Cited by 6-PPD quinone causes lipid accumulation across multiple generations differentially affected by metabolic sensors and components of COMPASS complex in Caenorhabditis elegans

Aged Biodegradable Nanoplastics Enhance Body Accumulation Associated with Worse Neuronal Damage in Caenorhabditis elegans DOI

Tianshu Wu, Jing He,

Zongjian Ye

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

The environmental and health challenges posed by petroleum-based biodegradable plastics, such as polybutylene succinate (PBS) polybutyleneadipate-co-terephthalate (PBAT), are a significant concern because they increasingly present in the environment contribute substantial proportion of microplastics (MPs) or nanoplastics (NPs). In this study, ultraviolet (UV)-aged PBS-NPs PBAT-NPs found to have higher propensity accumulate within body Caenorhabditis elegans (C. elegans) prolonging defecation interval, which could induce severe neuronal damage compared pristine NPs. increased accumulation (BNPs) subsequent impairments neurobehavior highly attributed their reduced particle size altered surface properties, including changed chemical bonds functional groups after photoaging. Aged BNPs also cause more GABAergic neurons neurotransmitter receptors, resulting disrupted homeostasis behaviors. Overall, both PBS PBAT components show no differences biological mechanisms neural damage, highlighting commonalities characteristics adverse effects on nervous system. Our study opens up exploration impacts photoaging degradation state that environment.

Language: Английский

Citations

6-PPD quinone causes alteration in ubiquinone-mediated complex III associated with toxicity on mitochondrial function and longevity in Caenorhabditis elegans DOI

Xin Hua, Dayong Wang

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 116571 - 116571

Published: April 1, 2025

Language: Английский

Citations

Paeoniflorin alleviates toxicity and accumulation of 6-PPD quinone by activating ACS-22 in Caenorhabditis elegans DOI