THE EFFECT OF NANOPLASTICS AND MICROPLASTICS ON LUNG MORPHOLOGY AND PHYSIOLOGY: A SYSTEMATIC REVIEW DOI Creative Commons

Y.V. Rybalchenko

The Medical and Ecological Problems, Journal Year: 2024, Volume and Issue: 28(3), P. 42 - 60

Published: Dec. 30, 2024

Airborne microplastic (NP) and nanoplastic (MP) pollution has emerged as a pressing environmental concern with significant implications for human health. While MPs are present both indoors outdoors, indoor concentrations generally higher due to the abrasion of household materials, furniture, other domestic sources. NPs, when inhaled, accumulate in various lung regions, exerting toxic effects potentially leading respiratory diseases. This systematic review, conducted according PRISMA guidelines, evaluates recent experimental studies on pathogenic impact nanomicroplastics (NMPs) tissues using vivo vitro models. The review included 10 analyzing MP accumulation 90 examining pathogenetic mechanisms exposure. Research data indicates predominance polymeric fibers such polypropylene, polyethylene terephthalate, polytetrafluoroethylene, accounting nearly half structures. NMPs exhibit size- composition-dependent accumulation, smaller positively charged particles showing translocation potential systemic circulation organs. highlights synergistic heavy metals pollutants, interaction pulmonary surfactant, role exacerbating Current analysis underscores growing interest NMP-related health risks identifies knowledge gaps, including need standardization NMP toxicity testing further exploration biological systems. findings emphasize importance mitigating exposure safeguard pave way future research long-term impacts airborne

Language: Английский

Duck House Inhalable Particulate Matter Induces Lung Injury by Activating Ferroptosis DOI Creative Commons
Zhiyun Guo, Tongjie Chai, Liang Yu

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105169 - 105169

Published: April 1, 2025

Language: Английский

Citations

0
A potent fluorescent probe for HOCl with dual NIR emissions: achieving the early diagnosis of polystyrene microplastics-induced liver injury involved in ferroptosis DOI
Jianwei Cui,

James T. C. Teng,

Peini Xiang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138087 - 138087

Published: March 1, 2025

Language: Английский

Citations

0
Risk factors for Drug-Related Non-Infectious pneumonia: insights from the FDA adverse event reporting system (FAERS) DOI

Peize Meng,

Yi Zhang, Qingnan Zhao

et al.

Expert Opinion on Drug Safety, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Non-infectious pneumonitis (NIP) is a severe adverse drug reaction. To better understand drug-induced NIP, improve patient safety, and inform clinical decision-making, this study aims to utilize the FDA Adverse Event Reporting System (FAERS) database evaluate association between medications identify potential risk factors, offer alerts. We reviewed FAERS from 2004 through second quarter of 2024. Using 'NIP' as search term, we sorted, counted, analyzed cases by generic name trends reports related NIP submitted database. employed four statistical methods drugs associated with NIP. From 21,433,114 reported events (AEs), 9,224 were classified Our analysis identified 20 main categories being antineoplastic agents, antibiotics immunosuppressants. Daptomycin, methotrexate, tacrolimus had highest NIP-related deaths. Trends in AEs reporting indicate that showing fastest increase are daptomycin, sertraline, amiodarone. These findings could assist clinicians early identification drug-related provide valuable insights for future research into mechanisms underlying

Language: Английский

Citations

0
THE EFFECT OF NANOPLASTICS AND MICROPLASTICS ON LUNG MORPHOLOGY AND PHYSIOLOGY: A SYSTEMATIC REVIEW DOI Creative Commons

Y.V. Rybalchenko

The Medical and Ecological Problems, Journal Year: 2024, Volume and Issue: 28(3), P. 42 - 60

Published: Dec. 30, 2024

Airborne microplastic (NP) and nanoplastic (MP) pollution has emerged as a pressing environmental concern with significant implications for human health. While MPs are present both indoors outdoors, indoor concentrations generally higher due to the abrasion of household materials, furniture, other domestic sources. NPs, when inhaled, accumulate in various lung regions, exerting toxic effects potentially leading respiratory diseases. This systematic review, conducted according PRISMA guidelines, evaluates recent experimental studies on pathogenic impact nanomicroplastics (NMPs) tissues using vivo vitro models. The review included 10 analyzing MP accumulation 90 examining pathogenetic mechanisms exposure. Research data indicates predominance polymeric fibers such polypropylene, polyethylene terephthalate, polytetrafluoroethylene, accounting nearly half structures. NMPs exhibit size- composition-dependent accumulation, smaller positively charged particles showing translocation potential systemic circulation organs. highlights synergistic heavy metals pollutants, interaction pulmonary surfactant, role exacerbating Current analysis underscores growing interest NMP-related health risks identifies knowledge gaps, including need standardization NMP toxicity testing further exploration biological systems. findings emphasize importance mitigating exposure safeguard pave way future research long-term impacts airborne

Language: Английский

Citations

0