Super-Resolution Mitochondrial Fluorescent Probe for Accurate Monitoring of Drug-Induced Liver Injury

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Drug-induced liver injury (DILI) has emerged as an urgent clinical challenge. It is characterized by mitochondrial dysfunction in cells, which leads to abnormal changes H2O2 levels within the mitochondria. Super-resolution imaging allows for observation of fine structure mitochondria at nanometer scale, potentially enabling detection during DILI subcellular organelle level. Here, we report design and synthesis a novel H2O2-activated probe levels. SML near-infrared (NIR) fluorescent with large Stokes shift (260 nm) sensing mechanism based on intramolecular charge transfer (ICT) switching. was conducted using structured illumination microscopy (SIM). The improved accuracy observing periods be effectively utilized rapid monitoring nanoscale upregulation hepatic fibrosis, thus providing capability screen effective therapeutic candidates.

Language: Английский

MRI-Responsive Nanoprobes for Visualizing Hydrogen Peroxide in Diabetic Liver Injury

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123292 - 123292

Published: March 1, 2025

Language: Английский

A potent fluorescent probe for HOCl with dual NIR emissions: achieving the early diagnosis of polystyrene microplastics-induced liver injury involved in ferroptosis

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138087 - 138087

Published: March 1, 2025

Language: Английский