Enantioselective Toxicity of Ibuprofen to Earthworms: Unraveling the Effect and Mechanism on Enhanced Toxicity of S-Ibuprofen Over R-Ibuprofen DOI

Wenqi Jiang,

Zeyu Zhao, Qi Zhao

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

With the global implementation of wastewater reuse, accurately assessing soil ecological risk chiral pollutants from necessitates a comprehensive understanding their enantioselective toxicity to animals. Ibuprofen (IBU) is most prevalent pharmaceutical in municipal wastewater. However, its toward animals and underlying mechanism remain largely unknown. In this study, IBU enantiomers, S-IBU R-IBU, earthworms was evaluated at environmentally relevant concentrations (10 100 μg/L), simulating reuse for irrigation. The results demonstrated that adversely affects growth, reproduction, regeneration, defense systems, metabolic processes earthworms, with exhibiting stronger toxic effects than R-IBU. bioavailability assessment revealed more readily absorbed by converted enantiomer within This consistent molecular docking showing had affinities functional proteins associated xenobiotic transport transformation. findings study highlight poses higher R-IBU organisms under scenarios chirality chemical deserves attention when implementing reuse. addition, our underscores differences bioactivity may account pollutants.

Language: Английский

Enantioselective Toxicity of Ibuprofen to Earthworms: Unraveling the Effect and Mechanism on Enhanced Toxicity of S-Ibuprofen Over R-Ibuprofen DOI

Wenqi Jiang,

Zeyu Zhao, Qi Zhao

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

With the global implementation of wastewater reuse, accurately assessing soil ecological risk chiral pollutants from necessitates a comprehensive understanding their enantioselective toxicity to animals. Ibuprofen (IBU) is most prevalent pharmaceutical in municipal wastewater. However, its toward animals and underlying mechanism remain largely unknown. In this study, IBU enantiomers, S-IBU R-IBU, earthworms was evaluated at environmentally relevant concentrations (10 100 μg/L), simulating reuse for irrigation. The results demonstrated that adversely affects growth, reproduction, regeneration, defense systems, metabolic processes earthworms, with exhibiting stronger toxic effects than R-IBU. bioavailability assessment revealed more readily absorbed by converted enantiomer within This consistent molecular docking showing had affinities functional proteins associated xenobiotic transport transformation. findings study highlight poses higher R-IBU organisms under scenarios chirality chemical deserves attention when implementing reuse. addition, our underscores differences bioactivity may account pollutants.

Language: Английский

Citations

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