New Psychoactive Substance Esketamine Causes Endocrine-Disrupting Effects and Developmental Toxicity DOI
Siying Li,

Dongdong Ma,

Wenjun Shi

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Esketamine (ESK), a new psychoactive substance known for its strong hallucinogenic effect, has been detected in surface water worldwide. The toxicity of ESK to fish at certain environmental concentration remains unclear. In this study, zebrafish embryos and ZF4 cells were exposed (0, 0.12, 1.02, 10.6 μg L-1, marked by SC, LC, MC, HC, respectively) 14 days post fertilization (dpf) 24 h, respectively. Biphasic dose responses induced observed after h exposure. ESK-LC ESK-MC obviously increased embryo area length, height, volume yolk sac, whereas ESK-HC had the opposite effect. appreciably upregulated transcription expression levels vtg, disrupting cell cycle After dpf exposure, KEGG analysis indicated that circadian rhythm, nucleotide excision repair, estrogen signaling pathways top three impacted pathways, with significantly enhancing gene these except cyp7a1 bh1he41. Correspondingly, notably VTG level, aligning relatively high affinity receptors, as analyzed through molecular docking. Our research demonstrated exhibits developmental endocrine-disrupting effects zebrafish, highlighting need address ecological fish.

Language: Английский

6PPD impairs growth performance by inducing intestinal oxidative stress and ferroptosis in zebrafish DOI
Hao Xu,

Xiaoyu Mao,

Dashuang Mo

et al.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2025, Volume and Issue: 293, P. 110161 - 110161

Published: Feb. 21, 2025

Language: Английский

Citations

0
ADB-FUBINACA-induced developmental toxicity, neurotoxicity, and cardiotoxicity in embryonic zebrafish (Danio rerio) DOI

Yuanzhao Wu,

Fenliang Fan, Lu Zhou

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121517 - 121517

Published: April 1, 2025

Language: Английский

Citations

0
New Psychoactive Substance Esketamine Causes Endocrine-Disrupting Effects and Developmental Toxicity DOI
Siying Li,

Dongdong Ma,

Wenjun Shi

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Esketamine (ESK), a new psychoactive substance known for its strong hallucinogenic effect, has been detected in surface water worldwide. The toxicity of ESK to fish at certain environmental concentration remains unclear. In this study, zebrafish embryos and ZF4 cells were exposed (0, 0.12, 1.02, 10.6 μg L-1, marked by SC, LC, MC, HC, respectively) 14 days post fertilization (dpf) 24 h, respectively. Biphasic dose responses induced observed after h exposure. ESK-LC ESK-MC obviously increased embryo area length, height, volume yolk sac, whereas ESK-HC had the opposite effect. appreciably upregulated transcription expression levels vtg, disrupting cell cycle After dpf exposure, KEGG analysis indicated that circadian rhythm, nucleotide excision repair, estrogen signaling pathways top three impacted pathways, with significantly enhancing gene these except cyp7a1 bh1he41. Correspondingly, notably VTG level, aligning relatively high affinity receptors, as analyzed through molecular docking. Our research demonstrated exhibits developmental endocrine-disrupting effects zebrafish, highlighting need address ecological fish.

Language: Английский

Citations

0