Acute and Subacute Oral Exposure to Inorganic Arsenic Significantly Impacted the Pathology of a Mouse Model With Th2‐ and Th17‐, But Not Th1‐Dependent Allergy Development DOI

Reo Matsuzaka,

Yousuke Ogata,

Narumi Kato

et al.

Journal of Applied Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

ABSTRACT Increased blood levels of inorganic arsenic compounds (iAs) are associated with the onset allergic diseases. This study investigated direct relationship between oral exposure to iAs and several A mouse model type 1, 2, 17 helper T cell (Th1, Th2, Th17) dependent allergies was generated in female BALB/c mice by topical treatment 2,4‐dinitrochlorobenzene, toluene‐2,4‐diisocyanate, imiquimod. Several concentrations (0, 0.3, 3, 10 mg/kg) were administered orally for 3 or 4 days during each allergen challenge. Itch behavior changes skin thickness monitored, animals euthanized, inflammatory responses auricular lymph nodes analyzed. The influence subacute (0.3 24–52 days) on development chronic Th2 allergy examined using models TDI‐induced atopic dermatitis Dermatophagoides farinae ‐induced asthma. Acute significantly exacerbated Th2‐ Th17‐dependent allergies, whereas Th1‐dependent reactions not influenced. corroborated low a allergy. Symptoms immune increased following exposure. Our findings imply that affects pathology development, but

Language: Английский

Coexposure to fluoride and sulfur dioxide aggravates enamel mineralization disorders in mice by disrupting calcium homeostasis-mediated endoplasmic reticulum stress DOI
Wentai Wang, Na Yang,

Junlin Yang

et al.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115317 - 115317

Published: Feb. 1, 2025

Language: Английский

Citations

0
Geogenic Contamination of Groundwater in a Highland Watershed: Hydrogeochemical Assessment, Source Apportionment, and Health Risk Evaluation of Fluoride and Nitrate DOI Creative Commons
Khan Alam, Mohammad Nafees, Wajid Ali

et al.

Hydrology, Journal Year: 2025, Volume and Issue: 12(4), P. 70 - 70

Published: March 26, 2025

Groundwater is one of the major sources freshwater supply for drinking and domestic purposes. This study evaluates hydrogeochemical processes, groundwater quality human consumption, associated health risks from fluoride F− nitrate (NO3−), dissolved solutes in a highland watershed northern Pakistan. samples (n = 51) were gathered analyzed range physicochemical parameters. To evaluate contamination, indices such as pollution index (NPI) (FPI) applied, along with composite to assess overall water quality. The findings revealed that total solid, turbidity, F−, K+ levels exceeded health-based thresholds 20%, 1%, 4%, 2% samples, respectively. Among sources, handpumps identified most contaminated. According NPI index, 96% 92% did not show significant However, FPI results highlighted 59% exhibited low pollution, while 41% fell under medium levels. While NO3− ingestion posed no notable risks, exposure presented concerns, 58.8% posing particularly children. dominant hydrochemical facies Ca-Mg-HCO3, main influence on chemistry by rock-water interactions reverse ion exchange processes.

Language: Английский

Citations

0
Acute and Subacute Oral Exposure to Inorganic Arsenic Significantly Impacted the Pathology of a Mouse Model With Th2‐ and Th17‐, But Not Th1‐Dependent Allergy Development DOI

Reo Matsuzaka,

Yousuke Ogata,

Narumi Kato

et al.

Journal of Applied Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

ABSTRACT Increased blood levels of inorganic arsenic compounds (iAs) are associated with the onset allergic diseases. This study investigated direct relationship between oral exposure to iAs and several A mouse model type 1, 2, 17 helper T cell (Th1, Th2, Th17) dependent allergies was generated in female BALB/c mice by topical treatment 2,4‐dinitrochlorobenzene, toluene‐2,4‐diisocyanate, imiquimod. Several concentrations (0, 0.3, 3, 10 mg/kg) were administered orally for 3 or 4 days during each allergen challenge. Itch behavior changes skin thickness monitored, animals euthanized, inflammatory responses auricular lymph nodes analyzed. The influence subacute (0.3 24–52 days) on development chronic Th2 allergy examined using models TDI‐induced atopic dermatitis Dermatophagoides farinae ‐induced asthma. Acute significantly exacerbated Th2‐ Th17‐dependent allergies, whereas Th1‐dependent reactions not influenced. corroborated low a allergy. Symptoms immune increased following exposure. Our findings imply that affects pathology development, but

Language: Английский

Citations

0