Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117678 - 117678

Published: Jan. 1, 2025

PANoptosis is a newly discovered complex programmed cell death (PCD) form. In the field of cancer research, involved in multiple pathways that affect tumor survival, proliferation, and response to treatment, serving as an innovative strategy for therapy. Endocrine-disrupting chemicals (EDCs) impact endocrine system, including cancer. However, research on their influence head neck carcinoma (HNSC) through genes remains limited. This study utilises transcriptomic clinical data related HNSC from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. We developed risk model based PANoptosis-related LASSO Cox regression analysis. Finally, we utilized Sankey diagram depict relationships between EDCs key genes, identifying DSCAM, IL-6, SYCP2 critical predictors PANoptosis. These essential identified 214 potentially influencing HNSC, 3 (Aroclor 1242, Pentachlorobenzene, Propanil) previously unreported HNSC. findings elucidate novel mediated by pathogenesis

Language: Английский

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Fenoxycarb induces cardiovascular, hepatic, and pancreatic toxicity in zebrafish larvae via ROS production, excessive inflammation, and apoptosis

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 969, P. 178957 - 178957

Published: Feb. 26, 2025

Language: Английский

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Magnolol protects C6 glioma cells against neurotoxicity of FB1 via modulating PI3K/Akt and mitochondria-associated apoptosis signaling pathways

Environmental Pollution, Journal Year: 2025, Volume and Issue: 372, P. 126017 - 126017

Published: March 6, 2025

Language: Английский

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Environmental and toxicological effects of carbamate pesticides on zebrafish embryogenesis

Molecular & Cellular Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

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