Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Journal Year: 2024, Volume and Issue: unknown, P. 159589 - 159589
Published: Dec. 1, 2024
Language: Английский
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Journal Year: 2024, Volume and Issue: unknown, P. 159589 - 159589
Published: Dec. 1, 2024
Language: Английский
Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105202 - 105202
Published: April 1, 2025
Language: Английский
Citations
0Tissue and Cell, Journal Year: 2025, Volume and Issue: 95, P. 102937 - 102937
Published: April 27, 2025
Language: Английский
Citations
0Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 129, P. 106862 - 106862
Published: April 28, 2025
Language: Английский
Citations
0International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137484 - 137484
Published: Nov. 9, 2024
Language: Английский
Citations
1Research, Journal Year: 2024, Volume and Issue: 7
Published: Jan. 1, 2024
Atrazine (AT), a widely utilized chemical herbicide, causes widespread contamination of agricultural water bodies. Recently, exposure to AT has been linked the development age-related neurodegenerative diseases (NDs), suggesting its neurotoxicity potential. As an endocrine disruptor, targets hypothalamus, crucial part neuroendocrine system. However, toxicological mechanism hypothalamus and correlation with ND remain unexplored. Our results indicated that caused significant morphological structural damage leading loss mature intact neurons microglial activation. Furthermore, hypothalamic neural stem cells (HtNSCs) were recruited areas neuronal by AT. Through in vivo vitro experiments, we clarified outcomes AT-induced HtNSC recruitment alongside mature/intact neurons. Mechanistically, induces senescence these HtNSCs activating integrated stress response signaling. This consequently hinders repair damaged inhibiting proliferation differentiation. Overall, our findings underscore pivotal role pathway damage. Additionally, present study offers novel perspectives understand mechanisms provides preliminary evidence linking NDs.
Language: Английский
Citations
1Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127555 - 127555
Published: Oct. 18, 2024
Language: Английский
Citations
0Tissue and Cell, Journal Year: 2024, Volume and Issue: 93, P. 102646 - 102646
Published: Nov. 30, 2024
Language: Английский
Citations
0Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Journal Year: 2024, Volume and Issue: unknown, P. 159589 - 159589
Published: Dec. 1, 2024
Language: Английский
Citations
0