Exploring Disparities in Gill Physiological Responses to NaHCO3-Induced Habitat Stress in Triploid and Diploid Crucian Carp (Carassius auratus): A Comprehensive Investigation Through Multi-Omics and Biochemical Analyses DOI Creative Commons

Shicheng Han,

Lin Han,

Fangying Yuan

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 15(1), P. 5 - 5

Published: Dec. 30, 2024

Background: Owing to the progressive rise in saline waters globally, resulting detrimental impacts on freshwater aquaculture, underlying molecular distinctions governing response alkaline stress between diploid and triploid crucian carp remain unknown. Methods: This investigation explores effects of 20 60 mmol NaHCO3 over 30 days gills carp, employing histological, biochemical, multi-omic analyses. Results: Findings reveal structural damage gill lamellas examined tissue. Diploid exhibit heightened activities superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), phosphatase (AKP), alongside lower malondialdehyde (MDA) urea nitrogen (BUN) levels compared counterparts. Metabolomic investigations suggest alterations purine metabolism, lipid sphingolipid aminoglycan nucleotide sugar metabolism following exposure. Transcriptomic data indicate differential expression genes associated with complement coagulation cascades, IL-17 signaling pathways, Toll-like receptor pathways. Conclusions: Overall, NaHCO3-induced leads significant tissue damage, accompanied by reactive oxygen species (ROS) production causing oxidative disruptions carp. Furthermore, an inflammatory cells triggers immune response. superior antioxidant capacities counterparts, while also displaying reduced responses vivo. Notably, efficiently excrete excess BUN through mitigating protein amino acid imbalances caused accumulation. enables them allocate less energy for coping external environmental stress, redirecting surplus toward growth development. The above results that organisms can better adapt saline–alkaline environments. this study provides novel perspectives into selection different ploidy waters.

Language: Английский

Ecotoxicological effects of per- and polyfluoroalkyl substances in aquatic organisms: A review DOI

Mi-Song Hong,

Jin-Sol Lee, Min‐Chul Lee

et al.

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 214, P. 117678 - 117678

Published: Feb. 20, 2025

Language: Английский

Citations

0
Exploring the neurodegenerative potential of per- and polyfluoroalkyl substances through an adverse outcome pathway network DOI Creative Commons
Sayed Esmaeil Mousavi, Qi Yu, Hyeong‐Moo Shin

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 969, P. 178972 - 178972

Published: Feb. 28, 2025

While emerging evidence links per- and polyfluoroalkyl substances (PFAS) to neurotoxicity, their potential role in neurodegeneration remains poorly understood. Moreover, existing neurodegeneration-related adverse outcome pathways (AOPs) available on AOP-Wiki have not yet been integrated into a unified network. To address these gaps, this study aims develop the first AOP network utilize it explore possible contributions of long-chain legacy PFAS neurodegeneration, specifically concerning Alzheimer's Parkinson's diseases. A total 74 AOPs were screened from AOP-Wiki, which 13 met eligibility criteria incorporated We analyzed resulting using topological parameters such as in-degree, out-degree, eccentricity, betweenness centrality. elucidate mechanistic exposure neurodegenerative pathways, we linking key events (KEs) within The results highlighted increased intracellular calcium hub with highest connectivity followed by critical KEs neuronal apoptosis, oxidative stress, N-methyl-d-aspartate receptor (NMDA-R) overactivation, mitochondrial dysfunction. Consistent toxicological evidence, indicate that may adversely affect neurotransmitter systems, particularly through NMDA-R leading excitotoxicity. This result dyshomeostasis, dysfunction, inflammatory-oxidative cascades, neuroinflammation, cell death. By providing basis for understanding PFAS, offers crucial framework assessing risks associated chemicals inform future regulatory measures public health strategies. Further experimental validation is needed confirm animal models or human populations.

Language: Английский

Citations

0
The Toxicological Effects of Perfluorooctanoic Acid (Pfoa) Exposure in Large Yellow Croaker (Larimichthys Crocea): Linking Liver Damage to Gut Microbiota Dysbiosis DOI

Yadong Xue,

Mingzhe Yuan,

Zhennan Sun

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Exploring Disparities in Gill Physiological Responses to NaHCO3-Induced Habitat Stress in Triploid and Diploid Crucian Carp (Carassius auratus): A Comprehensive Investigation Through Multi-Omics and Biochemical Analyses DOI Creative Commons

Shicheng Han,

Lin Han,

Fangying Yuan

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 15(1), P. 5 - 5

Published: Dec. 30, 2024

Background: Owing to the progressive rise in saline waters globally, resulting detrimental impacts on freshwater aquaculture, underlying molecular distinctions governing response alkaline stress between diploid and triploid crucian carp remain unknown. Methods: This investigation explores effects of 20 60 mmol NaHCO3 over 30 days gills carp, employing histological, biochemical, multi-omic analyses. Results: Findings reveal structural damage gill lamellas examined tissue. Diploid exhibit heightened activities superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), phosphatase (AKP), alongside lower malondialdehyde (MDA) urea nitrogen (BUN) levels compared counterparts. Metabolomic investigations suggest alterations purine metabolism, lipid sphingolipid aminoglycan nucleotide sugar metabolism following exposure. Transcriptomic data indicate differential expression genes associated with complement coagulation cascades, IL-17 signaling pathways, Toll-like receptor pathways. Conclusions: Overall, NaHCO3-induced leads significant tissue damage, accompanied by reactive oxygen species (ROS) production causing oxidative disruptions carp. Furthermore, an inflammatory cells triggers immune response. superior antioxidant capacities counterparts, while also displaying reduced responses vivo. Notably, efficiently excrete excess BUN through mitigating protein amino acid imbalances caused accumulation. enables them allocate less energy for coping external environmental stress, redirecting surplus toward growth development. The above results that organisms can better adapt saline–alkaline environments. this study provides novel perspectives into selection different ploidy waters.

Language: Английский

Citations

0