Bisphenol S accelerates the progression of high fat diet-induced NAFLD by triggering ferroptosis via regulating HMGCS2

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137166 - 137166

Published: Jan. 9, 2025

Language: Английский

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Bisphenol S Induces Lipid Metabolism Disorders in HepG2 and SK-Hep-1 Cells via Oxidative Stress

Toxics, Journal Year: 2025, Volume and Issue: 13(1), P. 44 - 44

Published: Jan. 8, 2025

Bisphenol S (BPS) is a typical endocrine disruptor associated with obesity. To observe BPS effects on lipid metabolism in HepG2 and SK-Hep-1 human HCC cells, CCK-8 assay was used to assess cell proliferation response BPS, the optimal concentration of selected. Biochemical indices such as triglyceride (TG) total cholesterol (T-CHO), oxidative stress malondialdehyde (MDA) catalase (CAT) were measured. ROS MDA levels significantly increased after treatment for 24 h 48 (p < 0.05), indicating an response. Alanine aminotransferase (ALT), T-CHO, low-density lipoprotein (LDL-C) also or treatments 0.05). RT-PCR Western blot analyses detected mRNA protein expression peroxisome proliferator-activated receptor α (PPARα) sterol regulatory element-binding 1c (SREBP1C). The results indicated that could inhibit PPARα carnitine palmitoyl transferase 1B (CPT1B), reduce metabolism, promote SREBP1C fatty acid synthase (FASN), increase synthesis. Increased droplets observed using morphological Oil Red O staining. Our study demonstrates may cause accumulation by increasing perturbing cellular metabolism.

Language: Английский

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Effects of Alexandrium pacificum Exposure on Exopalaemon carinicauda: Hepatopancreas Histology, Antioxidant Enzyme Activity, and Transcriptome Analysis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1605 - 1605

Published: Feb. 13, 2025

Alexandrium pacificum, a dinoflagellate known for causing harmful algal blooms (HABs), has garnered significant attention due to its potential toxicity marine ecosystems, fisheries, and human health. However, the effects of this toxin-producing alga on shrimp are not yet comprehensively understood. This study aimed assess hepatopancreas damage induced by A. pacificum in economically important species E. carinicauda elucidate underlying molecular mechanisms through histology, antioxidant enzyme activity, transcriptome analysis. The were assigned either control group or an exposed group, with latter involving exposure at concentration 1.0 × 104 cells/mL 7 days. A histological analysis subsequently revealed pathological changes tissue including lumen expansion separation basement membrane from epithelial cells, while activity assays demonstrated that weakened defense system, as evidenced reduced activities catalase, superoxide dismutase, glutathione, along increased malondialdehyde levels. Transcriptome further identified 663 significantly upregulated genes 1735 downregulated ones these differentially expressed being primarily associated pathways such protein processing endoplasmic reticulum, mitophagy, glycolysis/gluconeogenesis, sphingolipid metabolism, glycerophospholipid metabolism. provides novel insights into toxicological aquatic organisms enhances current understanding ecotoxicological risks posed HABs.

Language: Английский

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Low lipid levels caused by bisphenol S exposure trigger neuroinflammation and apoptosis in the brain of zebrafish

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 107328 - 107328

Published: March 1, 2025

Language: Английский

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Unraveling the Impact of Micro- and Nano-sized Polymethyl methacrylate on Gut Microbiota and Liver Lipid Metabolism: Insights from Oral Exposure Studies

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126157 - 126157

Published: March 1, 2025

Language: Английский

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