on/off response. As polymerization time increases, cleaves borate ester bonds expose catechol structures facilitates further oxidation promoting formation poly(L-DOPA) nanoparticles photothermal conversion efficiency (30.33%). Then, using thiocholine (butyrylthiocholine enzymolysis product) inhibit Eu/Co-DPA, BChE detected through change in dual signals. Both modes have low limits (0.021 0.024 U L–1) accuracy (93.3–105.3% recovery). The results real human serum indicate that both show 100.0% agreement standard method. To our knowledge, this work first combines MOFs BA regulator tune structure polymers, providing pathbreaking paradigm preparing catecholamine-based organic polymers.

Language: Английский

Smartphones as a platform for molecular analysis: concepts, methods, devices and future potential DOI Creative Commons
D. G. Baker,

Jasmine Bernal-Escalante,

Christine Traaseth

et al.

Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Smartphones have the potential to transform chemical and biological analysis by functioning as portable, versatile, democratized platforms for molecular diagnostics. Recent advances in optical detection devices are reviewed.

Language: Английский

Citations

0
Construction of CuNCs/AgNPs based fluorescent platform for specific enzyme-free detection of trichlorfon DOI
Songrui Li, Fubin Yang, Junying Li

et al.

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 344030 - 344030

Published: April 1, 2025

Language: Английский

Citations

0
Recent development of nanozymes for dual and multi-mode biosensing applications in food safety and environmental monitoring: a review DOI
Sofiène Mansouri,

Ahmed Al Omary

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 116832 - 116832

Published: April 1, 2025

Language: Английский

Citations

0
Fluorescent Nanozyme for the Dual-mode Detection of Tetracycline: Aggregation-induced Luminescence and Boosting Peroxidase-like Activity DOI
Tai Ye, Long Bai,

Jinsong Yu

et al.

Food Control, Journal Year: 2024, Volume and Issue: unknown, P. 111109 - 111109

Published: Dec. 1, 2024

Language: Английский

Citations

2
Recent advances toward emerging nanozymes with aggregation-induced emission DOI Creative Commons
Xin Li, Zhao Wang, Jing He

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

AIE luminogens (AIEgens) are a class of unique fluorescent molecules that exhibit significantly enhanced luminescence properties and excellent photostability in the aggregated state. Recently, it has been found some AIEgens can produce reactive oxygen species, which means they may have potential enzyme-like activities thus termed "AIEzymes". Consequently, discovery design novel with emerged as new exciting research direction. Additionally, enhance catalytic efficiency traditional nanozymes by direct combination, thereby endowing multifunctionality. In this regard, aggregation-induced emission (AIE) properties, represents win-win integration, not only take full advantage low cost stability nanozymes, but also incorporate biocompatibility fluorescence AIEgens. These synergistic compounds bring about opportunities for various applications, making AIEzymes interest biomedical research, food analysis, environmental monitoring, especially imaging-guided diagnostics. This review will provide an overview latest strategies achievements rational preparation AIEzymes, well current trends, future challenges prospective solutions. We expect work encourage motivate more people to study explore further promote their applications fields.

Language: Английский

Citations

1
A method for the rapid detection of heavy metal mercury ions based on a novel mercury chelator N,N'-bis (2-mercaptoethyl) isophthalamide DOI
Yali Wang,

Shuangbo Zhang,

Jiang Bian

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 468, P. 142486 - 142486

Published: Dec. 16, 2024

Language: Английский

Citations

1
Time-Resolved Levodopa Cascade Polymerization Tuned by Bimetallic MOF Fluorescent Nanozyme and Boric Acid for Butyrylcholinesterase Activity Dual-Mode Assay DOI
Qi Xu, Shuo Wang, Zhiwen Gan

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

A ratiometric fluorescence-photothermal dual-mode assay method is constructed for the detection of butyrylcholinesterase (BChE) activity based on time-resolved levodopa (L-DOPA) cascade polymerization. First, a newly designed bimetallic metal–organic framework (MOF), Eu/Co-DPA (DPA: pyridine-2,6-dicarboxylic acid), screened out as fluorescent nanozyme with high catalytic and superior luminescence properties. In presence boric acid (BA), L-DOPA forms BA-esterified L-DOPA, which catalyzed by to form oligomers strong blue fluorescence. Meanwhile, red fluorescence quenched oligomers, generating sensitive turn-on/off response. As polymerization time increases, cleaves borate ester bonds expose catechol structures facilitates further oxidation promoting formation poly(L-DOPA) nanoparticles photothermal conversion efficiency (30.33%). Then, using thiocholine (butyrylthiocholine enzymolysis product) inhibit Eu/Co-DPA, BChE detected through change in dual signals. Both modes have low limits (0.021 0.024 U L–1) accuracy (93.3–105.3% recovery). The results real human serum indicate that both show 100.0% agreement standard method. To our knowledge, this work first combines MOFs BA regulator tune structure polymers, providing pathbreaking paradigm preparing catecholamine-based organic polymers.

Language: Английский

Citations

0