Global impact of PM2.5 on cardiovascular disease: Causal evidence and health inequities across region from 1990 to 2021

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 374, P. 124168 - 124168

Published: Jan. 21, 2025

Language: Английский

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Epidemiological trends in gastrointestinal cancers and risk factors across U.S. states from 2000 to 2021: a systematic analysis for the global burden of disease study 2021

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 6, 2025

Gastrointestinal (GI) cancers account for over a quarter of all cancer-related deaths in the United States; however, latest trends their prevalence remain unclear. Data on GI were obtained from Global Burden Disease Study 2021. Age-standardized incidence rates (ASIR) and age-standardized mortality (ASMR) estimated across various states, sexes, ages, risk factors, annual percentage changes calculated. From 2000 to 2021, liver cancer exhibited greatest increase both ASIR ASMR, followed by pancreatic cancer. In contrast, stomach showed decline, colorectal cancer, esophageal biliary tract Most predominantly affect men tend toward younger age onset. Geographic disparities exist burden factors. For esophageal, stomach, cancers, linked diet smoking decreased, whereas alcohol-related increased several especially West Virginia. Hepatitis C remains leading cause with intravenous drug use as primary factor. Non-alcoholic steatohepatitis (NASH) is fastest-growing excessive alcohol use. Mortality due high body-mass index fasting plasma glucose have states groups. The epidemiological U.S. shifted substantially. States need implement targeted policies that address specific populations factors each type.

Language: Английский

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Particulate matter source localization in dynamic indoor environments: Bridging simulation-experimentation gaps with a 3D multi-robot system

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137474 - 137474

Published: Feb. 4, 2025

Language: Английский

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Global trends and epidemiological impact of metabolic risk factors on atrial fibrillation and atrial flutter from 1990 to 2021

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 7, 2025

Abstract Atrial fibrillation (AF) and atrial flutter (AFL) are cardiac arrhythmias associated with high morbidity mortality. This cross-sectional observational study assesses the epidemiological burden of AF/AFL concerning metabolic risk factors using Global Burden Disease (GBD) 2021 database. Age-standardized disability-adjusted life years rate (ASDR), mortality, estimated annual percentage change were calculated. The Bayesian Age-Period-Cohort model was utilized to predict future trends in ASDR age-standardized mortality (ASMR) for 2030. Between 1990 2021, rose from 34.22 34.94, whereas ASMR increased 1.46 1.50 per 100,000 people. High/high–middle Socio-Demographic Index (SDI) regions showed decreasing ASMR, low middle SDI increasing trends. In highest recorded Australasia, North America, Western Europe, significant country-level variability. Projections indicate a declining trend stable through global rise attributable necessitates comprehensive region-specific public health strategies. Further research is warranted develop implement effective measures mitigate these conditions improve cardiovascular outcomes worldwide.

Language: Английский

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Global, regional and national burden of ischaemic heart disease attributable to high body mass index and low physical activity from 1990 to 2021

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Aim This study aimed to estimate the distribution of and changes in global burden ischaemic heart disease (IHD) attributable high body mass index (BMI) low physical activity (PA) from 1990 2021. Methods Data on deaths, disability‐adjusted life years (DALYs) age‐standardized rates for IHD BMI PA were extracted Global Burden Disease 2021 study. Temporal trends by gender, region Socio‐Demographic Index (SDI) analysed using joinpoint regression. Decomposition, health inequality analysis Bayesian model utilized. Results From 2021, DALYs deaths nearly doubled, despite a decline ([average annual percent change (AAPC) = −0.26, 95% uncertainty interval (95% UI): −0.45, −0.07), (AAPC −1.03, UI:−1.18, −0.88]) ([AAPC −0.53, UI: −0.72, −0.33], [AAPC −1.13,95% −1.34, −0.92]), respectively. The due was predominantly seen males, while more prevalent females. Significant regional national variation observed, with shifting SDI regions middle or regions. Population growth aging have exacerbated this burden. Health inequities shown improvement between Projections next 15 suggest rising death BMI, those may decrease. Conclusions Since 1990, impact remains significant, disparities age, SDI. Countries should implement effective measures control promote reduce

Language: Английский

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The global prevalence of complete hearing loss in 204 countries and territories from 1992 to 2021: a systematic analysis for the global burden of disease study 2021

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: April 9, 2025

Complete hearing loss, especially the age-related type, poses a significant public health challenge globally. This study aims to assess global burden on prevalence of complete loss from 1992 2021 and forecast trends up 2036. Using data Global Burden Disease (GBD) Study 2021, we assessed across 204 countries territories. We analyzed temporal in ASPR using Joinpoint regression, evaluated contributions age, period, cohort effects through Age-Period-Cohort modeling, performed decomposition analysis determine impact demographic epidemiological changes trends. Predictions future were made Bayesian (BAPC) Autoregressive Integrated Moving Average (ARIMA) models. By had reached 9.9 million cases, with declining 134.35 117.79 per 100,000. The overall Estimated Annual Percentage Change (EAPC) was-0.45. most reductions observed low-SDI regions, particularly Sub-Saharan Africa (EAPC: -0.74). In contrast, high-SDI including North America Western Europe, showed more modest declines -0.18). Notably, East Asia exhibited 62.3% increase prevalence, high-income Pacific showing highest relative rise at 83.97%. Age-related remained dominant cause, among individuals aged 60 above. Males affected than females. Population aging growth major drivers increased while population was primary factor areas. remains high populations within despite ASPR. Significant regional disparities remain, highlighting need for targeted interventions improve access care affordable technologies regions.

