Prediction of Nitrate Concentration and the Impact of Land Use Types on Groundwater in the Nansi Lake Basin

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137185 - 137185

Published: Jan. 14, 2025

Language: Английский

Acute and Subacute Oral Exposure to Inorganic Arsenic Significantly Impacted the Pathology of a Mouse Model With Th2‐ and Th17‐, But Not Th1‐Dependent Allergy Development

Journal of Applied Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

ABSTRACT Increased blood levels of inorganic arsenic compounds (iAs) are associated with the onset allergic diseases. This study investigated direct relationship between oral exposure to iAs and several A mouse model type 1, 2, 17 helper T cell (Th1, Th2, Th17) dependent allergies was generated in female BALB/c mice by topical treatment 2,4‐dinitrochlorobenzene, toluene‐2,4‐diisocyanate, imiquimod. Several concentrations (0, 0.3, 3, 10 mg/kg) were administered orally for 3 or 4 days during each allergen challenge. Itch behavior changes skin thickness monitored, animals euthanized, inflammatory responses auricular lymph nodes analyzed. The influence subacute (0.3 24–52 days) on development chronic Th2 allergy examined using models TDI‐induced atopic dermatitis Dermatophagoides farinae ‐induced asthma. Acute significantly exacerbated Th2‐ Th17‐dependent allergies, whereas Th1‐dependent reactions not influenced. corroborated low a allergy. Symptoms immune increased following exposure. Our findings imply that affects pathology development, but

Language: Английский

Hydrogeochemical characteristics, source distribution, and health risk of high-fluoride groundwater in Swabi, Pakistan

Environmental Monitoring and Assessment, Journal Year: 2024, Volume and Issue: 197(1)

Published: Dec. 6, 2024

Language: Английский