Lung-associated lymph nodes and spleen are major secondary accumulating organs in mice following inhaled black carbon as a surrogate of ultrafine ambient particles DOI Creative Commons
Gyuri Kim, Soyeon Jeon, Bum Jun Park

et al.

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109475 - 109475

Published: April 1, 2025

Despite increasing public concern about the health impact of air pollution, little is known biokinetics ultrafine particles. Herein, we investigate their and associated mechanisms underlying organ distribution extrapulmonary translocation ambient particulate matter in mice. The test materials used this study were black carbon (BC) generated by a spark discharge soot generator two reference (SRM 2975 black). particles intratracheally instilled into lungs mice at 25 μg/mouse, burden was evaluated up to 3 months post-instillation. data showed significant BC accumulation lung-associated lymph nodes (LALN) spleen from 1-3 post-exposure, with no detectable levels other organs. similar pattern, indicating common pathway for deposited alveoli. This unique alveoli, as direct injection lymphatic systemic circulation typical (e.g., liver, lung, spleen, LALN). results highlight that LALN may be due escape lung being smallest particles, evading hepatic surveillance but physically entrapped spleen's open circulation.

Language: Английский

Lung-associated lymph nodes and spleen are major secondary accumulating organs in mice following inhaled black carbon as a surrogate of ultrafine ambient particles DOI Creative Commons
Gyuri Kim, Soyeon Jeon, Bum Jun Park

et al.

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109475 - 109475

Published: April 1, 2025

Despite increasing public concern about the health impact of air pollution, little is known biokinetics ultrafine particles. Herein, we investigate their and associated mechanisms underlying organ distribution extrapulmonary translocation ambient particulate matter in mice. The test materials used this study were black carbon (BC) generated by a spark discharge soot generator two reference (SRM 2975 black). particles intratracheally instilled into lungs mice at 25 μg/mouse, burden was evaluated up to 3 months post-instillation. data showed significant BC accumulation lung-associated lymph nodes (LALN) spleen from 1-3 post-exposure, with no detectable levels other organs. similar pattern, indicating common pathway for deposited alveoli. This unique alveoli, as direct injection lymphatic systemic circulation typical (e.g., liver, lung, spleen, LALN). results highlight that LALN may be due escape lung being smallest particles, evading hepatic surveillance but physically entrapped spleen's open circulation.

Language: Английский

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