Language: Английский

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Low back pain trends attributable to high body mass index over the period 1990–2021 and projections up to 2036

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 21, 2025

Background High body mass index (BMI) is a crucial determinant in low back pain (LBP) incidence and progression. However, the effect of increased BMI on LBP has been largely overlooked at global, regional, national levels. This research aimed to use data from 2021 global burden disease (GBD) study determine trends associated with due high 1990 2021, thereby providing evidence for developing targeted policies. Methods Epidemiological association between obtained GBD 2021. Disability-adjusted life-years (DALYs) attributable BMI-related are stratified by year, age, country, socio-demographic (SDI). The estimated annual percentage change (EAPC) was calculated evaluate A Bayesian age-period cohort (BAPC) model used assess corresponding 2022 2036. Additionally, statistical models, such as decomposition analysis frontier analysis, were used. Results According number DALYs caused attributed reached 8,363,759 which an increase 170.97% since 1990. age-standardized rate disability-adjusted life years (ASDR) increasing EAPC 1.14%. Among five SDI regions, ASDR increased. High-income North Americans exhibited highest risk BMI, Hungary being most affected. Frontier highlights urgent need intervention countries Netherlands, Germany, Canada. Finally, related will continue rise Conclusion Between there lower projected continuation this trend. Monitoring region-specific strategies, emphasizes urgency reducing health improving quality population.

Language: Английский

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Burden of Pulmonary Arterial Hypertension in China from 1990 to 2021, with Projections to 2050: An Analysis of Data from the Global Burden of Disease Study 2021

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Background Pulmonary arterial hypertension (PAH) is a severe condition with high morbidity and mortality, yet its epidemiology in China remains poorly understood. This study aims to assess the burden of PAH from 1990 2021 project trends 2050, providing insights for effective management prevention strategies. Method Data Global Burden Disease (GBD) Study were analyzed, focusing exclusively on PAH. Key metrics included incidence, prevalence, disability-adjusted life years (DALYs), along their corresponding age-standardized rates (ASRs). Average annual percent changes (AAPCs) calculated using joinpoint regression analysis, Bayesian age-period-cohort model was employed through 2050. Results In 2021, there 41,135 estimated prevalent cases (95% UI: 32,838.91 51,357.25) China, an prevalence rate (ASPR) 2.24 per 100,000. Females accounted approximately 58% cases. caused 7,318 deaths 4,835.72 9,075.75; 3,683 males, 3,635 females), death (ASDR) 0.42 From ASPR increased slightly 2.07 1.68 2.54) 1.81 2.75), while ASDR decreased 0.61 0.46 0.83) 0.28 0.51). Projections suggest declining both ASDR, although overall expected rise over next 30 years. Conclusion imposes significant disease particularly among women older adults. These findings highlight urgent need enhance diagnostic capabilities develop improved treatment strategies address this challenging Chinese population.

Language: Английский

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Global burden of thyroid cancer in adolescents and young adults (aged 15–39 years) from 1990 to 2021: A systematic analysis of the Global Burden of Disease Study 2021

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0318605 - e0318605

Published: Feb. 14, 2025

Background Thyroid cancer (TC) is the most common malignancy of endocrine system and head-and-neck region, yet data on its burden in adolescents young adults (AYAs) lacking. This study aimed to estimate global TC among AYAs from 1990 2021. Methods Utilizing Global Burden Disease (GBD) 2021 data, we analyzed age-standardized rates incidence, prevalence, disability-adjusted life-years (DALYs) global, regional, national scales. Joinpoint regression was employed determine average annual percentage change (AAPC), with frontier analysis revealing regions for improvement. Decomposition assessed impacts population aging, growth, epidemiological changes. Projections disease extending 2040 were generated using Bayesian Age-Period-Cohort model. Result In 2021, there 48.2 thousand incident cases, 436.1 prevalent 183.5 DALYs worldwide. Meantime, incidence (ASIR), prevalence (ASPR), (ASDR) 1.6, 14.3 6.1 per 100 000, respectively. From ASIR, ASPR ASDR increased AAPCs 1.73, 1.77, 0.38, Socio-demographic resources Saudi Arabia, Taiwan (Province China), Iceland, United Arab Emirates, States Virgin Islands have potential lower due AYAs. Furthermore, 13.3 34.9 new cases occurred males females Among 5 age groups, highest numbers DALYs, along ASRs, observed 35–39 group. projections indicated a continuous rise estimates 60.2 thousand, 558.4 199.7 by 2040, Conclusion The rise, significant disparities regions, genders, highlighting necessity targeted effective interventions.

Language: Английский

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Global trends and disparities in gallbladder and biliary tract cancers: insights from the global burden of disease study 2021

European Journal of Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Background Gallbladder and biliary tract cancers (GBC BTC) are highly malignant, with poor prognoses substantial regional variability in the disease burden. Although advances medical science have improved outcomes high-income regions, low- middle-income regions continue to face rising incidence mortality rates owing delayed detection treatment. Understanding global trends risk factors of GBC BTC is essential for targeted interventions reduce Methods A retrospective analysis was conducted using 2021 Global Burden Disease study. Data from 204 countries territories between 1990 were analyzed incidence, mortality, disability-adjusted life years stratified by age, sex, sociodemographic index (SDI). Trends quantified age-standardized estimated annual percentage changes. Results In 2021, 216,768 new cases 171,961 deaths reported globally, 2.6 2.0 per 100,000, respectively. The Asia-Pacific Latin American exhibited highest burdens. While declined changes incidence: −0.44; mortality: −0.97), low-SDI experienced increases. High BMI emerged as leading factor, contributing 12% years. Projections indicate a stable but 2036. Conclusion decreasing, disparities persist, experiencing increasing Targeted addressing modifiable such obesity, along healthcare infrastructure early detection, critical mitigating this health challenge.

Language: Английский

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